Anticoagulant activities of curcumin and its derivative

Kim, Dong Chan; Ku, Sae Kwang; Bae, Jong Sup

doi:10.5483/bmbrep.2012.45.4.221

Cited by 138 publications

(82 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the effects of Cur on motor function after SCI were observed over the long term. However, Cur has been shown to inhibit the extrinsic and intrinsic pathways of blood coagulation and increase the chance of bleeding by inhibiting factor Xa and thrombin generation in human umbilical vein endothelial cells [39]. Therefore, the time and dosage of Cur should be carefully considered for each patient with SCI.…”

Section: Discussionmentioning

confidence: 99%

Curcumin improves the integrity of blood–spinal cord barrier after compressive spinal cord injury in rats

Cao

Mei

et al. 2014

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Curcumin improves the integrity of blood–spinal cord barrier after compressive spinal cord injury in rats

Cao

Mei

et al. 2014

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…However, claims of such adverse interactions with ginkgo and garlic have not been supported in some studies [55, 56]. Turmeric also has blood thinning properties [57]. Based on small nonrandomised trials, several traditional Chinese herbal medicines are associated with significant adverse effects, including nephrotoxicity [58].…”

Section: Discussionmentioning

confidence: 99%

Use of complementary and alternative medicine by patients with end-stage renal disease on haemodialysis in Trinidad: A descriptive study

Bahall

2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundDespite the paucity of scientific evidence, complementary and alternative medicine (CAM) is widely used for the prevention and treatment of illness, holistic care, and counteracting the adverse effects of conventional medicine (CM). This study investigates the use of CAM by patients with end-stage renal disease (ESRD) on haemodialysis.MethodsThis quantitative study was conducted from November 1, 2014 to December 31, 2014 in the haemodialysis unit at San Fernando General Hospital (San Fernando, Trinidad). Face-to-face questionnaire-based interviews were held with101of 125 eligible patients (response rate, 80.5%) at the chairside during haemodialysis. The completed questionnaires were entered into a secure computer database. Data analysis included descriptive analysis, χ2 tests, and binary logistic regression analysis.ResultsA minority of the patients were CAM users (n = 19; 18.8%). All 19 CAM users took medicinal herbs, 78.9% (n = 15) used spiritual therapy, and 10.5% (n = 2) used alternative systems. Medicinal tea (n = 15; 78.9%), garlic (Allium sativum) (n = 17; 73.7%), and ginger (Zingiber officinale roscoe) (n = 13; 68.4%) were the most commonly used medicinal herbs. Seven (36.8%) patients used Chinese herbal medicines and 3 (15.8%) patients used Aloe vera. All CAM users were willing to use CAM without supervision or monitoring by their doctors while receiving CM. The use of CAM could not be predicted by age, sex, ethnicity, education, religion, marital status, or employment. Nearly all (98%) patients were satisfied with CAM. More than one-third (36.8%) of patients did not disclose their use of CAM to their doctors, who were generally indifferent to such therapy.ConclusionsThe use of CAM by patients with ESRD was relatively infrequent. All patients used medicinal herbs, most patients used spiritual therapy, and a minority of patients used alternative systems. Complementary and alternative medicine was primarily used for spiritual reasons and the likelihood of its use was influenced by family, friends, and other patients. Patients continued using CM with one or more CAM therapies without informing their healthcare providers, which is a major health risk.

show abstract

“…Studies revealed that apart from fatty acids, the unsaponifiable components present in dietary oils have a role in regulating the coagulation system. There are reports that polyphenols possess antithrombotic effects, it was evidenced by a prolonged PT and aPTT (Kim et al, 2012). Chemical analysis of the test oils has revealed that VCO by wet processing retains higher amounts of polyphenols and tocopherols than other test oils (Arunima and Rajamohan, 2013).…”

Section: Discussionmentioning

confidence: 99%

Supplementation of Virgin Coconut Oil Compared with Copra Oil, Olive Oil and Sunflower Oil on Thrombotic Factors in Rats and In Vitro Platelet Aggregation

Sakunthala¹,

Rajamohan²

2016

Int. J. Curr. Res. Biosci. Plant Biol.

View full text Add to dashboard Cite

A b s t r a c t A r t i c l e I n f oVirgin coconut oil (VCO) extracted from fresh coconut kernel is becoming very valuable because of its numerous beneficial properties. In the present study, comparative effect of VCO with copra oil (CO), olive oil (OO) and sunflower oil (SFO) on thrombotic factors and platelet aggregation were investigated. Male Sprague-Dawley rats were fed test oils at 8% level for 45 days along with the synthetic diet. Results demonstrated that compared to CO, a prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT) were observed in VCO fed rats and was comparable with OO and SFO. Supplementation of VCO reduced the coagulation factors namely factor V, fibrin, fibrinogen and thromboxane B2 levels in plasma compared to those fed CO, OO and SFO. Compared to other test oils, platelet aggregating tendency was also reduced in VCO fed rats. The polyphenolic fraction (PF) isolated from VCO inhibited in vitro platelet aggregation induced by ADP compared to PF from other oils. These results indicated that supplementation of VCO has significant antithrombotic effect by inhibiting the activation of platelets and coagulation factors compared to rats fed other test oils.

show abstract

Anticoagulant activities of curcumin and its derivative

Cited by 138 publications

References 34 publications

Curcumin improves the integrity of blood–spinal cord barrier after compressive spinal cord injury in rats

Curcumin improves the integrity of blood–spinal cord barrier after compressive spinal cord injury in rats

Use of complementary and alternative medicine by patients with end-stage renal disease on haemodialysis in Trinidad: A descriptive study

Supplementation of Virgin Coconut Oil Compared with Copra Oil, Olive Oil and Sunflower Oil on Thrombotic Factors in Rats and In Vitro Platelet Aggregation

Contact Info

Product

Resources

About