“…Anti-CCP antibodies cannot be considered as pathognomonic for RA, as they are also detected in other disease entities such as palindromic rheumatism, psoriatic arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren’s syndrome, polymyositis, dermatomyositis, ulcerative colitis, HCV seropositive patients with arthralgia and also in some infectious diseases [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Furthermore, anti-CCP antibodies are detected in apparently healthy individuals and blood donors with a frequency of about 1% [ 23 ].…”