Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch.

Mandegary, Ali; Arab-Nozari, Milad; Ramiar, Hoorieh; Sharififar, Fariba

doi:10.1016/j.jep.2012.01.024

Cited by 46 publications

(26 citation statements)

References 21 publications

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“…Maximal electroshock seizure (MES) test was carried out according to the previously reported methods with some modifications [17]: an alternating current stimulus (50 mA; 50 Hz; 1 s duration) was used. Mice were pretreated with matrine (7.5, 15, 30 and 60 mg/kg), phenytoin (20 mg/kg), and normal saline (20 mL/kg) by intraperitoneal injection (ip), and after 30 min, electroshock was administered.…”

Section: Methodsmentioning

confidence: 99%

“…30 min after treatment, mice in all groups were administered PTZ (90 mg/kg) subcutaneously (sc). Mice were observed within 60 min, and 5 different types of seizure stages were divided by the criterions of Racine’s scale [17,18], including: (stage 1) one or more mouth and facial twitches; (stage 2) rhythmicity head nodding; (stage 3) forelimb clonus; (stage 4) seizures characterized by rearing or hind limb extension; (stage 5) seizures with rearing and repeated falling.…”

Section: Methodsmentioning

confidence: 99%

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Antiepileptic Potential of Matrine via Regulation the Levels of Gamma-Aminobutyric Acid and Glutamic Acid in the Brain

Xiang

Jiang

2013

IJMS

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Our present study aimed to determine the antiepileptic activity of matrine, and explore the possible molecular mechanism. To evaluate the antiepileptic activity of matrine, seizures in mice induced by PTZ and MES were established, then the pentobarbital sodium-induced anaesthetizing time and locomotor activity tests in mice were also carried out. For the molecular mechanism investigations, contents of aspartic acid (Asp), gamma-aminobutyric acid (GABA), glutamic acid (Glu), glycine (Gly) in seizures mice were determined; then, the chronic seizures rats induced by PTZ were prepared, and western blotting was used to determine the expressions of GAD 65, GABAA and GABAB in the brains. In the results, matrine showed significant antiepileptic effects on seizures mice induced by MES and PTZ. Moreover, the pentobarbital sodium-induced anaesthetizing time and locomotor activity tests were also demonstrated that matrine had obvious antiepileptic effects. Additionally, our results revealed that after treatment with matrine, contents of GABA can be elevated, and the contents of Glu were obviously decreased. Furthermore, western blotting revealed that the mechanism regarding the antiepileptic effect of may be related to the up-regulations of GAD 65 and GABAA in the brain. Collectively, we suggested that matrine can be developed as an effective antiseptic drug.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Antiepileptic Potential of Matrine via Regulation the Levels of Gamma-Aminobutyric Acid and Glutamic Acid in the Brain

Xiang

Jiang

2013

IJMS

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“…Bearing in mind the fact that the screening procedure used in our previous studies was sensitive enough to detect the anticonvulsant action of xanthotoxin, osthole and imperatorin, we attempted to perform the screening test in order to detect the anticonvulsant action of substances isolated from various herbs and medicinal plants. There is no doubt that herbs and plants are the perfect source of active agents that could be used in patients with epilepsy [6,7,8,9,10,11,12,13,14]. On the other hand, pharmaceutical companies and industries are able to create novel compounds more effective than their natural counterparts due to the selective and rational modification of chemical structure of the investigated compounds.…”

Section: Discussionmentioning

confidence: 99%

“…It has recently been documented that essential oils isolated from various medicinal plants and herbs, such as Artemisia dracunculus, Eugenia caryophyllata, Pimpinella anisum, Ascorus tatarinowii, Cymbopogon citratus, Bunium persicum, Ferula gummosa and Zhumeria majdae exerted anti-convulsant activity in the maximal electroshock (MES)induced seizure model in mice [6,7,8,9,10,11,12,13,14]. There is no doubt that the screening test allowing identification of the active compounds naturally occurring in herbs and medicinal plants should be performed in experimental animal studies.…”

Section: Introductionmentioning

confidence: 99%

Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice

Łuszczki

Włodarczyk

Gleńsk

et al. 2013

J Pre Clin Clin Res.

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Introduction and objective: The study was aimed at performing the anticonvulsant screening test to select some naturally occurring substances isolated from herbs and medicinal plants that could suppress seizures in the maximal electroshock (MES)-induced tonic seizure model in mice. Materials and methods: The screening test was performed for 10 natural substances (alizarin, betulin, curcumin, diosmin, linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin) administered intraperitoneally in a constant dose of 300 mg/kg at various pre-treatment times (15, 30, 60 and 120 min.) before the MES test. Results: Only α-terpineol and vanillin produced a 12.5% protection against MES-induced tonic seizures in mice, when administered i.p. at 120 and 60 min., prior to the MES test, respectively. In contrast, the remaining substances (alizarin, betulin, curcumin, diosmin, linalool, menthofuran, theobromine and β-thujaplicin) produced no anti-convulsant activity after their i.p. administration to mice. Conclusions: α-Terpineol and vanillin are worth considering as potentially favorable compounds in experimental epileptology.

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“…The B. persicum exhibits antimicrobial (20), antifungal (21), antioxidant (22), α-amylase inhibitory (23), anticonvulsant (24), antinociceptive, anti-inflammatory (25) and antihistaminic (26) effects.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on Mushroom Tyrosinase

Namjoyan

Jahangiri

Azemi

et al. 2015

Jundishapur J Nat Pharm Prod

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Background:The key enzyme in the process of melanin biosynthesis is tyrosinase. Skin hyperpigmentation and browning of foods are undesirable phenomena which tyrosinase represents. Therefore, tyrosinase inhibitors have been used increasingly for medicinal and cosmetic products. Objectives: In this study, inhibitory effects of four plants including: physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on diphenolase activity of mushroom tyrosinase were evaluated. Materials and Methods:The inhibitory activities of hydroalcoholic extracts of plants against oxidation of L-Dopa (as a substrate) by mushroom tyrosinase were investigated. Results: The hydroalcoholic extract of P. alkekengi showed the most tyrosinase inhibitory effect with IC50 of 0.09 mg/mL vs. 0.38, 0.38 and 2.82 mg/mL of B. persicum, A. rosea and M. vulgare, respectively. M. vulgare exhibited uncompetitive inhibition and other plants showed mixed type inhibition on mushroom tyrosinase. Conclusions: All plants could inhibit mushroom tyrosinase, but more investigations on human tyrosinase and clinical studies are needed.

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Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch.

Cited by 46 publications

References 21 publications

Antiepileptic Potential of Matrine via Regulation the Levels of Gamma-Aminobutyric Acid and Glutamic Acid in the Brain

Antiepileptic Potential of Matrine via Regulation the Levels of Gamma-Aminobutyric Acid and Glutamic Acid in the Brain

Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice

Inhibitory Effects of Physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on Mushroom Tyrosinase

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