Anticoagulant properties of a fucoidan fraction

Colliec, S.; Fischer, Anne‐Marie; Tapon‐Bretaudière, Jacqueline; Boisson, Christophe; Durand, Patrick; Jozefonvicz, J.

doi:10.1016/0049-3848(91)90114-c

Cited by 163 publications

(75 citation statements)

References 18 publications

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“…However, these compounds have several side effects such as bleeding and thrombocytopenia (2,3). In addition, the commercial sources of heparins are mainly pig and bovine intestine.…”

mentioning

confidence: 99%

Structural and Hemostatic Activities of a Sulfated Galactofucan from the Brown Alga Spatoglossum schroederi

Rocha

Moraes

Trindade

et al. 2005

Journal of Biological Chemistry

142

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The brown alga Spatoglossum schroederi contains three fractions of sulfated polysaccharides. One of them was purified by acetone fractionation, ion exchange, and molecular sieving chromatography. It has a molecular size of 21.5 kDa and contains fucose, xylose, galactose, and sulfate in a molar ratio of 1.0:0.5:2.0:2.0 and contains trace amounts of glucuronic acid. Chemical analyses, methylation studies, and NMR spectroscopy showed that the polysaccharide has a unique structure, composed of a central core formed mainly by 4-linked ␤-galactose units, partially sulfated at the 3-O position. Approximately 25% of these units contain branches of oligosaccharides (mostly tetrasaccharides) composed of 3-sulfated, 4-linked ␣-fucose and one or two nonsulfated, 4-linked ␤-xylose units at the reducing and nonreducing end, respectively. This sulfated galactofucan showed no anticoagulant activity on several "in vitro" assays. Nevertheless, it had a potent antithrombotic activity on an animal model of experimental venous thrombosis. This effect is time-dependent, reaching the maximum 8 h after its administration compared with the more transient action of heparin. The effect was not observed with the desulfated molecule. Furthermore, the sulfated galactofucan was 2-fold more potent than heparin in stimulating the synthesis of an antithrombotic heparan sulfate by endothelial cells. Again, this action was also abolished by desulfation of the polysaccharide. Because this sulfated galactofucan has no anticoagulant activity but strongly stimulates the synthesis of heparan sulfate by endothelial cells, we suggested that this last effect may be related to the "in vivo" antithrombotic activity of this polysaccharide. In this case the highly sulfated heparan sulfate produced by the endothelial cells is in fact the antithrombotic agent. Our results suggested that this sulfated galactofucan may have a potential application as an antithrombotic drug.

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“…However, these compounds have several side effects such as bleeding and thrombocytopenia (2,3). In addition, the commercial sources of heparins are mainly pig and bovine intestine.…”

mentioning

confidence: 99%

Structural and Hemostatic Activities of a Sulfated Galactofucan from the Brown Alga Spatoglossum schroederi

Rocha

Moraes

Trindade

et al. 2005

Journal of Biological Chemistry

142

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“…3,5,6) However, only a few studies on the polysaccharides from plants have been reported regarding antithrombotic activity. 20) In the present study, we isolated two sulfated polysaccharides with a comparable antithrombotic activity from Syzygium aromaticum (L.) MERR.…”

Section: Discussionmentioning

confidence: 99%

“…5) So far, the studies for the potential antithrombotics from natural sources have focused mostly on mammalian tissues and seaweeds. 6) Recently, pharmaceutical function to certain ailments in edible plants has received an increasing attention.…”

mentioning

confidence: 99%

Purification and Characterization of Antithrombotics from Syzygium aromaticum (L.) MERR. & PERRY.

Lee

Jun

et al. 2001

Biological & Pharmaceutical Bulletin

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“…Fucoidan have in vivo and in vitro heparin like activity that show anti thrombic and anti-coagulant activity, which are mediated by blood coagulation inhibitors such as heparin cofactor II or anti-thrombin III [91] [92]. When fucan and thrombin interact with each other directly than anti-coagulant activity is produce in result and it usually increase with the amount sulphation [93]- [95].…”

Section: Anti-thrombic and Anti-coagulant Activitymentioning

confidence: 99%

Bioactive Compounds and Properties of Seaweeds—A Review

Pal¹,

Kamthania²,

Kumar³

2014

OALib

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In last three decades the discovery of metabolite and biological activities from macroalgae has been increased significantly. Many sophisticated modern research tools are available for making of chemical compound but there are still many natural bioactive compounds in the womb of nature which is a mystery, scientist are still working to find out more biologically active compounds. Bioactive substances from seaweeds currently receive the more attention from the pharmaceutical companies for the drug development as well as the researchers. Seaweeds are taking majority of attention from scientists because of its phenomenon bioactive compounds and its properties like anti-viral, anti-tumor, anti-inflammatory and anti-lipedimic and may more properties. This current review described mainly substances like metabolite, properties, and types of seaweeds. Emphasis is given to main metabolite and properties of seaweeds.

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Anticoagulant properties of a fucoidan fraction

Cited by 163 publications

References 18 publications

Structural and Hemostatic Activities of a Sulfated Galactofucan from the Brown Alga Spatoglossum schroederi

Structural and Hemostatic Activities of a Sulfated Galactofucan from the Brown Alga Spatoglossum schroederi

Purification and Characterization of Antithrombotics from Syzygium aromaticum (L.) MERR. & PERRY.

Bioactive Compounds and Properties of Seaweeds—A Review

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