Anticonvulsant properties of saponins from Ficus platyphylla stem bark

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

“…20 Saponin containing plant extracts have inhibited pentylenetetrazole induced seizures. 21 Phytochemical analysis of water extract of leaves of this plant has shown presence of saponins. 22 Hence, the aim of this study was to evaluate anticonvulsant property of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats.…”

Anticonvulsant activity of extracts from six Cameroonian plants traditionally used to treat epilepsy

“…The PTZ model is assumed to identify anticonvulsant drugs effective against petit mal seizures. The effects of extracts against PTZ-induced seizures thus suggest anticonvulsant efficacy against petit mal epilepsy in man (Chindo et al, 2009).…”

“…Similarly, the saponin fraction of the same plant at 1 mg/kg was able to decrease PTZ-induced seizures (Singh et al, 2013). Another species, Ficus platyphylla, studied by Chindo et al (2009) revealed that saponins extracted from the stem bark, tested at the minimal dose (25 mg/kg) were effective against in vivo and in vitro models of epilepsy. In our study, leaves and stem bark of F. thonningii at 200 mg/kg, the smallest dose tested, significantly delayed the onset of seizures in general and tonicoclonic seizures in particular.…”

“…Clonic seizures induced by PTZ are blocked by drugs that reduce T-type calcium currents and drugs that enhance inhibitory neuro-transmission by GABAA receptors (benzodiazepine, phenobarbital and valproate) (Chindo et al, 2009). The fact that the extracts protected animal against PTZ-induced seizures may suggest that they contain compounds that facilitate GABAergic transmission (Ayanniyi and Wannang, 2008).…”

“…Medicinal plants are believed to be an important source of new drugs and lead compounds with potential therapeutic effects. The inclusion of those with proven safety and efficacy in the healthcare programs of developing countries is encouraged by the WHO because of the great potential they possess in combating various diseases (Chindo et al, 2009). Several plants used for the treatment of epilepsy in different systems of traditional medicine have shown activity when tested in modern bioassays for the detection of anticonvulsant activity (Hedge et al, 2009).…”