Anticoagulant properties of a crude sulfated polysaccharide from the red marine alga Halymenia floresia (Clemente) C. Agardh

Amorim, Rodrigo César das Neves; Rodrigues, José Ariévilo Gurgel; Araújo, Márjory Lima Holanda; Mourão, Paulo Antônio de Souza; Benevídes, Norma Maria Barros

doi:10.4025/actascibiolsci.v33i3.6402

Cited by 13 publications

(2 citation statements)

References 29 publications

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“…Results showed a reduction and inhibition of thrombin and factor X in blood coagulation, making Solieria filiformis a good candidate for the development of anticoagulant natural drugs [173]. Although seaweeds extracts are not potent as heparin, other studies confirm the anticoagulant potential of carrageenans [228][229][230][231].…”

Section: Phylum Rhodophytamentioning

confidence: 99%

An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

Lomartire

Gonçalves

2022

Marine Drugs

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Nowadays, seaweeds are widely involved in biotechnological applications. Due to the variety of bioactive compounds in their composition, species of phylum Ochrophyta, class Phaeophyceae, phylum Rhodophyta and Chlorophyta are valuable for the food, cosmetic, pharmaceutical and nutraceutical industries. Seaweeds have been consumed as whole food since ancient times and used to treat several diseases, even though the mechanisms of action were unknown. During the last decades, research has demonstrated that those unique compounds express beneficial properties for human health. Each compound has peculiar properties (e.g., antioxidant, antimicrobial, antiviral activities, etc.) that can be exploited to enhance human health. Seaweed’s extracted polysaccharides are already involved in the pharmaceutical industry, with the aim of replacing synthetic compounds with components of natural origin. This review aims at a better understanding of the recent uses of algae in drug development, with the scope of replacing synthetic compounds and the multiple biotechnological applications that make up seaweed’s potential in industrial companies. Further research is needed to better understand the mechanisms of action of seaweed’s compounds and to embrace the use of seaweeds in pharmaceutical companies and other applications, with the final scope being to produce sustainable and healthier products.

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Section: Phylum Rhodophytamentioning

confidence: 99%

An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

Lomartire

Gonçalves

2022

Marine Drugs

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“…Over the last decade, red and brown algae have attracted much interest in the search of anti-HIV action and fewer reports are found for green algae (Vlietinck et al, 2008, Rodrigues et al, 2009Yasuhara-Bell and Lu, 2010;Mattos et al, 2011). The antiviral activity described in the present study can be attributed to bioactive polar compounds that are methanolic-and water-soluble.…”

Section: Discussionmentioning

confidence: 55%

Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Harb¹

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A wide variety of metabolites extracted from macroalgae is currently used as functional food ingredients, natural nutraceuticals, biomedical materials, cosmetic formulations, as well as in other products that promote human health. One of the major limitations in the search for new extracts or natural products with biological action is the lack of available biomass for studies and even for their bioprospection. In this context, the availability of beach-cast marine algae is a sustainable and highly productive alternative. The main objective of this study was to evaluate the chemical and bioactive potential of extracts from 15 materials of beach-cast marine algae collected from the Brazilian coast to provide subsidies that allow identifying the potentialities and its uses as functional product. The findings showed that the highest antioxidant activities were found in extracts from brown beach-cast algae followed by the extracts of red beach-cast algae, and the lowest activities were detected in the green beach-cast species. The most efficient extracts of beach-cast species with antioxidant properties were from Dictyopteris jolyana, Zonaria tournefortii, and Osmundaria obtusiloba. Regarding antiviral activity, the aqueous extract of Codium isthmocladum and methanolic extracts from D. jolyana, Z. tournefortii Alsidium seaforthii, Spiridia clavata and O. obtusiloba were highly promising, reaching inhibition percentage above 90%. The extracts of Z. tournefortii, A, seaforthii and C. isthmocladum showed high cytotoxicity activity against the tumoral cells strains HL60 (leukemia) and HTC116 (colon) and did not show any cytotoxicity activity against non-tumoral human cells (HGF1). Currently, the large amount of beach-cast seaweeds deposited on the beaches of Brazil is collected and treated as trash, being incinerated or disposed in landfills by the government. Instead of using public resources and making efforts for the removal of this biomass, it is possible to propose different uses for the Brazilian beach-cast seaweeds and transform it into applications for several sectors. Due to the antioxidant, antiviral, nutritional, photoprotective and cytotoxic properties reported for macroalgae, such applied features bring environmental benefits by mitigating coastal pollution generating a usable resource, in addition to ensuring sustainable social and economic development. The review data shown in the literature of Brazilian beach-cast algae shows the relevance and innovation of this study. This is the first report evaluating chemical composition, antioxidant potential, antiviral activity, cytotoxicity potential and photoprotection of extracts from beach-cast algae from the Brazilian coast. The potential of beach-cast seaweeds provides raw-material for several applications, combined with the large amount available on the beaches of certain regions at the Brazilian coast can be better exploited. The present study significantly contributes to increasing knowledge of Brazilian beach-cast algae and their potential uses as well as t...

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Assessment of the in Vitro Antimelanoma Potential of Lippia microphylla Cham (Verbenaceae) Essential Oil

de Oliveira Lopes,

Neves de Andrade,

Sousa Duarte

et al. 2023

Chemistry & Biodiversity

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Essential oils stand out among natural products for their complex composition, frequently described in the literature with a range of biological effects. This study evaluated the cytotoxic activity against several human cancer cell lines of essential oils extracted from the leaves of Lippia microphylla (EO‐LM) Cham. (Verbenaceae). The melanoma cell line SK‐MEL‐28 was the most sensitive to the EO‐LM, presenting an IC50 of 33.38 ± 1.16 µg/mL. Afterward, the effects of EO‐LM on the cell cycle, induction of apoptosis, and production of reactive oxygen species (ROS) were evaluated. We stated a significant increase in the sub‐G1 population, indicating apoptosis, later confirmed by an increase of SK‐MEL‐28 cells labeled with Annexin V‐FITC and by the formation of apoptotic bodies and membrane blebs, observed by confocal microscopy. Additionally, EO‐LM reduced the production of ROS, indicating antioxidant activity. Therefore, EO‐LM exhibits anti‐melanoma activity in vitro, suggesting its potential as an anticancer agent.

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Anticoagulant properties of a crude sulfated polysaccharide from the red marine alga Halymenia floresia (Clemente) C. Agardh

Cited by 13 publications

References 29 publications

An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Assessment of the in Vitro Antimelanoma Potential of Lippia microphylla Cham (Verbenaceae) Essential Oil

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