Anticoagulation Control in Patients With Nonvalvular Atrial Fibrillation Attended at Primary Care Centers in Spain: The PAULA Study

Barrios, Vivencio; Escobar, Carlos; Prieto, Luís; Osorio, Genoveva; Polo, José Polo; Lobos, José María; Vargas, Diana; García, Nicolás

doi:10.1016/j.rec.2015.04.017

Cited by 39 publications

(70 citation statements)

References 31 publications

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“…Also, several studies 19,[30][31][32][33] showed that 40%-54% of anticoagulated patients with VKAs in our country had a low quality of anticoagulation with a TTR of <65% estimated by Rosendaal. Also, several studies 19,[30][31][32][33] showed that 40%-54% of anticoagulated patients with VKAs in our country had a low quality of anticoagulation with a TTR of <65% estimated by Rosendaal.…”

Section: Discussionmentioning

confidence: 87%

Relation of quality of anticoagulation control with different management systems among patients with atrial fibrillation: Data from FANTASIIA Registry

Rabadán

Esteve-Pastor

Anguita‐Sánchez

et al. 2018

Eur J Clin Investigation

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Section: Discussionmentioning

confidence: 87%

Relation of quality of anticoagulation control with different management systems among patients with atrial fibrillation: Data from FANTASIIA Registry

Rabadán

Esteve-Pastor

Anguita‐Sánchez

et al. 2018

Eur J Clin Investigation

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“…Of the 1524 patients included in the PAULA study, data were available in 1381 patients, allowing calculation of the eGFR (Figure ). The average eGFR was 73.32±22.9 mL/min/1.73 m 2 and 26.8% (n=370) of patients had CKD (eFGR <60 mL/min/1.73 m 2 ).…”

Section: Resultsmentioning

confidence: 98%

“…Informed consent from participants was obtained. The methodology and main results have been previously published …”

Section: Methodsmentioning

confidence: 99%

“…The study involved 139 primary care physicians from 99 healthcare centers across Spain. The main criteria for patient inclusion have been reported . For this study, we included only those PAULA patients who had at least one recent creatinine blood test available (<6 months old), as well as the TTR data.…”

Section: Methodsmentioning

confidence: 99%

“…Because CKD is linked to other factors such as advanced age, diabetes mellitus, uncontrolled hypertension and cardiovascular disease, the information available about the true impact of CKD on the control of TTR is limited. 10,12 In a sub-analysis of the PAULA study, 18,19 we reported the discriminative ability of the SAMe-TT 2 R 2 score and three additional factors as predictors of a TTR <65% were identified: dietary pattern, risk of bleeding and polypharmacy. Although CKD was included in comorbidities from the data obtained from the subjects' medical history, this carried a relatively low weight on the predictive value of the SAMe-TT 2 R 2 score, as clinical records may underestimate CKD in comparison to an ad hoc estimate of renal function employing the appropriate equations.…”

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confidence: 99%

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Influence of renal function on anticoagulation control in patients with non-valvular atrial fibrillation taking vitamin K antagonists

Lobos-Bejarano¹,

Rodríguez

Barrios

et al. 2017

Int J Clin Pract

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Summary Background and Purpose Chronic kidney disease (CKD) has been related to poor anticoagulation control and an increased risk of bleeding. This study aims to evaluate the association between impaired renal function (eGFR <60 mL/min/1.73 m2) and anticoagulation control in patients with non‐valvular atrial fibrillation (AF) on vitamin K antagonists (VKA) therapy. We also assessed whether the predictive value of the SAMe‐TT2R2 score prevailed for subgroups both with and without CKD. Methods This is an ancillary analysis of 1381 patients from the PAULA study, which was a cross‐sectional, retrospective and nationwide multicenter study. Results A total of 370 patients had eGFR <60 mL/min/1.73 m2. Anticoagulation control levels progressively worsened across each stage of CKD. Multiple linear regression analysis showed CKD as an independent predictor of time in therapeutic range (TTR). In the subgroup of patients with preserved renal function, female sex, diet affecting INR, polypharmacy and amiodarone were associated with poorer TTR. The SAMe‐TT2R2 score had a significant but modest predictive value for TTR<65% (AUC, area under the curve 0.558, P = .002). In the subgroup of patients with CKD, the SAMe‐TT2R2 (>2 points) showed no significant predictive capacity for TTR (AUC 0.528, P = .354). The average TTR was similar for both sexes (P = .255), but with a higher percentage of males subjects with TTR ≥65% (P = .013). Conclusion Chronic kidney disease is associated with poor anticoagulation control in patients with non‐valvular AF taking VKA. The SAMe‐TT2R2 score was not predictive of poor TTR in the subgroup with CKD, although a modest predictive value for poor TTR was found in those without CKD.

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Safety and efficacy of new oral anticoagulants compared to those of warfarin in AF patients with cancer: a meta-analysis of randomized clinical trials and observational studies

Chen

Mao

Chang

et al. 2021

Eur J Clin Pharmacol

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Anticoagulation Control in Patients With Nonvalvular Atrial Fibrillation Attended at Primary Care Centers in Spain: The PAULA Study

Cited by 39 publications

References 31 publications

Relation of quality of anticoagulation control with different management systems among patients with atrial fibrillation: Data from FANTASIIA Registry

Relation of quality of anticoagulation control with different management systems among patients with atrial fibrillation: Data from FANTASIIA Registry

Influence of renal function on anticoagulation control in patients with non-valvular atrial fibrillation taking vitamin K antagonists

Safety and efficacy of new oral anticoagulants compared to those of warfarin in AF patients with cancer: a meta-analysis of randomized clinical trials and observational studies

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