2013
DOI: 10.1016/j.bmc.2012.12.051
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Anticonvulsant evaluation of aminoalkanol derivatives of 2- and 4-methylxanthone

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Cited by 21 publications
(15 citation statements)
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“…We also have published derivatives of xanthone exhibiting anticonvulsant activity in maximal electroshock (MES) seizures in mice or rats, with aminoalkanol moieties such as R,S ‐6‐chloro‐2‐{[(1‐hydroxypropan‐2‐yl)amino]methyl}‐9 H‐ xanthen‐9‐one (III), ( S )‐6‐chloro‐2‐{[(1‐hydroxybutan‐2‐yl)amino]methyl}‐9 H‐ xanthen‐9‐one (IV), and without aminoalkanol moieties, such as 2‐[(4‐benzylpiperazin‐1‐yl)methyl]‐6‐methoxy‐9 H‐ xanthen‐9‐one (V) (Figure ) . So far, according to our experience, position of substituents in the xanthone rings plays crucial role and the most active compounds III–V contain substituents at positions C2 and C6 of the xanthone structure.…”
mentioning
confidence: 99%
“…We also have published derivatives of xanthone exhibiting anticonvulsant activity in maximal electroshock (MES) seizures in mice or rats, with aminoalkanol moieties such as R,S ‐6‐chloro‐2‐{[(1‐hydroxypropan‐2‐yl)amino]methyl}‐9 H‐ xanthen‐9‐one (III), ( S )‐6‐chloro‐2‐{[(1‐hydroxybutan‐2‐yl)amino]methyl}‐9 H‐ xanthen‐9‐one (IV), and without aminoalkanol moieties, such as 2‐[(4‐benzylpiperazin‐1‐yl)methyl]‐6‐methoxy‐9 H‐ xanthen‐9‐one (V) (Figure ) . So far, according to our experience, position of substituents in the xanthone rings plays crucial role and the most active compounds III–V contain substituents at positions C2 and C6 of the xanthone structure.…”
mentioning
confidence: 99%
“…Xanthones are known for their multifocal biological properties including antibacterial and antifungal activities. The antimycobacterial, anti‐ Helicobacter and antifungal activities of some of these compounds have been already confirmed. In our previous work, we focused on searching for xanthones with antimicrobial activity.…”
Section: Introductionmentioning
confidence: 89%
“…This work was supported financially by grants from the National Natural Science Foundation of PRC (21002015) Xanthone, also named as dibenzo-γ-pyrone, is a fundamental structural framework of active ingredients in many medicinal plants, which derivatives have broad pharmacological activities, such as antioxidant (Cheng et al, 2011), antitumor (Sousa et al, 2009), anticonvulsant (Szkaradek et al, 2013) and inhibition of neuraminidase activity (Dao et al, 2012). The title compound in this study is a new xanthone derivative, which was synthesized by bromination of 1,3dihydroxy-xanthen-9-one (Liu et al, 2006) with NBS.…”
Section: Data Collectionmentioning
confidence: 99%