Anticonvulsant properties of Euterpe oleracea in mice

Souza-Monteiro, José Rogerio; Hamoy, Moisés; Santana‐Coelho, Danielle; Arrifano, Gabriela de Paula; Paraense, Ricardo S.O.; Costa-Malaquias, Allan; Mendonça, Jackson R.; Silva, Rafael F. da; Monteiro, Wallena S.C.; Rogez, Hervé; Oliveira, Diogo Lösch de; Nascimento, José Luíz Martins do; Crespo-López, María Elena

doi:10.1016/j.neuint.2015.06.014

Cited by 40 publications

(44 citation statements)

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“…These interactions have been previously demonstrated (e.g., cannabinoid receptor agonists were effective in protecting against pentylenetetrazole-induced seizures) [48]. Currently, PTZ is considered an important model of myoclonic and generalized tonic-clonic seizures for screening therapeutic advances for anticonvulsant compounds [49,50].…”

Section: Discussionmentioning

confidence: 84%

“…Behavioral assessment and electrical recordings are extremely helpful for comparing alterations produced by neuronal excitability that triggers seizures and epileptic conditions [49,50,63]. Our data with FAA1 revealed that on behavioral evaluation, the increased latency and seizure threshold was confirmed by eletrocorticographic (ECoG) recording, since the observation of behavior could not be quantified.…”

Section: Discussionmentioning

confidence: 88%

“…After PTZ injection, animals were monitored for 10 min to the latency time of the first myoclonic spasm and first generalized tonic-clonic seizure, as well as the total duration of tonic-clonic seizures [49,79].…”

Section: Behavioral Seizure Analysesmentioning

confidence: 99%

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Fatty Acid Amides Synthesized from Andiroba Oil (Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic Option

et al. 2020

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Epilepsy is a chronic neurological disease characterized by excessive neuronal activity leading to seizure; about 30% of affected patients suffer from the refractory and pharmacoresistant form of the disease. The anticonvulsant drugs currently used for seizure control are associated with adverse reactions, making it important to search for more effective drugs with fewer adverse reactions. There is increasing evidence that endocannabinoids can pharmacologically modulate action against seizure and antiepileptic disorders. Therefore, the objective of this study is to investigate the anticonvulsant effects of fatty acid amides (FAAs) in a pentylenetetrazole (PTZ)-induced seizure model in mice. FAAs (FAA1 and FAA2) are obtained from Carapa guianensis oil by biocatalysis and are characterized by Fourier Transform Infrared Analysis (FT-IR) and Gas Chromatography-Mass Spectrometry (GC-MS). Only FAA1 is effective in controlling the increased latency time of the first myoclonic jerk and in significantly decreasing the total duration of tonic-clonic seizures relative to the pentylenetetrazol model. Also, electrocortical alterations produced by pentylenetetrazol are reduced when treated by FAA1 that subsequently decreased wave amplitude and energy in Beta rhythm. The anticonvulsant effects of FAA1 are reversed by flumazenil, a benzodiazepine antagonist on Gamma-Aminobutyric Acid-A (GABA-A) receptors, indicating a mode of action via the benzodiazepine site of these receptors. To conclude, the FAA obtained from C. guianensis oil is promising against PTZ-induced seizures.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 88%

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Fatty Acid Amides Synthesized from Andiroba Oil (Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic Option

et al. 2020

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“…Podawanie zwierzętom doświadczalnym przez 4 dni raz na dobę soku z owoców açaí okazało się skutecznie opóźnić moment wystąpienia wywołanego pentetrazolem napadu toniczno-klonicznego i znacząco skrócić całkowity czas jego trwania, kiedy już wystąpił [68]. Surowiec przy stymulowanym pobudzeniu hamował czynność elektryczną mózgu.…”

Section: Inne Aktywności Owoców E Oleraceaunclassified

Açaí – therapeutic capability based on a phytochemical profile and current pharmacological studies

Wojciechowska¹,

Grzegorczyk-Karolak²

2019

Farm Pol.

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Açaí-therapeutic capability based on a phytochemical profile and current pharmacological studies • Euterpe oleracea is a plant native to Central and northern South America. In this area, fruits of the species, called açaí, are traditionally used as a nutrient and as a medicinal raw material. Their health-promoting activities are based on the rich nutritional properties and high content of antioxidants such as anthocyanins, flavonoids and phenolic acids. In recent years, there has been a growing interest in açaí fruit around the world, including our country. In response to this interest, this review summarizes the knowledge on the phytochemistry, use, pharmacological properties and safety of usage of the raw material.

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“…Recently, the potent anticonvulsant properties of açaí ( Euterpe oleracea Martius, family Arecaceae) were demonstrated in an in vivo pentylenetetrazol (PTZ) mouse model [ 2 ]. Açaí is the fruit of a common palm found in the eastern Amazonian floodplains, and its juice is highly consumed in northern Brazil (up to 1 l/day per person) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Clarified Açaí (Euterpe oleracea) Juice as an Anticonvulsant Agent: In Vitro Mechanistic Study of GABAergic Targets

Arrifano

Lichtenstein

Souza-Monteiro

et al. 2018

Oxidative Medicine and Cellular Longevity

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Seizures affect about 50 million people around the world. Approximately 30% of seizures are refractory to the current pharmacological arsenal, so, the pursuit of new therapeutic alternatives is essential. Clarified Euterpe oleracea (EO) juice showed anticonvulsant properties similar to diazepam in an in vivo model with pentylenetetrazol, a GABAA receptor blocker. This study investigated the effects of EO on the main GABAergic targets for anticonvulsant drugs, analyzing the effect on the GABA receptor's benzodiazepine and picrotoxinin binding sites and the GABA uptake. Primary cultures of cortical neurons and astrocytes were treated with EO (0–25%) for up to 90 min. [3H]Flunitrazepam and [3H]TBOB binding, [3H]GABA uptake, cell viability, and morphology were assayed. Nonlethal concentrations of EO increased agonist binding and decreased antagonist binding in cortical neurons. Low concentrations significantly inhibited GABA uptake, especially in astrocytes, suggesting an accumulation of endogenous GABA in the synaptic cleft. The results demonstrate, for the first time, that EO can improve GABAergic neurotransmission via interactions with GABAA receptor and modulation of GABA uptake. Understanding these molecular mechanisms will help in the treatment of seizures and epilepsy, especially in developing countries where geographic isolation and low purchasing power are the main barriers to access to adequate treatment.

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Anticonvulsant properties of Euterpe oleracea in mice

Cited by 40 publications

References 32 publications

Fatty Acid Amides Synthesized from Andiroba Oil (Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic Option

Fatty Acid Amides Synthesized from Andiroba Oil (Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic Option

Açaí – therapeutic capability based on a phytochemical profile and current pharmacological studies

Clarified Açaí (Euterpe oleracea) Juice as an Anticonvulsant Agent: In Vitro Mechanistic Study of GABAergic Targets

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