Anticonvulsant activity of Balanites aegyptiaca (L.) Del. Stem bark

Kasture, Sanjay; Gupta, Satish Chand; Kotecha, Mita

doi:10.1007/s13596-013-0135-1

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The HET root extract was devoid of any anticonvulsant activity in rodents [ 153 ] 7 Balanites aegyptica SB CH & HME PTZ, MES & PLC Male Albino Swiss mice (28–38 g) & male Albino Swiss rats (200–225 g) 200 & 400 Both solvent extracts significantly suppressed hind limb extension and delayed latency of myoclonic spasm and clonic convulsions of mice at all doses. Similarly, the CH (100 mg) and HME (100 & 200 mg) extracts delayed the latency to rearing with forelimb clonus in rats [ 154 ] 8 Buddleja polystachya L HME PTZ & MES S iss albino mice (27–33 gm) 100–400 The HME extract elicited a significant anticonvulsant effect in MES (all doses) and PTZ models (200 & 400 mg/kg). The BU fractions showed a significant anticonvulsant effect in both models.…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

“…Balanites aegyptiaca is used traditionally in Ethiopia, Mali, Saudi Arabia [ 116 , 117 ], and India to treat epilepsy. Hence, HMET and CHL extract of stembark of Balanites aegyptiaca were assessed using PTZ, MES-induced convulsions, and PLC-induced SE in rats [ 154 ]. Both the HME and CH extract at 200 and 400 mg/kg significantly delayed the onset of myoclonic spasm and clonic convulsions as well as significantly reduced the duration of hind limb extension in PTZ and MES models.…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

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Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Birhan

2022

Chin Med

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Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and a high incidence of mortalities. Antiepileptic drugs (AEDs) are the mainstream treatment options for the symptomatic relief of epilepsy. The incidence of refractory epilepsy and the dose-dependent neurotoxicity of AEDs such as fatigue, cognitive impairment, dizziness, attention-deficit behavior, and other side effects are the major bottlenecks in epilepsy treatment. In low- and middle-income countries (LMICs), epilepsy patients failed to adhere to the AEDs regimens and consider other options such as complementary and alternative medicines (CAMs) to relieve pain due to status epilepticus (SE). Plant-based CAMs are widely employed for the treatment of epilepsy across the globe including Ethiopia. The current review documented around 96 plant species (PS) that are often used for the treatment of epilepsy in Ethiopia. It also described the in vivo anticonvulsant activities and toxicity profiles of the antiepileptic medicinal plants (MPs). Moreover, the phytochemical constituents of MPs with profound anticonvulsant effects were also assessed. The result reiterated that a lot has to be done to show the association between herbal-based epilepsy treatment and in vivo pharmacological activities of MPs regarding their mechanism of action (MOA), toxicity profiles, and bioactive constituents so that they can advance into the clinics and serve as a treatment option for epilepsy.

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