Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus

Ohaeri, O. C.; Adoga, Godwin I.

doi:10.1007/s10540-006-9004-1

Cited by 22 publications

(16 citation statements)

References 17 publications

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“…Garlic has long been known for its beneficial effects on cardiovascular disease and its associated risk factors, such as dyslipidemia, hypercholesterolemia, hypertension, and anticoagulant disorders, which were broadly reviewed elsewhere [53,54]. It has also been shown in alloxan-DM or STZ-DM animal models that, regardless of whether FBS improved significantly, treatment with garlic can normalize elevated serum triglyceride and cholesterol concentrations [33,43], improve abnormalities in vascular reactivity [35,36], and in platelet coagulation [55]. In addition, it has been reported in an STZ-DM model that garlic extracts can improve deficiencies in aortic and cardiac output, thickening of the left ventricular wall, and complications with the intramural coronary arteries associated with DM [38].…”

Section: Effect Of Garlic On Complications Of Diabetes Mellitusmentioning

confidence: 99%

Does garlic have a role as an antidiabetic agent?

Liu

Sheen

Lii

2007

Molecular Nutrition Food Res

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Diabetes affects a large segment of the population worldwide, and the prevalence of this disease is rapidly increasing. Despite the availability of medication for diabetes, traditional remedies are desirable and are currently being investigated. Garlic (Allium sativum), which is a common cooking spice and has a long history as a folk remedy, has been reported to have antidiabetic activity. However, there is no general agreement on the use of garlic for antidiabetic purposes, primarily because of a lack of scientific evidence from human studies and inconsistent data from animal studies. The validity of data from previous studies of the hypoglycemic effect of garlic in diabetic animals and the preventive effects of garlic on diabetes complications are discussed in this review. The role of garlic as both an insulin secretagogue and as an insulin sensitizer is reviewed. Evidence suggests that garlic's antioxidative, antiinflammatory, and antiglycative properties are responsible for garlic's role in preventing diabetes progression and the development of diabetes-related complications. Large-scale clinical studies with diabetic patients are warranted to confirm the usefulness of garlic in the treatment and prevention of diabetes.

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Section: Effect Of Garlic On Complications Of Diabetes Mellitusmentioning

confidence: 99%

Does garlic have a role as an antidiabetic agent?

Liu

Sheen

Lii

2007

Molecular Nutrition Food Res

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“…Garlic compounds have been shown to have antiviral, antibacterial, antioxidant, anti-inflammatory, antiproliferative, and antiangiogenic activities [14–19]. In vitro and in vivo preclinical studies have implicated DATS as an important mediator of cyclins and cell cycle arrest, apoptosis, cell adhesion, and angiogenesis [20–27].…”

Section: Introductionmentioning

confidence: 99%

Reversion of P-Glycoprotein-Mediated Multidrug Resistance in Human Leukemic Cell Line by Diallyl Trisulfide

Xia

Wang

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Multidrug resistance (MDR) is the major obstacle in chemotherapy, which involves multiple signaling pathways. Diallyl trisulfide (DATS) is the main sulfuric compound in garlic. In the present study, we aimed to explore whether DATS could overcome P-glycoprotein-(P-gp-)mediated MDR in K562/A02 cells, and to investigate whether NF-κB suppression is involved in DATS-induced reversal of MDR. MTT assay revealed that cotreatment with DATS increased the response of K562/A02 cells to adriamycin (the resistance reversal fold was 3.79) without toxic side effects. DATS could enhance the intracellular concentration of adriamycin by inhibiting the function and expression of P-gp, as shown by flow cytometry, RT-PCR, and western blot. In addition, DATS resulted in more K562/A02 cell apoptosis, accompanied by increased expression of caspase-3. The expression of NF-κB/p65 (downregulation) was significantly linked to the drug-resistance mechanism of DATS, whereas the expression of IκBα was not affected by DATS. Our findings demonstrated that DATS can serve as a novel, nontoxic modulator of MDR, and can reverse the MDR of K562/A02 cells in vitro by increasing intracellular adriamycin concentration and inducing apoptosis. More importantly, we proved for the first time that the suppression of NF-κB possibly involves the molecular mechanism in the course of reversion by DATS.

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“…This is also reported by JensenJarolim et al (1998). Furthermore, tomatoes, turmeric and ginger were known for their anticancer properties as reported by Ohaeri and Adoga (2006) and Mann (2011). These spices have different methods of preparations.Thus, besides the culinary significance of Hausa spices they played a great therapeutic role in Hausa traditional pharmacopoeia.…”

Section: Resultsmentioning

confidence: 95%

Ethnomedicinal study of some plants used as spices by the inhabitants of Kano Metropolis, northern Nigeria

Negbenebor¹,

Mairami²,

Salisu³

2018

Bayero J. Pure App. Sci.

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A research was conducted to study the ethnomedicinal importance of some plants used as spices by the indigenous people of selected markets in the area. A self collection. The result obtained revealed the presence of fourteen different plant species representing nine families used as spices. These spices were found to be very effective against several clinical symptoms such as rheumatism, pneumonia, stomachache, fever, pile and ulcerative colitis among others. They also served as hypolipidemic, antithrombotic, anti hypertensive, anti-hyperglycemic, antihypercholesterolemic and immuno as anticancer agents. Garlic, clove, ginger, nutmeg and chilli pepper are the most predominant spices used in the area with relative frequent use of 25%, 24%, 21%, 15% and 9% respectively. The research also discovered their methods of preparation to vary from one location to another within the area. However, despite the roles they play in adding taste and flavor and nutritional composition to the diets, their usage is declinin changing pattern of food choice and urbanization coupled with economic melt therefore the need to call the attention of the health care sector to review the medicinal value of the spices and involve their applications into

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Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus

Cited by 22 publications

References 17 publications

Does garlic have a role as an antidiabetic agent?

Does garlic have a role as an antidiabetic agent?

Reversion of P-Glycoprotein-Mediated Multidrug Resistance in Human Leukemic Cell Line by Diallyl Trisulfide

Ethnomedicinal study of some plants used as spices by the inhabitants of Kano Metropolis, northern Nigeria

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