Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer's Disease and Related Dementias

Brown, Eric E.; Kumar, Sanjeev; Rajji, Tarek K.; Pollock, Bruce G.; Mulsant, Benoit H.

doi:10.1016/j.jagp.2020.04.010

Cited by 415 publications

(554 citation statements)

References 35 publications

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“…The identified cause was a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since then, infection from SARS-CoV-2 has spread globally, officially becoming a pandemic on March 11, 2020 ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…Increased risk of death in elderly patients with dementia impairment may not be solely due to their vulnerability to SARS-CoV-2 infection ( 8 ), but may also relate to the cognitive, behavioral and psychological effects of rapid environmental changes brought by the pandemic. Worsening of cognitive impairment in elderly patients with dementia has been reported during the few months following the beginning of the pandemic ( 2 , 3 , 9 ). Impaired comprehension of the public health situation and difficulty following restrictive measures has also been reported ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic: Definition, Treatment, and Future Directions

et al. 2020

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Background Neuropsychiatric symptoms (NPS) of dementia, such as anxiety, depression, agitation, and apathy, are complex, stressful, and costly aspects of care, and are associated to poor health outcomes and caregiver burden. A steep worsening of such symptoms has been reported during Coronavirus Disease 2019 (COVID-19) pandemic. However, their causes, their impact on everyday life, and treatment strategies have not been systematically assessed. Therefore, the aim of this review is to provide a detailed description of behavioral and psychopathological alterations in subjects with dementia during COVID-19 pandemic and the associated management challenges. Methods A PubMed search was performed focusing on studies reporting alterations in behavior and mood and treatment strategies for elderly patients with dementia, in accordance with PRISMA guidelines. The following search strategy was utilized: (COVID* OR coronavirus OR “corona vir*” OR SARS-CoV-2) AND (dementia OR demented OR dement* OR alzheimer* OR “pick’s disease” OR “lewy body” OR “mild cognitive” OR mild cognitive impairment OR MCI). Results Apathy, anxiety and agitation are the most frequently NPS during the COVID-19 pandemic and are mainly triggered by protracted isolation. Most treatment strategies rely on pharmacotherapy; technology is increasingly utilized with mixed results. Conclusions NPS of dementia during COVID-19 appear to arise from social restrictions occurring as a consequence of the pandemic. Implementation of caregiver support and the presence of skilled nursing home staff are required to restore social interaction and adjust technological support to the patients’ needs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic: Definition, Treatment, and Future Directions

et al. 2020

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“…Due to circuit breaker restrictions in Singapore, we have seen increased caregiver stress for patients with known behavioural and psychological symptoms of dementia (BPSD). Many of these patients do not comprehend the importance of social distancing (5).…”

Section: Dear Editormentioning

confidence: 99%

The Role of a Geriatrician has Become Even More Important in an Academic Institution during COVID-19

Merchant

Chen

et al. 2020

The Journal of nutrition, health and aging

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“…This is due to their di culty in following the recommendations from public health authorities and the di culty of maintaining isolation during behavioural and psychological symptoms of dementia. In addition, patients with AD often have age and comorbid medical conditions associated with a poor prognosis and mortality from COVID-19 [15]. Few publications are currently available on a direct connection between the pathology of AD and COVID-19.…”

Section: Pathway Analysismentioning

confidence: 99%

A protein interaction map identifies existing drugs targeting SARS-CoV-2

Cava

Bertoli

Castiglioni

2020

Preprint

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Background: Severe acute respiratory syndrome coronavirus (SARS-CoV-2), an emerging Betacoronavirus, is the causative agent of COVID-19. Angiotensin converting enzyme 2 (ACE2), being the main cell receptor of SARS-CoV-2, plays a role in the entry of the virus into the cell. Currently, there are no specific antiviral drugs for the treatment and neither preventive drugs such as vaccines. Results: We proposed a bioinformatics analysis in order to test in silico existing drugs as a fast way to identify an efficient therapy. We found differentially expressed genes in COVID-19 patients correlated with ACE-2 and we explored their direct relations with a network approach. Conclusions: In this network we integrated drug-gene interactions and we proposed several drugs with antiviral activity that, alone or in combination with other treatment options, could be considered as therapeutic approaches against COVID-19.

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Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer's Disease and Related Dementias

Abstract: The COVID-19 pandemic is causing global morbidity and mortality, straining health systems,

Cited by 415 publications

References 35 publications

Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic: Definition, Treatment, and Future Directions

Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic: Definition, Treatment, and Future Directions

The Role of a Geriatrician has Become Even More Important in an Academic Institution during COVID-19

A protein interaction map identifies existing drugs targeting SARS-CoV-2

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