Anticoagulant activities of goby muscle protein hydrolysates

Nasri, Rim; Amor, Ikram Ben; Bougatef, Ali; Nedjar‐Arroume, Naïma; Dhulster, Pascal; Gargouri, Jalel; Châabouni, Maha Karra; Nasri, Monçef

doi:10.1016/j.foodchem.2012.01.101

Cited by 63 publications

(27 citation statements)

References 28 publications

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“…In the last decade, enzymatic hydrolysis of proteins from marine sources has attracted much attention for the production of bioactive peptides, and the biological activities of peptides have been extensively reported in several studies: hypoglycemic and hypolipidemic effects of protein hydrolysates from zebra blenny muscle [3], antioxidant and angiotensin converting enzyme (ACE) inhibitory activities from goby muscle [4], immunomodulatory effects of protein hydrolysates from rohu egg [5], anticoagulant activity [6], etc.…”

Section: Introductionmentioning

confidence: 99%

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

Lassoued

Mora

Nasri

et al. 2015

Journal of Proteomics

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Section: Introductionmentioning

confidence: 99%

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

Lassoued

Mora

Nasri

et al. 2015

Journal of Proteomics

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“…Furthermore, peptides that possess a charged amino acid at the C-terminal are potent inhibitors of clotting factors (Nasri et al, 2012). In a similar way, a charged amino acid (Lys), which is present at last but one position of the C-terminal end of our peptide, would have contributed to its activity.…”

Section: Determination Of Molecular Mass Of the Peptidementioning

confidence: 81%

“…From the recent research on the subject, it has been recognised that dietary proteins provide a rich source of bioactive peptides (Nasri et al, 2012). The amino acid sequence and molecular weight are greatly influenced by time and temperature of hydrolysis, enzyme : substrate ratio, and thus the biological activity of the peptide also varies (Korhonen & Pihlanto, 2006).…”

Section: Degree Of Hydrolysismentioning

confidence: 99%

A novel anticoagulant peptide from the Nori hydrolysate

Indumathi

Mehta

2016

Journal of Functional Foods

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“…A recent study reported that muscle protein hydrolysates had anticoagulant activity (Nasri et al . ). Another study reported that the hydrolysis of bovine casein resulted in peptides with antithrombotic and anticoagulant activities (Rojas‐Ronquillo et al .…”

Section: Introductionmentioning

confidence: 97%

“…Functional peptides possess immunoregulatory, opioid, antioxidant and antihypertensive activities (Mao et al 2005a,b). A recent study reported that muscle protein hydrolysates had anticoagulant activity (Nasri et al 2012). Another study reported that the hydrolysis of bovine casein resulted in peptides with antithrombotic and anticoagulant activities (Rojas-Ronquillo et al 2012).…”

Section: Introductionmentioning

confidence: 99%

In VitroCalcium-Chelating and Platelet Anti-Aggregation Activities of Soy Protein Hydrolysate Modified by the Alcalase-Catalyzed Plastein Reaction

Zhang

Zhao

2014

Journal of Food Biochemistry

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Soy protein hydrolysate (SPH) (1 mg/mL), generated by alcalase, had a calcium‐chelating activity of 41 mg/g peptide. The alcalase‐catalyzed plastein reaction of SPH was carried out in different media: ethanol–water, methanol–water and water. The effects of SPH and of resulting modified hydrolysates on calcium‐chelating activities and inhibition of calcium precipitation and platelet aggregation were assessed in vitro. The optimum ethanol concentration, alcalase level and reaction temperature for the plastein reaction was 56.8% v/v, 5.26 kU/g peptide and 33.1C, respectively. The modified hydrolysates had better calcium‐chelating activities and stronger inhibition of calcium precipitation and platelet aggregation than SPH. The modified hydrolysate with the highest calcium‐chelating activity showed the strongest inhibitory effects on platelet aggregation and calcium precipitation. The plastein reaction enhances the in vitro calcium‐chelating and platelet anti‐aggregation activities of SPH. Practical Applications In this study, an alcalase‐catalyzed plastein reaction carried out in three media (ethanol–water, methanol–water and water) was used to modify the in vitro calcium‐chelating and platelet anti‐aggregation activities of an alcalase‐generated soy protein hydrolysate. The results revealed that the modified hydrolysates of higher calcium‐chelating activity had stronger inhibitory effects on platelet aggregation and calcium precipitation. The results of this study provide further insight on the enzymatic synthesis of bioactive peptides of higher activity using the plastein reaction.

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Anticoagulant activities of goby muscle protein hydrolysates

Cited by 63 publications

References 28 publications

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

A novel anticoagulant peptide from the Nori hydrolysate

In VitroCalcium-Chelating and Platelet Anti-Aggregation Activities of Soy Protein Hydrolysate Modified by the Alcalase-Catalyzed Plastein Reaction

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