Antidepressant activity of aqueous extracts of Curcuma longa in mice

Yu, Zhonghan; Kong, Ling-Dong; Chen, Y

doi:10.1016/s0378-8741(02)00211-8

Cited by 212 publications

(109 citation statements)

References 18 publications

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“…Antidepressants properties of turmeric are mediated through inhibition of monoamine oxidize A. [76] Ethanolic extract of C. longa causes to reverse the decrease in serotonin, noradrenaline, and dopamine concentrations as well as the increase in serotonin turnover, cortisol levels, and serum corticotrophin-releasing factor. [77] Xu et al [78] examined the consequence of orally directed curcumin on behavior in a long-lasting stress model of depression in rats.…”

Section: Antidepressant Properties and Effect On Nervous Systemmentioning

confidence: 99%

Untitled

Ashraf¹

2017

IJGP

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Curcuma longa Linn. is well-known and valued medicinal plant. It has a long history of traditional uses ranging from folk medicine to several culinary preparations. The phytochemical, pharmacological, and molecular studies of C. longa are reviewed. The rhizome is rich in essential oils, and various numbers of chemical constituents with biomedical significance have been isolated from it. The management of indigenous knowledge by appropriate documentation is recommended. This review was compiled to provide recent consolidated information covering different aspects of the plant, phytochemical, pharmacological, and molecular study to provide a basis on which to plan future studies and to promote sustainable use of C. longa.

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Section: Antidepressant Properties and Effect On Nervous Systemmentioning

confidence: 99%

Untitled

Ashraf¹

2017

IJGP

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“…Betterment in the Inventory of Depressive Symptomatology self-rated version (IDS-SR30) was employed as the primary outcome. [52] The secondary outcomes used to assess effect of curcumin were IDS-SR30 factor scores and the Speilberger State-Trait Anxiety Inventory (STAI).Though there was no significant difference between the two groups in the first four weeks in decreasing depressive and anxiety symptoms , from week 4 to 8,the curcumin group was more efficacious than placebo in bringing down both depressive and anxiety symptoms as shown by improvement in IDS-SR30 total score and IDS-SR30 mood score [52] Curcuma longa was found to inhibit MAO A in mouse brain, which is responsible for its antidepressant effects [53].…”

Section: Curcumin On Depression:-mentioning

confidence: 99%

“…[53] Curcumin was found to exert its antidepressant effects in mice by interacting with serotonergic receptors 5-HT1 and 5-HT2. [54] 2754…”

Section: Curcumin On Depression:-mentioning

confidence: 99%

The Pleiotropic Effects of Curcumin.

Srinivasan¹,

Selvarajan²,

Dkhar³

2017

IJAR

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“…possess anti-inflammatory properties [26,27]. Conversely, there has been use of antidepressant amitriptyline in therapy of chronic tension headache [28].…”

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confidence: 99%

Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats

Bhatt

Shukla

Raval

et al. 2016

Basic Clin Pharma Tox

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A large number of current studies indicate that inflammatory mediators may contribute to depression in experimental models as well as in human beings. Nevertheless, the subject, whether anti-inflammatory treatments can prevent depression still remains controversial. In the present study, a chronic mild stress (CMS) model of male Sprague Dawley rats was used to investigate the role of anti-inflammatory drugs in the treatment of depression. All the animals in different groups, except the normal control group, were exposed to CMS procedure for 28 days and concurrently treated with aspirin (10 mg/kg, p.o.), dexamethasone (1 mg/kg p.o.) and amitriptyline (10 mg/kg p.o., reference standard), respectively. Amitriptyline was also used in combination with aspirin and dexamethasone to inspect any synergistic effects. Tests performed towards the end of the study included sucrose preference test, behavioural tests like forced swim test, elevated plus-maze, light/dark box, locomotor activity and biochemical estimations like serum cortisol and brain neurotransmitters. Disease control group (CMS-treated) produced significant depressive behaviour in rats. The animals treated with aspirin showed increased sucrose preference, decreased immobility time in forced swim test, decreased serum cortisol and increased brain serotonin levels signifying antidepressant action. In contrast, there was aggravation of depressive behaviour in rats treated with dexamethasone. Together, these findings suggest that aspirin can serve as a potential antidepressant both individually and as adjunctive agent in the treatment of depression. Inhibition of the inflammatory mediators during stress procedures or any other potential physiological and biochemical mechanisms may be involved in its antidepressant effect.Major depression is one of the most commonly diagnosed neuropsychiatric disorders, with a worldwide life-time prevalence of 17%. It is estimated that by 2020, major depression will be the second most disabling condition in the world. Despite considerable strides have been made over the years, treatment-resistant depression (TRD) remains a common condition which accounts for approximately 30% of the depressed population [1,2]. Historically, treatment options for depression and associated disorders have focused on the medications that modify the activity of monoamine neurotransmitter systems [3].Several studies support the role of inflammation and immune system deregulation in pathophysiology of depression [4,5]. Patients with major depression have been found to exhibit all of the vital features of inflammation, including elevation of inflammatory cytokines, acute phase proteins, chemokines, adhesion molecules and inflammatory mediators such as prostaglandins. Repeated administration of IL-1, TNF-a and IL-6 elicits depressive-like behaviour in animals [6][7][8]. The mechanisms contributing to pathogenesis of depression incorporate abnormal neurotransmitter metabolism, altered neuro-endocrine functions and distorted neural plasticity [9,10...

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Antidepressant activity of aqueous extracts of Curcuma longa in mice

Cited by 212 publications

References 18 publications

Untitled

Untitled

The Pleiotropic Effects of Curcumin.

Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats

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