Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission

Maia, Wcleubianne Matias Nascimento; Andrade, Francisco das Chagas Pereira de; Filgueiras, Lívia Alves; Mendes, Anderson Nogueira; Assunção, Amanda Fonseca Costa; Rodrigues, Nícolas Davidson Sérvulo; Marques, Rosemarie Brandim; Filho, Antônio Luíz Martins Maia; Sousa, Damião Pergentino de; Lopes, Lawrence Gonzaga

doi:10.1016/j.heliyon.2021.e06620

Cited by 15 publications

(6 citation statements)

References 63 publications

(40 reference statements)

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“…However, damask rose could not reduce TAIS. This finding was in line with a previous meta-analysis that pooled the studies about damask rose mill on anxiety, indicating that damask rose dramatically decreased state anxiety but had no obvious effect on trait anxiety ( 73 ). Damask rose mainly contains isoflavones.…”

Section: Discussionsupporting

confidence: 92%

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Tan

Liao

Long

et al. 2023

Front. Public Health

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Background and purposeThe findings of clinical studies exploring essential oils (EOs) for anxiety remain disputed, and no studies have yet clarified the differences in the efficacy of EOs. The purpose of the study was to directly or indirectly compare the efficacy of different types of EOs on anxiety by pooling the results of randomized controlled trials (RCTs).MethodsPubMed, Cochrane Library, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched from inception to November 2022. Only full texts of RCTs that investigated the effects of EOs on anxiety were included. The trial data were extracted and the risk of bias was assessed by two reviewers independently. Pairwise meta-analysis and network meta-analysis were performed by Stata 15.1 or R 4.1.2 software.ResultsForty-four RCTs (fifty study arms) involving 10 kinds of EOs and 3419 anxiety patients (1815 patients in EOs group and 1604 patients in control group) were included. Pairwise meta-analyses showed that EOs were effective in reducing State Anxiety Inventory scores (SAIS) [WMD = −6.63, 95% CI−8.17, −5.08] and Trait Anxiety Inventory scores (TAIS) [WMD = −4.97, 95% CI−6.73, −3.20]. Additionally, EOs could decrease systolic blood pressure (SBP) [WMD = −6.83, (95% CI −10.53, −3.12), P < 0.001] and heart rate (HR) [WMD = −3.43, (95% CI −5.51, −1.36), P < 0.001]. Network meta-analyses demonstrated that regarding the outcome of SAIS, Jasminum sambac (L.)Ait. (jasmine) was the most effective with a weighted mean difference (WMD) of−13.61 (95% CrI−24.79, −2.48). Followed by Citrus (citrus aurantium L.), which had a WMD of−9.62 (95% CrI−13.32, −5.93). Moderate effect sizes were observed for Rosa rugosa Thunb. (damask rose) (WMD = −6.78, 95% CrI−10.14, −3.49) and Lavandula angustifolia Mill. (lavender) (WMD = −5.41, 95% CrI−7.86, −2.98). Regarding the results of TAIS, citrus aurantium L. was the best ranked intervention with a WMD of−9.62 (95% CrI−15.62, −3.7). Moderate-to-large effect sizes were observed for Citrus limon (L.) Burm. F. (lemon) (WMD:−8.48; 95% CrI−16.67, −0.33) and lavender (WMD:−5.5; 95% CrI−8.7, −2.46).ConclusionAccording to the comprehensive analysis, EOs are effective in reducing both state anxiety and trait anxiety, and citrus aurantium L. essential oil seems to be the most recommended type of EO for treating anxiety because of its significant effects in reducing SAIS and TAIS.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022331319.

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Section: Discussionsupporting

confidence: 92%

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Tan

Liao

Long

et al. 2023

Front. Public Health

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“…However, damask rose could not reduce TAIS. This finding was in line with a previous metaanalysis that pooled the studies about damask rose mill on anxiety, indicating that damask rose dramatically decreased state anxiety but had no obvious effect on trait anxiety (73). Damask rose mainly contains isoflavones.…”

Section: Possible Explanation For Study Findingssupporting

confidence: 91%

“…However, we chose self-administrated paper surveys and collected the questionnaires on the spot, which reduced this problem. In addition to including the reporting data from parents and teachers, future research could consider using methodological approaches, such as multidimensional item response theory and responder misclassification correction formulas (72,73), to analyze the self-reported outcome bias.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Cities and mental health

2023

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…Following the structural similarity, Andrade et al (2021) studied the effects of hydroxycitronellal on anxiolytic activity, reaching a similar result when comparing the motor effect of this substance. As observed in other studies, monoterpenes in general do not have a negative effect on the locomotor system even if they have anxiolytic effects, this is important for the formulation and discovery of new compounds, since their use is considered acceptable in terms of their motor activity and carrying out daily tasks (Souto-Maior et al, 2017;Matias Nascimento Maia et al, 2021).…”

Section: Discussionmentioning

confidence: 58%

Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers

et al. 2023

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Due to the complex nature of pain and the participation of physical, cognitive, psychological and behavioral aspects, pain management has several approaches. The use of medicinal plants in developing countries is quite expressive. Seeking new options for the treatment of emerging or debilitating diseases. Therefore, the present study seeks to elucidate the effects of the monoterpene, citronellal, differentiating its activity by isomers (R)-(+) and (S)-(-) citronellal. The study used several methods to evaluate the effects of citronellal isomers on motor coordination, nociceptive response, and the involvement of opioid, glutamatergic, and transient receptor pathways. The methods included rota-rod, hot-plate, and formalin tests, as well as the use of specific inhibitors and agonists. Data were analyzed using inferential statistics with a 95% confidence level. Both isomers did not significantly affect the motor coordination of the studied animals. The isomer (S)-(-) citronellal showed better results in relation to its structural counterpart, managing to have an antinociceptive effect in the formalin and hot plate tests with a lower concentration (100 mg/kg) and presenting fewer side effects, however, the this study was not able to elucidate the mechanism of action of this isomer despite having activity in studies with substances that act on specific targets such as glutamate and capsaicin, its activity was not reversed with the use of antagonists for pathways related to nociception. While the (R)-(+) citronellal isomer, despite showing total activity only at a concentration of 150 mg/kg, was able to determine its mechanism of action related to the opioid pathway by reversing its activity by the antagonist naloxone, being this is a pathway already correlated with nociception control treatments, however, it is also related to some unwanted side effects. In this way, new studies are sought to elucidate the mechanism related to the isomer (S)-(-) citronellal and a possibility of use in other areas related to the treatment of pain or inflammation.

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Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission

Cited by 15 publications

References 63 publications

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Cities and mental health

Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers

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