Anticonvulsant effect of a natural compound α,β-epoxy-carvone and its action on the nerve excitability

Almeida, Reinaldo Nóbrega de; Sousa, Damião Pergentino de; Nóbrega, Franklin Ferreira de Farias; Claudino, Fladmir de Sousa; Araújo, Demétrius Antônio Machado de; Leite, José Roberto; Mattei, Rita

doi:10.1016/j.neulet.2008.07.037

Cited by 49 publications

(37 citation statements)

References 34 publications

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“…The isolated sciatic nerve is a neural preparation that is especially useful for studying the effects of drugs on electrical activity arising from nervous tissue in vitro (Docherty et al, 2005;Almeida et al, 2008). Fig.…”

Section: Resultsmentioning

confidence: 99%

Rosewood oil induces sedation and inhibits compound action potential in rodents

Almeida

Araújo

Gonçalves

et al. 2009

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Rosewood oil induces sedation and inhibits compound action potential in rodents

Almeida

Araújo

Gonçalves

et al. 2009

Journal of Ethnopharmacology

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“…Our report suggests that cyano-carvone used in the present experiment can be administered to humans, protecting them from damage to the nervous system, without evidence of detrimental effects. Like epoxy-carvone (Almeida et al 2008), the protective effect on the nervous system occurs after convulsions induced chemically by maximal electroshock, picrotoxin and pentylenetetrazole receiving the highest concentrations of monoterpene monocyclic after systemic administration (Almeida et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant and Antioxidant Effects of Cyano-carvone and Its Action on Acetylcholinesterase Activity in Mice Hippocampus

et al. 2012

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The anticonvulsant effect of cyano-carvone, a monoterpene monocyclic, was investigated in epilepsy model induced by pilocarpine. Cyano-carvone at doses of 25, 50 or 75 mg/kg promoted a reduction of 16.7, 33 and 66.7%, respectively, against pilocarpine-induced seizures, and it was efficacious in increasing both the latency to first seizures and the survival percentage, resulting in 33.3, 67 and 91.7% of protection against death induced by seizures, respectively (P < 0.05). The reference drug atropine (25 mg/kg) also produced a significant protection (100%). Its monoterpene, at 25, 50 and 75 mg/kg, was also capable to increase the latency for installation of status epilepticus induced by pilocarpine, and presented a significant protection against lipid peroxidation and nitrite formation in mice hippocampus (P < 0.05). In addition, it was observed that the cyano-carvone pretreatment increased the acetylcholinesterase activity in mice hippocampus after pilocarpine-induced seizures. The present results clearly indicate the anticonvulsant ability of cyano-carvone, which can be, at least in part, explained by the increased activity of the acetylcholinesterase enzyme. Our data suggest that the action mechanism can also be due to a direct activation of the antioxidant enzymes that could be associated with a reduction observed in oxidative stress in mice hippocampus, probably involving an inhibition of free radical production.

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“…15) There are several reports on the antioxidant effects of terpenoids. 13,22) These terpenoids and their combinations might also be important factors responsible for the enhanced inhibition of tyrosinase activity and melanin biosynthesis in B-16 melanoma cells and a human reconstructed skin model. In summary, this study suggests that four types (the A-type, AB-type, D-type, and G-type) of phytoncide solution showed inhibitory effects on tyrosinase activity and melanin biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

“…The physiological effects of terpenoids have been well studied in a medical content. It is reported that monoterpenoids have disinfection effects, 11) an analgesic effect, 12) and anticonvulsant and antioxidant effects, 13) and it has also been reported that sesquiterpenoids enhance the effects of anti-cancer agents. 14) Moreover, it was reported that phytoncide solutions provide refreshing effects and antibacterial effects, and inhalation of them is known as forest bathing and aromatherapy.…”

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confidence: 99%

Inhibitory Effects of Phytoncide Solution on Melanin Biosynthesis

Fujimori

Hisama

Shibayama

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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To determine the component-activity relationships of phytoncide solutions on inhibitory activity in melanin biosynthesis, four types of phytoncide solution (A-type, AB-type, D-type, and G-type) were evaluated for inhibition of mushroom tyrosinase activity and melanin synthesis on murine B-16 melanoma cells and a human reconstituted skin model. The A-type, AB-type, D-type, and G-type of phytoncide solution treatment resulted in significant inhibition of tyrosinase activity. The amount of melanin was increased by treatment with phytoncide solutions in a concentration-dependent manner on murine B-16 melanoma cells without affecting cell growth. Furthermore, phytoncide solutions also suppressed melanin synthesis in a concentration-dependent manner on a human reconstituted skin model. These effects of A-type solution were superior to those of other solutions.

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Anticonvulsant effect of a natural compound α,β-epoxy-carvone and its action on the nerve excitability

Cited by 49 publications

References 34 publications

Rosewood oil induces sedation and inhibits compound action potential in rodents

Rosewood oil induces sedation and inhibits compound action potential in rodents

Anticonvulsant and Antioxidant Effects of Cyano-carvone and Its Action on Acetylcholinesterase Activity in Mice Hippocampus

Inhibitory Effects of Phytoncide Solution on Melanin Biosynthesis

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