Anticoagulation control of pharmacist-managed collaborative care versus usual care in Thailand

Saokaew, Surasak; Sapoo, Ubonwan; Nathisuwan, Surakit; Chaiyakunapruk, Nathorn; Permsuwan, Unchalee

doi:10.1007/s11096-011-9597-8

Cited by 44 publications

(43 citation statements)

References 28 publications

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“…Whereas, Witt et al study that included 6645 patients reported significant higher TTR in clinical pharmacy anticoagulation service group compared with usual care (63.5% vs 55.2%, p<0.001) which was other from RCTs pooled results in our study (12). The similar results reported in several studies that time in the INR therapeutic range was 48.1%~78.5% in pharmacist management group while 4.01%~66.2% of other management models (27,28,32,41,42,44,45). Most of opposite results came from retrospective chart review studies and our results from RCTs grading as moderate quality evidence were more convictive.…”

Section: Discussionsupporting

confidence: 78%

“…A couple of studies indicated that the percentage of time within the expanded therapeutic range of patients in pharmacist-led management group were significantly higher than of control group (26,41,42), which was up to 90.8% in pharmacist management group from Young et al study (90.8% vs 84.8%, p<0.0001) (32). Although, no publication bias and serious heterogeneity were detected in RCTs and observational studies of INR control, inadequate studies and sample size arrived at poor results.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of Pharmacist-led Anticoagulation Management on Clinical Outcomes: A Systematic Review and Meta-Analysis

Hou

Yang

et al. 2017

J Pharm Pharm Sci

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-OBJECTIVES:We performed this systematic review and meta-analysis to confirm whether patients benefit more from pharmacist-led anticoagulation management than other models. METHODS: We searched PubMed, Embase, Cochrane Library and reference lists of yielded results conducted up to April 25, 2017. RCTs and observational cohort studies and case-control studies which compared the percentage of time within the target therapeutic range (TTR), the percentage of time within the expanded therapeutic range (TER), haemorrhage events, thrombosis events, mortality, patient satisfaction and/or medicine cost saving of pharmacist-led anticoagulation management with other models, and species were limited to humans. Two investigators evaluated methodology and extracted data from included studies independently. Data analysis were performed by STATA 12.0 software and quality of evidence assessment was performed by GRADEprofiler software. RESULTS: 8 RCTs and 9 observational cohort studies with 9919 patients were included eventually with high quality and no publication bias. In RCTs pooled results, TTR (p=0.548 moderate-quality), TER (p=0.285, moderate-quality), total haemorrhage events (p=0.140, low-quality), minor haemorrhage events (p=0.162, low-quality), major haemorrhage events (p=0.237, low-quality), thrombosis events (p=0.615, low-quality) and mortality (p=0.876, low-quality) was not significant between two groups.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Effectiveness of Pharmacist-led Anticoagulation Management on Clinical Outcomes: A Systematic Review and Meta-Analysis

Hou

Yang

et al. 2017

J Pharm Pharm Sci

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“…28 Our TTR values were also similar to studies developed in other tertiary hospitals (from 53.9% to 65.1%). [29][30][31] INR/current dose ratio was also significantly higher in the group of patients taking amiodarone compared with patients who did not take amiodarone. This ratio is a simple and logical way of expressing the variability of INR response to the different warfarin doses according to amiodarone use.…”

Section: Tablementioning

confidence: 82%

Simultaneous Use of Amiodarone Influences Warfarin Maintenance Dose but Is Not Associated with Adverse Events

Santos¹,

Soares

Strunz³

et al. 2014

JMCP

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“…We planned a study using continuous response variables from independent usual care and intervention subjects with one instance of usual care per intervention subject. In a previous study (12), the response within each group was normally distributed with standard deviation (SD) of 8.5. If the true difference between the intervention and usual care means is 8.2, we would require 18 subjects per group to be able to reject the null hypothesis that the population means of the Intervention and Usual care groups are equal with probability (i.e., power) of 0.8.…”

Section: Sample Size Calculationmentioning

confidence: 99%

Hospital pharmacist intervention improves the quality indicator of warfarin control: A retrospective cohort study

Kose

Kikkawa

et al. 2017

J. Med. Invest.

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Background/Aims Our previous study showed that time in therapeutic range (TTR) control of warfarin therapy was negatively affected in non -valvular atrial fibrillation (NVAF) patients with heart failure. This study assesses the effect of intervention byhospital pharmacists on TTR control in Japanese NVAF patients with heart failure. Method This retrospective cohort study included NVAF patients with heart failure admitted and discharged from the cardiovascular internal medicine ward between March 2011 and July 2013. Participants were classified into two groups according to the instructions by hospital pharmacists and physicians (Intervention group) and by physicians only (Usual care group). The primary outcome was TTR. Secondary outcomes were major bleeding and minor bleeding. Results In total, 57 participants (35 males, 22 females ; mean age : 69.7 years) were classified into the Intervention (n = 25) and Usual care (n = 32) groups. TTR within-therapeutic range was significantly higher and within sub-therapeutic range was significantly lower in the Intervention than the Usual care group. Major bleeding and minor bleeding were not significantly different between the two groups. Conclusion The intervention of hospital pharmacists with anticoagulation therapy can lead to proper use of warfarin, which can be useful when physicians prescribe warfarin.

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Anticoagulation control of pharmacist-managed collaborative care versus usual care in Thailand

Cited by 44 publications

References 28 publications

Effectiveness of Pharmacist-led Anticoagulation Management on Clinical Outcomes: A Systematic Review and Meta-Analysis

Effectiveness of Pharmacist-led Anticoagulation Management on Clinical Outcomes: A Systematic Review and Meta-Analysis

Simultaneous Use of Amiodarone Influences Warfarin Maintenance Dose but Is Not Associated with Adverse Events

Hospital pharmacist intervention improves the quality indicator of warfarin control: A retrospective cohort study

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