Anticonvulsants. I. Dibenzo[a,d]cycloheptadiene-5-carboxamide and Related Compounds

Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants

“…Of the total of 37 urea derivatives of phenothiazine prepared, 22 compounds (1, 40 For the procedure for synthesis of phenothiazine ureas, typically, a mixture of phenothiazine-10-carbonyl chloride (1.00 g, 3.82 mmol), and amine (9.55 mmol) in CH 2 Cl 2 (40 mL) was stirred at room temperature until analysis by thin layer chromatography revealed no unreacted phenothiazine-10-carbonyl chloride remained, or no further change was observed. All reactions were monitored using thin layer chromatography (TLC) which was performed on Macherey Nagel Polygram Ò Sil G/UV 254 precoated silica plates (0.20 mm thickness).…”

Comparison of Anticonvulsant Potencies of Cyheptamide, Carbamazepine, and Phenytoin

“…Although several reports (6)(7)(8) have dealt with the pharmacological properties of cyheptamide, the procedures employed do not permit direct comparison of its anticonvulsant activity with that of carbamazepine, phenytoin, and other structurally related anticonvulsants. The present investigation presents such data for comparative purposes.…”

Thermochemistry and quantum chemical calculations of two dibenzocycloalkane nitriles

“…Information about the chemistry of nitrogen containing derivatives of dibenzocycloheptane and dibenzo-cyclooctane may be found in references [12][13][14][15][16][17][18]. Samples of both compounds were analyzed by gas chromatography and found to be over 99.9% pure.…”