Antidepressant activity of Asparagus racemosus in rodent models

Singh, Gireesh Kumar; Garabadu, Debapriya; Muruganandam, A. V.; Joshi, Vinod Kumar; Krishnamurthy, Sairam

doi:10.1016/j.pbb.2008.07.010

Cited by 88 publications

(46 citation statements)

References 49 publications

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“…Several herbal medicines (e.g., Panax notoginseng [3], Asparagus racemosus [4], Rosmarinus officinalis [5], and St. John’s wort [6]) have been reported to have antidepressant activity comparable with prescription medicines but with fewer side effects.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats

Matsuzaki

Sasaki

Iwata

et al. 2013

BMC Complement Altern Med

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BackgroundGanoderma lucidum is a popular medicinal mushroom used for promoting health and longevity in Asian countries. Previously, we reported that a water-soluble extract from a culture medium of Ganoderma lucidum mycelia (MAK) exerts antioxidative and cerebroprotective effects against ischemia–reperfusion injury in vivo. Here, we evaluated the antidepressant and anxiolytic activities of MAK in rats.MethodsMAK (0.3 or 1 g/kg, p.o.) was administered in the experimental animals 60 min before the forced swimming, open-field, elevated plus-maze, contextual fear-conditioning, and head twitch tests. Additionally, the mechanisms involved in the antidepressant-like action of MAK were investigated by the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP)- or 5-HT2A agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch responses.ResultsTreatment with MAK (1 g/kg) exhibited antidepressant-like effects in the forced swimming test, attenuated freezing behavior in the contextual fear-conditioning test, and decreased the number of head twitches induced by DOI, but not with 5-HTP. No significant response was observed in locomotion or anxiety-like behavior, when the animals were evaluated in the open-field or elevated plus-maze test, respectively.ConclusionsThese data suggest that MAK has antidepressant-like potential, which is most likely due to the antagonism of 5-HT2A receptors, and possesses anxiolytic-like effects toward memory-dependent and/or stress-induced anxiety in rats.

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Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats

Matsuzaki

Sasaki

Iwata

et al. 2013

BMC Complement Altern Med

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“…4 Aqueous extract of whole plant of AR standardized to Shatavarin IV and immunoside showed immunomodulatory activity in animals. 5 Saponins are considered to be the major active constituents and methanolic extract of root of AR (MAR) standardized to saponins showed anti-depressant, 6 nootropic and anti-amnesic activities 7 in animal models. Moreover, it has been reported that the MAR possesses the highest amount of saponins and exhibits maximum inhibitory effect on acetylcholine and monoamine metabolizing enzymes in vitro.…”

Section: Introductionmentioning

confidence: 99%

Asparagus racemosusmodulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats

Krishnamurthy

Garabadu

Reddy

2013

Nutritional Neuroscience

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“…Therefore, it is urgent to explore more promising antidepressants for clinical needs of depressed patients. Nowadays, the use of traditional herbs such as traditional Chinese medicine, traditional Ayurvedic medicine and other folk medicines has provided us a prospective alternative in the treatment of depression (Singh et al, 2009;Yi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina

Lan

Liu

Wang

et al. 2012

Journal of Ethnopharmacology

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Antidepressant activity of Asparagus racemosus in rodent models

Cited by 88 publications

References 49 publications

Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats

Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats

Asparagus racemosusmodulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats

Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina

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