Anticoagulant and antithrombotic actions of a semisynthetic β-1,3-glucan sulfate

Alban, Susanne; Jeske, Walter; Welzel, D; Franz, Gerhard; Fareed, Jawed

doi:10.1016/0049-3848(95)00049-w

Cited by 42 publications

(20 citation statements)

References 11 publications

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“…The antithrombotic effect of GGM-SO 4 was less, in terms of weight than heparin, which completely prevent thrombosis at a dose of 0.1 mg kg −1 body weight. When other sulfated polysaccharides were compared with GGM-SO 4 , we observed that a chemically sulfated (1 → 3)-linked ␤-glucan completely inhibited thrombus formation, but only at a concentration 20 times greater than that of unfractionated heparin [21], and a fucosylated chondroitin sulfate completely inhibited thrombus formation at a dose of 1.5 mg kg −1 body weight, 25 times greater than unfractionated heparin used.…”

Section: Discussionmentioning

confidence: 89%

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Anticoagulant and antithrombotic activities of a chemically sulfated galactoglucomannan obtained from the lichen Cladonia ibitipocae

Martinichen-Herrero

Carbonero

Sassaki

et al. 2005

International Journal of Biological Macromolecules

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Section: Discussionmentioning

confidence: 89%

“…Studies on a number of other sulfated polysaccharides, obtained by sulfation of natural polysaccharide and those occurring naturally, have been carried out related to in vivo and in vitro anticoagulant and antithrombotic properties with the aim of finding substitutes for heparin [3,[19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Anticoagulant and antithrombotic activities of a chemically sulfated galactoglucomannan obtained from the lichen Cladonia ibitipocae

Martinichen-Herrero

Carbonero

Sassaki

et al. 2005

International Journal of Biological Macromolecules

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“…151 Although anti-coagulant activity could be introduced in these neutral polymers, the activity was small and the possibilities of enhancing it further are less. Similarly, neutral carbohydrate polymers including chitosan, 152,153 dextran, [154][155][156][157] galactomannan, 158 and fucan, 159,160 have been sulfated, yet the anticoagulant activity level in each of these polymers is small. …”

Section: S Y N T H E T I C M O D I F I E D H E P a R I N S A N D H mentioning

confidence: 98%

New antithrombin‐based anticoagulants

Desai

2003

Medicinal Research Reviews

131

115

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Clinically used anticoagulants are inhibitors of enzymes involved in the coagulation pathway, primarily thrombin and factor Xa. These agents can be either direct or indirect inhibitors of clotting enzymes. Heparin-based anticoagulants are indirect inhibitors that enhance the proteinase inhibitory activity of a natural anticoagulant, antithrombin. Despite its phenomenal success, current anticoagulation therapy suffers from the risk of serious bleeding. The need for safer and more effective antithrombotic agents clearly exists. The past decade has seen enormous effort directed toward discovering and/or designing new molecules with anticoagulant activity. These new molecules can be classified into (a). antithrombin and its mutants, (b). natural polysaccharides, (c). synthetic modified heparins and heparin-mimics, (d). synthetic oligosaccharides, and (e). synthetic non-sugar antithrombin activators. This review focuses on these efforts in designing or discovering new molecules that act through the antithrombin pathway of anticoagulation.

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“…The anticoagulant glycosaminoglycan heparin is an important therapeutic agent for prophylaxis and treatment of thrombosis (17); dermatan sulfate is also anticoagulant, although of lower potency than heparin (18,19). Other sulfated polysaccharides, either extracted from marine brown (16, 20 -23) and red alga (24,25), or obtained by chemical sulfation of natural polysaccharides (26), have been described as anticoagulant. In contrast with heparin and dermatan sulfate, the structural components of these algal sulfated polysaccharides have not been characterized for anticoagulant activity.…”

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confidence: 99%

Structure and Anticoagulant Activity of Sulfated Galactans

Farias

Valente

Pereira

et al. 2000

Journal of Biological Chemistry

261

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We have characterized the structure of a sulfated Dgalactan from the red algae Botryocladia occidentalis. Possibly, the addition of two sulfate esters to a single ␣-galactose residue has an "amplifying effect" on the anticoagulant action, which cannot be totally ascribed to the increased charge density of the polymer. These results indicate that the wide diversity of polysaccharides from marine alga and invertebrates is a useful tool to elucidate structure/anticoagulant activity relationships.

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Anticoagulant and antithrombotic actions of a semisynthetic β-1,3-glucan sulfate

Cited by 42 publications

References 11 publications

Anticoagulant and antithrombotic activities of a chemically sulfated galactoglucomannan obtained from the lichen Cladonia ibitipocae

Anticoagulant and antithrombotic activities of a chemically sulfated galactoglucomannan obtained from the lichen Cladonia ibitipocae

New antithrombin‐based anticoagulants

Structure and Anticoagulant Activity of Sulfated Galactans

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