Anticonvulsant effects of<i>Calotropis procera</i>root in rats

Jalalpure, Sunil; Salahuddin, M.; Shaikh, Matin; Manvi, F. V.

doi:10.1080/13880200802437008

Cited by 22 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 It also has antiinflammatory and anticonvulsant actions. 17,18 The root extract inhibited both pentylenetetrazole and maximal electroshock seizures. Hepatoprotective effect has been exhibited by flowers.…”

mentioning

confidence: 99%

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

Ramachandra

Shenoy

Madhyastha

et al. 2016

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

mentioning

confidence: 99%

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

Ramachandra

Shenoy

Madhyastha

et al. 2016

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

“…While, Calotoxin has GLIDE score of -11.23 and bond strength of -2.51 Å ( Figure 1B and 4), also Quercetin-3-rutinoside has GLIDE score of -11.21 and bond strength of -0.66 Å showed interaction comparable with Aricept-AChE complex. This binding study may predict mode of action and active chemical moiety from Calotropis procera latex responsible for AChE inhibition and its claim to possesses anti-amnesic 14 , anti-convulsant 15 and neuroprotective effects. 16 Among the selected compounds from seeds of Brassica campestris, Vitamin A showed GLIDE score -11.02 and bond strength -5.54 Å (Figure 2A and 4) while Glucobrassicin (Glucosinolate) has GLIDE score of -10.85 and bond strength of -4.0 Å ( Figure 2B and 4) which denotes tight binding and high energies when compared with Aricept-AChE complex.…”

Section: Resultsmentioning

confidence: 99%

Molecular Docking Study of Cassia tora, Brassica campestris and Calotropis procera as Acetylcholinesterase Inhibitor.

H¹,

D²,

R³

et al. 2016

IJPER

View full text Add to dashboard Cite

Introduction: Acetylcholinesterase inhibitor is the only standard and FDA approved drug therapy for Alzheimer's disease and its associated disorders. Numerous plants and their phytoconstiuents are being reported to inhibit acetylcholinesterase. To get insight of the intermolecular interactions, the molecular docking studies are performed at active site of acetylcholinesterase enzyme. Aim: In this study, an attempt is made for identification of potential ligands from selected 30 compounds which are reported to be present in Cassia tora, Brassica campestris and Calotropis procera, targeted against acetylcholinesterase using molecular modelling and docking studies. Results: The relative binding affinity of the compounds towards AChE was selected on the basis of docking score, GLIDE score and interaction patterns.Several compounds showed stronghydrogen bonding to several important amino acid residues andtheir hydrophobic interactions could also explain their potency to inhibit acetylcholinesterase. These compoundsbelong to different classes like flavonoids, vitamin, cardenolides and etc. Some of these compounds have been reported for their beneficial effect on dementia related disorders, while remaining are suggested to be potential acetylcholinesterase inhibitors. Conclusion: Hence, this study provides evidencefor consideration of valuable ligand molecule as potential acetylcholinesterase inhibitorandfurther in vitro and in vivo investigations may prove its therapeutic potential

show abstract

“…The incidence and prevalence of epilepsy varies with age (Banerjee et al, 2009) and is highest among children below 7 years of age and in individuals of above 55 years (Jalalpure et al, 2009). In India, the prevalence of epilepsy is about 5.5 to 7.9 per 1000 people, which is about 1/18th of the world population (Nag, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Effectiveness of these drugs does not hold true with the entire range of population suffering from this disorder and they are unable to control epileptic seizures in as many as 25% of patients (Jalalpure et al, 2009). In developing countries the treatment of epilepsy is inaccessible and unaffordable (Ojewole, 2008).…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant activity of solasodine isolated fromSolanum sisymbriifoliumfruits in rodents

Chauhan

Sheth

Ranpariya

et al. 2010

Pharmaceutical Biology

View full text Add to dashboard Cite

Anticonvulsant effects ofCalotropis proceraroot in rats

Cited by 22 publications

References 18 publications

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

Evaluation of effect of aqueous extract of leaves of Calotropis procera in pentylenetetrazole induced seizures in rats

Molecular Docking Study of Cassia tora, Brassica campestris and Calotropis procera as Acetylcholinesterase Inhibitor.

Anticonvulsant activity of solasodine isolated fromSolanum sisymbriifoliumfruits in rodents

Contact Info

Product

Resources

About