Anticoagulation-related intracranial extracerebral haemorrhage.

Mattle, Heinrich; Köhler, Steffen; Huber, Peter; Rohner, M; Steinsiepe, Klaus F.

doi:10.1136/jnnp.52.7.829

Cited by 93 publications

(47 citation statements)

References 21 publications

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“…The symptoms are relatively mild at onset in these patients. 3,6) The Glasgow Coma Scale score on admission was 2.1 points better in the bleeding tendency group compared with control group in the present series.…”

Section: Discussionsupporting

confidence: 50%

“…One study found anticoagulation-related acute subdural hematoma occurred in 25% of patients without trauma, 37.5% with minor trauma without loss of consciousness, 16.7% with cerebral concussion, and 16.7% with cerebral contusion. 6) The present study found that acute subdural hematoma without an accident or with over-turning occurred at a significantly higher rate among the bleeding tendency group (92%) compared with the control group (56.9%). Therefore, head CT should be performed proactively to check for intracranial hemorrhage even after minor head injury.…”

Section: Discussionmentioning

confidence: 64%

“…3,4,6) The PT-INR is related to the risk of the major hemorrhagic complications in the whole body. Major hemorrhagic complications often occur in patients with normal values (PT-INR 2.2 to 3.5) and the frequency (6.6% per year) is significantly higher than that in patients with low values (PT-INR 1.5 to 2.1; 0% per year).…”

Section: Discussionmentioning

confidence: 99%

“…4,6) Patients who develop acute subdural hematoma frequently have different clinical courses and worse outcome than unaffected patients. 3) This study reviewed 90 cases of acute subdural hematoma, including 25 cases with previous medication related to bleeding tendency, and discusses the clinical course, treatment, and outcome.…”

Section: Introductionmentioning

confidence: 99%

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Acute Subdural Hematoma in Patients With Medication Associated With Risk of Hemorrhage

Oyama

Kito

Maki

et al. 2011

Neurol. Med. Chir.(Tokyo)

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The characteristics of 90 cases of acute subdural hematoma were analyzed in 25 patients taking medication related to bleeding tendency, the bleeding tendency group, and 65 patients without such medication, the control group. Acute subdural hematoma was significantly associated with over-turning or without accident in the bleeding tendency group (92%) compared with the control group (56.9%). The time from trauma to admission was significantly longer in the bleeding tendency group (32.7 hours) compared with the control group (9.7 hours). The mean Glasgow Coma Scale score on admission was 13.0 points in the bleeding tendency group and was significantly better than 10.9 points in the control group. The international normalized ratio of prothrombin time on admission was 3.59 in the patients treated with warfarin. All patients taking warfarin received reversal agents and this value decreased significantly to 1.38. In the bleeding tendency group, hematoma size increased in 20% after the operation, almost the same as in the control group (25%). Although good recovery tended to be observed less frequently in the bleeding tendency group than in the control group, the mean age of the bleeding tendency group was significantly higher than that of the control group, so the prognosis might be affected by this age-related factor. Cautious diagnosis, follow-up imaging, and strict management are mandatory in patients with bleeding tendency.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute Subdural Hematoma in Patients With Medication Associated With Risk of Hemorrhage

Oyama

Kito

Maki

et al. 2011

Neurol. Med. Chir.(Tokyo)

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“…Bu bakımdan oral antikoagülan kullanan ve inme geçirmiş olgularda, özellikle de klinik belirtilerde ilerleme olduğunda vakit geçirilmeden tekrarlayan kontrol radyolojik incelemeler planlanmalıdır. Varfarin kullanan hastalarda hemorajik inme gelişme riski yıllık %1-1.5 oranlarında (2) değişmekte olup, kanamalar parankimal, subdural, epidural veya subaraknoid yerleşimli olabilir (2, [12][13][14][15]21,22). Kanama alanı lokalizasyonları, spontan intraserebral kanama ile benzerlik göstermektedir.…”

Section: Discussionunclassified

A case of warfarin associated intracerebral hemorrhage with delayed presentation of radiological findings

Aldemir¹,

Avsar²,

Çomoğlu³

2011

Türk Beyin Damar Hast Derg

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ÖZETİntraserebral kanama, antikoagulan tedavisinin en ciddi komplikasyonudur. Hastaların %50'sinde, kanama 12 ila 24 saat boyunca genişler ve antikoagulan etkinin en kısa zamanda geri çevrilmesi gerekir. Bu yazıda, mitral kapak replasmanı ve atrial fibrilasyon nedeniyle antikoagulan tedavi alırken inme geçiren, başlangıç radyolojik görüntülemesi normal olan, hastalık kliniğini açıklayabilecek radyolojik verilerin geç dönemde kontrol görüntülemede saptandığı, intraserebral hemoraji olgusunu sunuyoruz. Anahtar Sözcükler: İntraserebral kanama, varfarin, bilgisayarlı tomografi, nöroradyolojik bulgular A CASE OF WARFARIN ASSOCIATED INTRACEREBRAL HEMORRHAGE WITH DELAYED PRESENTATION OF RADIOLOGICAL FINDINGS SUMMARY Intracerebral hemorrhage (ICH) is the most serious complication of oral anticoagulant therapy (OAT). In approximately half of anticoagulated patients with intracerebral hematoma, the bleeding evolves slowly over 12 to 24 hours, and emergency reversal of anticoagulation is necessary. In this article we represent a case of intracerebral hemorrhage while having anticoagulant medication as a treatment of mitral valve replacement and atrial fibrillation whose explationary radiological findings exploited in latter controls despite having initially normal radiological screens.

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Choosing Antithrombotic Therapy for Elderly Patients With Atrial Fibrillation Who Are at Risk for Falls

Man-Son-Hing

Nichol²,

Lau³

et al. 1999

Arch Intern Med

466

238

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Objective: To determine whether the risk of falling (with a possible increased chance of subdural hematoma) should influence the choice of antithrombotic therapy in elderly patients with atrial fibrillation.Design: A Markov decision analytic model was used to determine the preferred treatment strategy (no antithrombotic therapy, long-term aspirin use, or longterm warfarin use) for patients with atrial fibrillation who are 65 years of age and older, are at risk for falling, and have no other contraindications to antithrombotic therapy. Input data were obtained by systematic review of MED-LINE. Outcomes were expressed as quality-adjusted lifeyears.

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Anticoagulation-related intracranial extracerebral haemorrhage.

Cited by 93 publications

References 21 publications

Acute Subdural Hematoma in Patients With Medication Associated With Risk of Hemorrhage

Acute Subdural Hematoma in Patients With Medication Associated With Risk of Hemorrhage

A case of warfarin associated intracerebral hemorrhage with delayed presentation of radiological findings

Choosing Antithrombotic Therapy for Elderly Patients With Atrial Fibrillation Who Are at Risk for Falls

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