Anticipating the Attack: Temporal Conditioning During Amygdala Kindling in Rats.

Barnes, Steven J.; Magyar, Orsolya; Pinel, John P. J.; Takahashi, Akiyoshi

doi:10.1037/0735-7044.118.1.89

Cited by 6 publications

(8 citation statements)

References 43 publications

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“…Although the ambulation and grooming behavior shown by young and middle‐aged IER/Fs are opposite, their behaviors were different from those of control rats. In amygdala‐kindling studies, kindled animals show less ambulation in the open field (26,27) and also were less active when they anticipated seizures (28). The results of these studies agree with the open‐field behavior of our young IER/Fs.…”

Section: Discussionmentioning

confidence: 99%

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Open‐field Behaviors and Water‐maze Learning in the F Substrain of Ihara Epileptic Rats

Okaichi

Amano

Ihara³

et al. 2006

Epilepsia

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Summary:Purpose: Genetically epileptic model rats, Ihara epileptic rat (IER/F substrain), have neuropathologic abnormalities and develop generalized convulsive seizures when they reach the age of ∼5 months. Because the neuromorphologic abnormalities are centered in the hippocampus, we expected to observe spatial cognitive deficits. The present study aimed to evaluate emotionality and learning ability of the F substrain of IER.Methods: To determine whether deficits are caused by inborn neuropathologic abnormalities or by repeated generalized convulsions, we tested nine 6-to 12-week-old IER/F rats that had not yet experienced seizures (experiment 1) and nine 7-to 9-month-old IER/F rats that had repeatedly experienced seizures (experiment 2) with identical tasks: an open-field test and the Morris water-maze place and cue tasks.Results: Both groups of IER/Fs showed behaviors that were different from those of control rats in the open-field test, and extensive learning impairments were seen in both the place task, which requires spatial cognition, and the cue task, which does not require spatial cognition but requires simple association learning. Their impaired performance of the cue task indicates that their deficiency was not limited to spatial cognition.Conclusions: Because young IER/F rats without seizure experiences also showed severe learning impairments, genetically programmed microdysgenesis in the hippocampus was suspected as a cause of the severe learning deficits of IER/Fs.

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Section: Discussionmentioning

confidence: 99%

“…Many studies have reported that hippocampus‐kindled animals show various kinds and degrees of learning deficits (23–25). In contrast, amygdala‐kindled rats do not show learning impairment (26) but are known to be less active (26–28).…”

mentioning

confidence: 99%

Open‐field Behaviors and Water‐maze Learning in the F Substrain of Ihara Epileptic Rats

Okaichi

Amano

Ihara³

et al. 2006

Epilepsia

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“…The order of these trials was pseudorandom, with the criterion that each rat received no more than three trials of one type in a row. Thus the time of day was not predictive of the type of trial (CS+ or CS–), in order to avoid temporal conditioning of prestimulation behaviour (Barnes et al ., 2004). On every fourth day, each rat received one trial of each type, in counterbalanced order.…”

Section: Methodsmentioning

confidence: 99%

“…The most provocative findings in Barnes and colleagues' research (Barnes et al ., 2001, 2003, 2004, 2006) are the conditioned effects on ictal measures, such as stage and duration of convulsions. Barnes found that, after amygdaloid kindling, the convulsions were less severe when elicited in the CS– than in the CS+.…”

Section: Introductionmentioning

confidence: 93%

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Conditioning of interictal behaviours, but not ictal behaviours, seizures or afterdischarge threshold, by kindling of the amygdala in rats

Wagner¹,

Corcoran²

2007

Eur J of Neuroscience

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Rats received 45 pairings of kindling or sham stimulation in distinctive contexts before a conditioned place preference/aversion test, to determine whether the stimulation and seizures were rewarding or punishing. After more pairings, rats received kindling stimulation in each context (switch test). Ictal measures in this test included afterdischarge duration, clonus duration, latency to clonus, class of convulsion and falls. After more pairings, afterdischarge threshold was measured in each context. On every fourth day of pairings, the rats' behaviour in the prestimulation interval was recorded, to measure conditioned anticipatory defensive behaviour. We partially replicated the finding of Barnes et al. (2001, Behav. Neurosci., 115, 1065-1072) that conditioned anticipatory responses and conditioned place aversion are associated with the kindling environment. However, there were no conditioned effects on any ictal measures, including afterdischarge threshold. Our results fail to support the hypothesis that conditioning is a universal mechanism for kindling.

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Does Inadvertent Conditioning Contribute to the Major Features of Kindling?

Barnes

Pinel

Advances in Behavioral Biology

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Anticipating the Attack: Temporal Conditioning During Amygdala Kindling in Rats.

Cited by 6 publications

References 43 publications

Open‐field Behaviors and Water‐maze Learning in the F Substrain of Ihara Epileptic Rats

Open‐field Behaviors and Water‐maze Learning in the F Substrain of Ihara Epileptic Rats

Conditioning of interictal behaviours, but not ictal behaviours, seizures or afterdischarge threshold, by kindling of the amygdala in rats

Does Inadvertent Conditioning Contribute to the Major Features of Kindling?

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