Anticonvulsive Effect of Swim Stress in Mice

Peričić, Danka; Švob, Dubravka; Jazvinšćak, Maja; Mirković, Kety

doi:10.1016/s0091-3057(00)00267-7

Cited by 50 publications

(23 citation statements)

References 46 publications

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“…Our results support other studies reporting that stressful manipulations in rodents decrease the convulsant potency of GABA-related compounds, suggesting an enhancement of the brain GABA system function (Soubrie et al 1980;Skerritt et al 1981;Schwartz et al 1987;Miller et al 1987;Abel and Berman 1993;Pericic et al 2000). Several authors have reported a release of neuroactive steroids in plasma and in the brain after various acute stressors in rats (Purdy et al 1991;Barbaccia et al 1996) and in mice (Mele et al 2004) consistent with the present results.…”

Section: Discussionsupporting

confidence: 93%

“…The finasteride dose used in the present experiment has been reported to cause a fall in plasma and in brain allopregnanolone levels in the order of 65-75% Rhodes and Frye 2001;Verleye et al 2005). Our observations are consistent with the previous studies of Reddy and Rogawski (2002) but differ from those of Pericic et al (2000). Indeed, the latter authors have shown that finasteride failed to affect the onset of convulsions of GABA-related compounds such as picrotoxin and pentylenetetrazole in mice (CBA strain).…”

Section: Discussionsupporting

confidence: 92%

“…Some studies have shown that stressful manipulations in rodents are associated with anticonvulsant effects against seizures induced by various GABA A receptors antagonists (Soubrie et al 1980;Abel and Berman 1993;Pericic et al 2000).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABAA-related mechanistic probes

2008

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These findings support the hypothesis suggesting an involvement of neuroactive steroids in the anticonvulsive effect of restraint stress. The dual and complementary mechanisms of action of etifoxine (directly on the GABA A receptor and indirectly via the neuroactive steroids) may represent a therapeutic benefit in the treatment of various anxiety disorders with abnormal production of neuroactive steroids.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

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Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABAA-related mechanistic probes

2008

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“…pre-treatment with aminoglutethimide (a mitochondrial inhibitor p450 scc) was conducted in order to suppress increase of endogenous corticosteroids during the exercise protocol 21 . The results …”

Section: Discussionmentioning

confidence: 99%

Evidências de que um protocolo de atividade física pode reduzir a contagem de leucócitos sinoviais de ratos artríticos

Gomes

Bressan

Silva

et al. 2013

Rev Bras Med Esporte

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ABSTRACTintroduction: physical activity is thought to be beneficial to arthritis, delaying disability and/or improving joint function. in vivo studies using experimental models of arthritis may provide useful information about such benefits. Objective: The aim of the present study was to evaluate the effects of the low-intensity exercise on a model of CFA-induced arthritis in rats. Methods: Articular incapacitation was measured by the paw elevation time in 1-min periods of stimulated walk. Edema was evaluated by the knee-joint diameter. Synovial exudate was sampled after 10 days for leukocyte count. The exercise protocol consisted of a 2-min period of stimulated walk in the 1st day, 10 min in the 2nd day, and 20 min from the 3rd to the 10th day; The control animals were submitted to 1-min period of stimulated walk once a day over 10 days. Corticosteroid involvement was assessed by treating the animals with aminoglutethimide. Results: The exercise protocol produced a slight but sustained reduction of disability and joint swelling associated with a large reduction in the synovial leukocyte count. Aminoglutethimide only prevented the effect on synovial leukocyte count. Conclusion: These results suggest that a low-intensity physical activity does not aggravate the symptoms of arthritic animals, in fact showing a slight improvement, and still can markedly reduce the migration of leukocytes into the synovial space.

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“…Later studies in mice demonstrated that acute swim stress lowers the convulsive potency of GABA-related and some GABA-unrelated convulsants (Peričić et al 2001a). The anticonvulsant effect of stress could not be counteracted by flumazenil, an antagonist of benzodiazepine binding sites (Peričić and Bujas 1997), by adrenalectomy (Peričić et al1999), or by drugs interfering with the synthesis of steroids (Peričić et al 2000). However, the anticonvulsive effect of stress was reduced by yohimbine and idazoxan, two a 2 -adrenoceptor antagonists, and potentiated by clonidine, an a 2 -adrenoceptor agonist, suggesting that a 2 -adrenoceptors are involved in the anticonvulsive effect of swim stress in mice (Peričić et al 2001b).…”

Section: Introductionmentioning

confidence: 99%