Antidepressant Action of Harmine Hydrochloride

Nurmaganbetov, Zh. S.; Arystan, Leila I.; Турмухамбетов, А. Ж.; Анаев, Алишер Анаевич; Воронина, Т. А.; Sariev, A. K.; Адекенов, С. М.

doi:10.19163/2307-9266-2014-2-6(7)-96-98

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of provided preclinical surveys is determined that harmine hydrochloride has antidepressant, antihypoxic (hypobaric hypoxia), activating (in 2.5 mg per kg dose in actometer) and antiparkinsonianeffects. Harmine hydrochloride in 2.5 mg/kg (in some tests in 5 mg/kg) eliminates catalepsy, caused by haloperidol among rats, decreasesoligokinesia and rigidity in the Parkinson syndrome test, which was stimulated by 1-methyl-4-phenil-1,2,3,7-tetrahydropyridine (MFTP) neurotoxin to C57BL/6 mice line, but doesn`t effect on tremor, caused by arecoline or MFTP.The antiparkinsonian action is realized due to inhibition of monoamine oxidase as well as antagonism to GABA receptors [38][39][40] . The purpose of this research was to study the chronic toxicity of the drug "Harmine hydrochloride, capsules".…”

Section: Introductionmentioning

confidence: 99%

Experimental research of Harmine hydrochloride effect on internal organs

Zhanaidarova

Yessimova

Nurseitova

et al. 2019

Bangladesh J Med Sci

View full text Add to dashboard Cite

Objective. The purpose of thisstudy was to determine the chronic toxicity of the drug “Harmine hydrochloride, capsules” for preclinical evaluation of its safety. Materials and methods.The experiment was performed on 48 CD-1 rats. Harmine hydrochloride was injectedto the animals intragastrically at doses of 2.5 mg / kg/per day, 5 mg / kg/per day, 9 mg / kg/per day, 10 mg / kg/per day for 3 months. After 3 months, the animals were withdrew from the experiment, internal organs (brain, heart, spleen, adrenals) were weighed and set in 10% neutral formalin. Histological specimenswere mounted in accordance with standard procedures. Results and Discussion. All morphological, histopathological changes, in addition to mortality and bodyweight changes were recorded.Microtome cuts, 5 micrometers thick, were stained with hematoxylin and eosin. Conclusion. As a result of the morphological study, there was no toxic effect of harmine hydrochloride at doses of 2.5 mg / kg, 5 mg / kg, 9 mg / kg and 10 mg / kg on the brain, at doses of 2.5 mg / kg and 5 mg / kg on the structure of the heart, spleen and adrenal glands. At doses of 9 mg / kg and 10 mg / kg, there is an initial toxic dose-dependent effect on the heart, spleen and adrenal glands. Bangladesh Journal of Medical Science Vol.18(3) 2019 p.598-606

show abstract

Section: Introductionmentioning

confidence: 99%

Experimental research of Harmine hydrochloride effect on internal organs

Zhanaidarova

Yessimova

Nurseitova

et al. 2019

Bangladesh J Med Sci

View full text Add to dashboard Cite

show abstract

Сontent of Alkaloids in Different Organs of Peganum Harmala L. During Ontogenesis

Kruglov,

Velichko,

Yusupbayeva

2023

JCPRM

View full text Add to dashboard Cite

Peganum garmala contains in its composition quinazoline (L-peganine (vasicin), pegamine, peganol, deoxypeganine, peganidin, etc.) and β-carboline (harmine, harman, harmaline, harmalol, etc.) alkaloids, which also cause different pharmacological activity harmala preparations. The accumulation of alkaloids depends on the stage of ontogenesis and differs in the aboveground and underground parts of the plant. The aim of the work is to determine the possibility of using various plant organs for the isolation of individual alkaloids. The study was conducted on the underground and aboveground organs of a plant collected on the territory and the Republic of Kyrgyzstan in the phases of vegetation, flowering and fruiting. Using thin-layer chromatography and spectrophotometry, it was found that the alkaloid peganine predominates in the aerial part of the plant. In the roots in the phase of vegetation and flowering, harmine predominates, while in the fruiting phase it is absent and only peganine is recorded. Quantitative determination of the content of both alkaloids was carried out by measuring the optical density at wavelengths characteristic of the extremums of peganine (266 nm) and harmine (315 nm). As a result, it was found that the content of peganin in the aboveground organs of the common harmala does not depend on the stage of ontogenesis. At the same time, the content of alkaloids in harmala roots decreases in ontogeny with a simultaneous change in the ratio of harmine and peganine – harmine predominates in the vegetation and flowering stages, and in the fruiting stage, its content decreases to a trace level with a simultaneous increase in the content of peganine.

show abstract

Antidepressant Action of Harmine Hydrochloride

Abstract: The articles presents the results of antridepressant action of water-soluble form of harmine hydrochloride.

Cited by 2 publications

References 0 publications

Experimental research of Harmine hydrochloride effect on internal organs

Experimental research of Harmine hydrochloride effect on internal organs

Сontent of Alkaloids in Different Organs of Peganum Harmala L. During Ontogenesis

Contact Info

Product

Resources

About