Anticonvulsant activity of <i>Caryocar coriaceum</i> Wittm. fixed pulp oil against pentylenetetrazol-induced seizures

Oliveira, Cleide Correia de; Oliveira, Clarissa Vasconcelos de; Grigoletto, Jéssica; Ribeiro, Leandro Rodrigo; Funck, Vinícius Rafael; Pereira, Leticia; Fighera, Michele Rechia; Royes, Luiz Fernando Freire; Furian, Ana Flávia; Menezes, Irwin Rose Alencar de; Oliveira, Mauro Schneider

doi:10.1080/01616412.2017.1324380

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…At day 7, animals were subjected to open field, neuroscore, and pick-up test to determine neuromotor performance, locomotion, and anxiety-like behavior. During the days 8 and 9, object recognition test, was carried out to evaluate the short-term and long-term memory. After the long-term memory test, the anxiety-like behavior was measured in the elevated plus maze test at day 9.…”

Section: Methodsmentioning

confidence: 99%

Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na⁺, K⁺-ATPase-Activating Antibody after Status Epilepticus

Mello,

Sampaio,

Neuberger

et al. 2024

ACS Chem. Neurosci.

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Status epilepticus (SE) is a medical emergency associated with high mortality and morbidity. Na + , K + -ATPase, is a promising therapeutic target for SE, given its critical role in regulation of neuron excitability and cellular homeostasis. We investigated the effects of a Na + , K + -ATPase-activating antibody (DRRSAb) on short-term electrophysiological and behavioral consequences of pilocarpine-induced SE. Rats were submitted to pilocarpine-induced SE, followed by intranasal administration (2 μg/nostril). The antibody increased EEG activity following SE, namely, EEG power in theta, beta, and gamma frequency bands, assessed by quantitative analysis of EEG power spectra. One week later, DRRSAb-treated animals displayed less behavioral hyperreactivity in pick-up tests and better performance in novel object recognition tests, indicating that the intranasal administration of this Na + , K + -ATPase activator immediately after SE improves behavioral outcomes at a later time point. These results suggest that Na + , K + -ATPase activation warrants further investigation as an adjunctive therapeutic strategy for SE.

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Section: Methodsmentioning

confidence: 99%

Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na⁺, K⁺-ATPase-Activating Antibody after Status Epilepticus

Mello,

Sampaio,

Neuberger

et al. 2024

ACS Chem. Neurosci.

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“…Oliveira et al [57] evaluated the effect of C. coriaceum oil in the treatment of seizures. In general, the authors first administered the fixed oil from the pulp of C. coriaceum to rats in increasing doses (25, 50 or 100 mg/kg).…”

Section: Other Activitiesmentioning

confidence: 99%

Caryocar coriaceum Wittm. (Caryocaraceae): Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, Extractivism and Conservation Needs

Almeida-Bezerra

Bezerra

Silva

et al. 2022

Plants

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Caryocar coriaceum is an endemic tree of Brazil, occurring mainly in the northeast region in the Cerrado environment. The species, popularly known as “pequi”, produces fruits that are used in the manufacture of oil for food and medicinal purposes. This work reviewed studies conducted with the species, highlighting its ethnomedicinal use, its pharmacological potential, including its chemical constituents, and its cultural and socioeconomic importance. Information was obtained through the main scientific research platforms. The keyword “Caryocar coriaceum” was used as the main index for searching the following platforms: PubMed®, PubMed Central®, SciElo, Scopus® and Web of ScienceTM. The compiled papers demonstrate that C. coriaceum has great medicinal, economic and cultural importance for northeastern Brazil. Popularly, the fruits of C. coriaceum are used to treat broncho-pulmonary diseases (bronchitis, colds and flu). The fixed oil is widely used to relieve pain from various causes in the treatment of inflammation, flu, eczema, burns, fever, rickets, indigestion, heart murmurs, fatigue and erectile dysfunction. Some of these uses are corroborated by pharmacological trials, which have demonstrated the antioxidant, healing, anti-inflammatory, gastroprotective, antinociceptive and antimicrobial properties of the species. Chemically, fatty acids and phenolic compounds are the main constituents recorded for the species. Due to its medicinal properties, the fruits and oil of C. coriaceum have a high commercial demand and are one of the main forms of subsistence activities for local populations. On the other hand, the extractive practice of the fruits, associated with anthropic factors and its physiological nature, makes the species threatened with extinction. Thus, public management policies are highly necessary in order to avoid its extinction.

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“…KEYWORDS: Caryocar coriaceum, ionic gelation, sodium alginate, viscosity. BATISTA et al, 2010;RIBEIRO, 2010;SARAIVA et al, 2011;DE FIGUEIREDO et al, 2016;DE LACERDA NETO et al, 2018;OLIVEIRA et al, 2017;PEREIRA et al, 2019). Estudos revelaram atividade antifúngica do óleo, efeito redutor dos processos inflamatórios e na pressão arterial, ação quimioterápica e propriedades antitumorais (BATISTA et al, 2010;HORN et al, 2014;MIGUEL, 2010).…”

Section: Microencapsulation Of Pequi Oil (Caryocar Coriaceum) Using Aunclassified

EXPRESSÃO DIFERENCIAL DA SUPERÓXIDO DISMUTASE E CATALASE DURANTE A GERMINAÇÃO DE Lactuca sativa L. EXPOSTA A METAIS PESADOS

Neto¹,

Carvalho²,

Govêa³

et al. 2020

A Química Nas Áreas Natural, Tecnológica E Sustentável 3

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. A Atena Editora não se responsabiliza por eventuais mudanças ocorridas nos endereços convencionais ou eletrônicos citados nesta obra. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação.

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Anticonvulsant activity of Caryocar coriaceum Wittm. fixed pulp oil against pentylenetetrazol-induced seizures

Cited by 11 publications

References 30 publications

Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na⁺, K⁺-ATPase-Activating Antibody after Status Epilepticus

Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na⁺, K⁺-ATPase-Activating Antibody after Status Epilepticus

Caryocar coriaceum Wittm. (Caryocaraceae): Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, Extractivism and Conservation Needs

EXPRESSÃO DIFERENCIAL DA SUPERÓXIDO DISMUTASE E CATALASE DURANTE A GERMINAÇÃO DE Lactuca sativa L. EXPOSTA A METAIS PESADOS

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Anticonvulsant activity of Caryocar coriaceum Wittm. fixed pulp oil against pentylenetetrazol-induced seizures

Cited by 11 publications

References 30 publications

Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na+, K+-ATPase-Activating Antibody after Status Epilepticus

Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na+, K+-ATPase-Activating Antibody after Status Epilepticus

Caryocar coriaceum Wittm. (Caryocaraceae): Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, Extractivism and Conservation Needs

EXPRESSÃO DIFERENCIAL DA SUPERÓXIDO DISMUTASE E CATALASE DURANTE A GERMINAÇÃO DE Lactuca sativa L. EXPOSTA A METAIS PESADOS

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Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na⁺, K⁺-ATPase-Activating Antibody after Status Epilepticus

Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na⁺, K⁺-ATPase-Activating Antibody after Status Epilepticus