Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms

Oliveira, Clayton Z.; Maiorano, Victor A.; Marcussi, Silvana; Sant’Ana, Carolina D.; Januário, Ana Helena; Lourenço, Miriam Vergínia; Sampaio, Suely Vilela; França, Suzelei C.; Pereira, Paulo Sérgio; Soares, Andreimar M.

doi:10.1016/j.jep.2004.12.028

Cited by 78 publications

(59 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, an in vitro antitumoral activity was described and related to an unusual nitrogenated compound isolated from the leaves (Lim et al, 2006), while Oliveira et al (2005) showed that the aqueous extract from aerial parts of B. forficata was able to neutralize the clotting activity induced by Bothrops and Crotalus crude venoms. This study concluded that the plant extract is also a promising source of natural inhibitors of serine-proteases involved in blood clotting disturbances induced by snake venoms.…”

Section: Bauhinia Forficata Link Fabaceae (Mororó)mentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

show abstract

Section: Bauhinia Forficata Link Fabaceae (Mororó)mentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…Plant extracts have been used for the treatment of snakebites because they contain a wide variety of chemical compounds with pharmacological activities that exert inhibitory activity against the toxins present in snake venom [6][7][8][9] . This plant has antifungal, antimicrobial, bronchodilatory, antiallergic, antihemorrhagic, and anti-inflammatory properties 10 .…”

Section: Introductionmentioning

confidence: 99%

Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats

et al. 2014

View full text Add to dashboard Cite

Conception, design, intellectual and scientific content of the study; critical analysis; final approval. ABSTRACT PURPOSE:To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats. METHODS:Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4. RESULTS: Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata. CONCLUSION:The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom.

show abstract

“…Moreover immunotherapy is relatively inefficient to neutral venom-induced local tissue damage (Gutiérrez et al, 2006;Gibbs and Mackessy, 2009), and antivenoms are not always readily available in some regions of Africa and Asia (Chippaux et al, 1998;Rodrigues et al, 1998). Therefore the search for novel venom inhibitors has expanded to include the possibility of using plants that may neutralize relevant toxins in the venoms and which may be readily available with minimum side effects (Mors et al, 2000;Borges et al, 2001;Biondo et al, 2003;Alam and Gomes, 2003;Januário et al, 2004;Oliveira et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric study of the anti-caseinolytic activity of root extracts of Teclea nobilis and Vepris zambesiaca on Bitis arietans venom

Chayamiti¹

2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms

Cited by 78 publications

References 7 publications

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats

Spectrophotometric study of the anti-caseinolytic activity of root extracts of Teclea nobilis and Vepris zambesiaca on Bitis arietans venom

Contact Info

Product

Resources

About