Antidepressant activity of Citrus limetta leaves in mice using battery of behavior models modulating via serotonergic systems

Kaur, Jaspreet; Bhatia, Manisha; Nain, Parminder

doi:10.3329/bjp.v14i4.42499

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…These outcomes specify that the antidepressant activity of AEAES involves the 5HT 2 serotonergic receptors interaction but not 5HT 1 and 5HT 3 receptor interactions. Few studies reported the interaction of either an extract or flavonoids with serotonergic receptors in producing an antidepressant-like effect on the monoaminergic system, indicating a comparable mode of action of these compounds 6,17,21,22 .…”

Section: Fig 3: Effect Of Aeaes Pretreated With Opioid Receptor Block...mentioning

confidence: 99%

Untitled

2022

IJPSR

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Background: Depression is a state of mental illness characterized by long-lasting moods of desolation. Typical to atypical antidepressants are available in modern medicine for depression therapy, but the side effects are still questionable. Aqueous extract of Abelmoschus esculentus seeds (AEAES) from the Okra has been chosen for the study. AEAES has already been shown to exhibit an antidepressant-like effect, but there is no information about its mechanism. The current study has studied the monoaminergic and opioid systems' involvement in the antidepressant effect of AEAES. Methods:The current study has shown the signal for the role of nor-adrenergic and serotonergic systems in the antidepressant activity of AEAES in mice using the Forced swim test (FST). Swiss Albino female mice were treated with vehicle AEAES (200 mg/kg) orally, and different types of receptor antagonists were used to demonstrate the mechanism of action of an AEAES. Results: The antidepressant action exhibited by AEAES was obliterated by the pre-treatment of mice with p-chlorophenylalanine (100 mg/kg, i.p., serotonin synthesis inhibitor), Ketanserin (5 mg/kg, i.p., a 5HT 2A/2B antagonist) and Prazosin (1 mg/kg, i.p., an α 1 blocker) but the effect was not abolished with Pindolol (10 mg/kg, i.p., 5HT 1A/1B antagonist), Ondansetron (1 mg/kg, i.p., 5HT 3 antagonist), Yohimbine (1 mg/kg, i.p., an α 2 blocker) and Naloxone (1 mg/kg, i.p., an opioid antagonist). Conclusions: The current study delivers evidence that the antidepressant activity of AEAES in FST is mediated through the interaction with the serotonergic receptor (5-HT 2A/2B ) and noradrenergic receptor (α-1 adrenoceptor) without influencing the opioid receptors.INTRODUCTION: Depression, the most common affective or mood disorder along with mania, is considered a devastating disorder with disturbing mood.

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Section: Fig 3: Effect Of Aeaes Pretreated With Opioid Receptor Block...mentioning

confidence: 99%

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2022

IJPSR

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“…Further pharmacological and biological activities were recently discovered such as anticoagulant and antithrombotic effects (Siritapetawee et al, 2020) and the antiviral activity against the virus of tomato yellow leaf curl (Zhao et al, 2021). Several medicinal plants as Agaricus blazei (Haq et al, 2019), Capsicum annuum (Jawad et al, 2017), Citrus limetta (Kaur et al, 2019), Glycyrrhiza glabra (Dhingra and Sharma, 2006), Hypericum perforatum (Tian et al, 2014), Mondia whitei (Oketch-Rabah, 2012), Salvia officinalis (El Gabbas et al, 2018) were reported to possess antidepressant-like effect. There is a need to find new antidepressant biomolecules to respond to the increase in the incidence of anxiety as a modern disease and oxidative stress as a major source of different diseases.…”

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confidence: 99%

Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera

Badaoui

Moubtakir

Terrafe

et al. 2022

Bangladesh J Pharmacol

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This study aims to examine the antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera in mice. Antianxiety and sedative effects were examined using the elevated plus maze test, open field test, and thiopental-induced sleeping time respectively. While the antidepressant effect was evaluated, using the forced swimming test. E. resinifera reduced the latency of sleeping and increased sleeping time significantly at 75 mg/kg. It reduced the immobility time and increased swimming significantly at all doses assessed (25, 50, and 75 mg/kg). Pretreatment with antagonists reversed these effects indicating the possible involvement of α2, 5HT2, D2, and GABAA receptors respectively. These findings confirm the traditional utilization of this plant as an antioxidant, anxiolytic, and antidepressant.

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“…[10] Many cosmetic companies use Citrus limetta as a key ingredient in their products as it has antioxidant, antibacterial, and detoxifying properties which are useful against hyperpigmentation and tanning. [11] Citrus limetta leaves extract was also reported to be effective as an antidepressant [12] and antihypertensive. [13] The citric acid in leaves extract of citrus limetta acted as a reducing and capping agent in the green synthesis of TiO 2 nanoparticles.…”

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confidence: 99%

Neodymium oxide nanoparticles synthesis using phytochemicals of leaf extracts of different plants as reducing and capping agents: Growth mechanism, optical, structural and catalytic properties

Ahmed

Rizvi

Shahzad

et al. 2022

J Chinese Chemical Soc

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The main idea of this research is to synthesize the neodymium oxide (Nd2O3) nanoparticles with a particle size of less than 10 nm and to investigate the influence of leaf extracts of different plants. Leaf extracts of three plants namely Phyllanthus emblica, Citrus limetta, and Citrus paradisi, were used for the fabrication of Nd2O3 via the sol–gel and green synthesis methods, and the mechanism for the synthesis of neodymium oxide has been investigated. All prepared samples were subjected to UV–Visible Spectroscopy, Fourier Transform Infrared spectroscopy (FTIR), Thermogravimetric analysis (TGA), X‐ray diffraction (XRD) analysis, and Scanning Electron Microscopy (SEM) and Energy Dispersive X‐ray (EDX) analysis to study the optical and structural properties. The band gap of the neodymium oxide nanoparticles was observed between 4.45 and 5.26 eV. The bond length of Nd‐O for the neodymium oxide samples as‐synthesized was calculated as 2.18 and 2.24 Å by using FTIR data. Furthermore, kinetic and thermodynamic parameters were calculated using TGA. XRD patterns showed the formation of cubic, monoclinic, and hexagonal structures of Nd2O3. The Nd2O3 nanoparticles were used as photocatalysts for the degradation of methylene blue under irradiation of sunlight, and the maximum percentage degradation of 74.8% was observed.

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Antidepressant activity of Citrus limetta leaves in mice using battery of behavior models modulating via serotonergic systems

Cited by 5 publications

References 14 publications

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Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera

Neodymium oxide nanoparticles synthesis using phytochemicals of leaf extracts of different plants as reducing and capping agents: Growth mechanism, optical, structural and catalytic properties

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