Anticoagulation Therapy in Specific Cardiomyopathies: Isolated Left Ventricular Noncompaction and Peripartum Cardiomyopathy

Kido, Kazuhiko; Guglin, Maya

doi:10.1177/1074248418783745

Cited by 36 publications

(39 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, in our case, the child developed recurrent thrombosis despite anticoagulation therapy, while the mother received anticoagulation therapy only for a limited period, due to very decreased EF, without any thrombotic events in her evolution whatsoever. There are no specific guidelines regarding anticoagulation therapy in ILVNC; however, it is justified in the setting of associated systolic dysfunction/atrial fibrillation or thromboembolism history, including intracardiac thrombi ( 23 – 26 ).…”

Section: Discussionmentioning

confidence: 99%

Different Manifestations in Familial Isolated Left Ventricular Non-compaction: Two Case Reports and Literature Review

et al. 2020

View full text Add to dashboard Cite

Left ventricular non-compaction (LVNC) is a form of cardiomyopathy characterized by prominent trabeculae and deep intertrabecular recesses which form a distinct "non-compacted" layer in the myocardium. It results from intrauterine arrest of the compaction process of the left ventricular myocardium. Clinical manifestations vary from asymptomatic to heart failure (HF), arrhythmias, or thromboembolic events. We present a case of mother and son diagnosed with isolated LVNC (ILVNC). A 4years-old male patient, diagnosed at 3 months with ILVNC, and NYHA functional class IV HF, was admitted to the Emergency Institute for Cardiovascular Diseases and Transplantation of Targu Mures, Romania, for cardiologic reevaluation, and diagnosis confirmation. ILVNC was confirmed using echocardiography, revealing a non-compaction to compaction (NC/C) ratio of > 2.7. His evolution was stationary until the age of 8 years, when severe pneumonia caused hemodynamic decompensation, and he was listed for heart transplantation (HT). The patient underwent HT at the age of 11 years with favorable postoperative outcome. Meanwhile, a 22-years-old female patient, mother of the aforementioned patient, was also admitted to our institute due to severe fatigue, dyspnea, and recurrent palpitations with multiple implantable cardioverter defibrillator (ICD) shock delivery. Extensive medical history revealed that a presumptive ILVNC diagnosis was established when she was 11 years old. She was asymptomatic until 18 years old, when 3 months post-partum, she developed NYHA functional class III HF, and subsequently underwent ICD implantation. Her diagnosis was confirmed using multi-detector computed tomography angiography, which revealed a NC/C ratio of > 3.3. ICD adjustments were carried out with a favorable evolution under chronic drug therapy. The last evaluation, at 27 years old, revealed that she was in NYHA functional class II HF. In conclusion, ILVNC, even when familial, can present different clinical pictures and therefore requires different medical approaches.

show abstract

Section: Discussionmentioning

confidence: 99%

Different Manifestations in Familial Isolated Left Ventricular Non-compaction: Two Case Reports and Literature Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The incident rate of thromboembolism in LVNC is controversial (1,2,18). Anticoagulation with warfarin is recommended in LVNC patients with history of thromboembolism, atrial fibrillation, and/or a reduced LV function (LV ejection fraction <40%) (19). In addition, anticoagulation is indicated for thrombus in the LV as first-line therapy according to the JCS guideline (20).…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Noncompaction with Multiple Thrombi in Apical Aneurysm

et al. 2020

View full text Add to dashboard Cite

A 44-year-old man was admitted to our hospital due to heart failure. Transthoracic echocardiography demonstrated global hypokinesis with an ejection fraction of 25%, prominent trabeculation and deep intertrabecular recesses, and apical aneurysm with multiple thrombi (10×13 mm in the inferior wall, 15×8 mm in the anterior wall). Cardiac magnetic resonance imaging showed an increased ratio of noncompacted (NC) to compacted (C) myocardium (NC/C ratio >2.3) and apical aneurysm. Coronary angiography revealed no significant stenosis. He was therefore diagnosed with left ventricular noncompaction complicated by apical aneurysm. Four weeks after starting anticoagulation, the multiple apical thrombi disappeared without clinical signs of embolism.

show abstract

“…we did not sub-analyze intracardiac thrombi according to etiology (i.e., stress-induced cardiomyopathy, isolated left chamber noncompaction, peripartum cardiomyopathy, inflammatory bowel disease, Behcet Disease, leukemia) [9][10][11]. Moreover, as there was no significant correlation between thrombus location and ST, thrombi in the left atrium were not distinguished from those in the left ventricle.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for systemic thromboembolism after left chamber cardiac thrombi --- A retrospective multi-center study

zhou

Shi

et al. 2019

Preprint

View full text Add to dashboard Cite

Background : We aimed to characterize the independent predictors of systemic thromboembolism (ST) after left chamber thrombi. Methods: A retrospective analysis on the medical records of 175 patients diagnosed with left chamber thrombi by transthoracic echocardiography (TTE) at three centers were carried out. Multivariate logistic regression was performed to determine the relationship of each characteristic with ST. Multivariate Cox proportional survival analysis was conducted, with covariate adjustments, to identify predictors of all-cause mortality. Results: During a median 42 months of follow-up (25th–75th percentile: 20–62 months), 24 (13.7%) patients had ST, and 62 (35.4%) died. History of diabetes and thrombus mobility were independent predictors of ST (P = 0.003, P = 0.02, respectively). There was a significant association between abnormal ejection fraction (EF) and all-cause mortality (P = 0.003). Conclusions: The morbidity associated with ST and the increased risk for mortality associated with left chamber cardiac thrombi relates to medical history, thrombus state, and diminished heart function.

show abstract

Anticoagulation Therapy in Specific Cardiomyopathies: Isolated Left Ventricular Noncompaction and Peripartum Cardiomyopathy

Cited by 36 publications

References 42 publications

Different Manifestations in Familial Isolated Left Ventricular Non-compaction: Two Case Reports and Literature Review

Different Manifestations in Familial Isolated Left Ventricular Non-compaction: Two Case Reports and Literature Review

Left Ventricular Noncompaction with Multiple Thrombi in Apical Aneurysm

Risk factors for systemic thromboembolism after left chamber cardiac thrombi --- A retrospective multi-center study

Contact Info

Product

Resources

About