Anticholinesterase activity and metabolite profiling of <i>Syagrus romanzoffiana</i> (Cham.) Glassman leaves and fruits via UPLC–QTOF–PDA–MS

El‐Hawary, Seham S.; Fathy, Fify I.; Sleem, Amany A.; Morsy, Fatma A.; Khadar, Mai S; Mansour, Mai K.

doi:10.1080/14786419.2019.1622113

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…Glassman (Arecaceae) Extract of leaf and fruit Phenols & fatty acids It inhibits AChE activity in the cerebral cortex and cerebellum of rats and exhibits the nootropic effect. Rat [ 138 ] Nonea micrantha (Boraginaceae) Whole plant Extract Flavonoids It inhibits AChE activity along with scavenging free radicals. Enzyme [ 139 ] Convolvulus pluricaulis Choisy (Convolvulaceae) Whole plant Extract Triterpenoids, flavonol glycosides, anthocyanins, and steroids It reduces mRNA expression of the M1 receptor, Choline acetyltransferase, and NGF-TrkA receptor.…”

Section: Current Neurotherapeutics For Admentioning

confidence: 99%

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Tripathi,

Lodhi,

Rai

et al. 2024

DNND

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. While there is currently no cure for AD, several pharmacotherapeutic targets and management strategies have been explored. Additionally, traditional medicinal plants have gained attention for their potential role in AD management. Pharmacotherapeutic targets in AD include amyloid-beta (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, and cholinergic dysfunction. Traditional medicinal plants, such as Ginkgo biloba, Huperzia serrata, Curcuma longa (turmeric), and Panax ginseng, have demonstrated the ability to modulate these targets through their bioactive compounds. Ginkgo biloba , for instance, contains flavonoids and terpenoids that exhibit neuroprotective effects by reducing Aβ deposition and enhancing cerebral blood flow. Huperzia serrata , a natural source of huperzine A, has acetylcholinesterase-inhibiting properties, thus improving cholinergic function. Curcuma longa , enriched with curcumin, exhibits anti-inflammatory and antioxidant effects, potentially mitigating neuroinflammation and oxidative stress. Panax ginseng’s ginsenosides have shown neuroprotective and anti-amyloidogenic properties. The investigation of traditional medicinal plants as a complementary approach to AD management offers several advantages, including a lower risk of adverse effects and potential multi-target interactions. Furthermore, the cultural knowledge and utilization of these plants provide a rich source of information for the development of new therapies. However, further research is necessary to elucidate the precise mechanisms of action, standardize preparations, and assess the safety and efficacy of these natural remedies. Integrating traditional medicinal-plant-based therapies with modern pharmacotherapies may hold the key to a more comprehensive and effective approach to AD treatment. This review aims to explore the pharmacotherapeutic targets in AD and assess the potential of traditional medicinal plants in its management.

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Section: Current Neurotherapeutics For Admentioning

confidence: 99%

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Tripathi,

Lodhi,

Rai

et al. 2024

DNND

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“…The acetylcholinesterase enzyme is responsible for the hydrolysis of acetylcholine, which is considered a key enzyme in the treatment of Alzheimer's disease. Several plants have been reported for their inhibitory activity against acetylcholinesterase [33][34][35]. The essential oil of S. cumini showed moderate inhibitory ability against AChE with an IC 50 value of 32.90 ± 2.10 µg/mL as compared to donepezil (IC 50 = 7.89 ± 1.30 µg/mL) as a reference drug.…”

Section: Acetylcholinesterase Inhibitionmentioning

confidence: 99%

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies

et al. 2021

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Syzygium cumini (Pomposia) is a well-known aromatic plant belonging to the family Myrtaceae, and has been reported for its various traditional and pharmacological potentials, such as its antioxidant, antimicrobial, anti-inflammatory, and antidiarrheal properties. The chemical composition of the leaf essential oil via gas chromatography–mass spectrometry (GC/MS) analysis revealed the identification of fifty-three compounds representing about 91.22% of the total oil. The identified oil was predominated by α-pinene (21.09%), followed by β-(E)-ocimene (11.80%), D-limonene (8.08%), β-pinene (7.33%), and α-terpineol (5.38%). The tested oil revealed a moderate cytotoxic effect against human liver cancer cells (HepG2) with an IC50 value of 38.15 ± 2.09 µg/mL. In addition, it effectively inhibited acetylcholinesterase with an IC50 value of 32.9 ± 2.1 µg/mL. Furthermore, it showed inhibitory properties against α-amylase and α-glucosidase with IC50 values of 57.80 ± 3.30 and 274.03 ± 12.37 µg/mL, respectively. The molecular docking studies revealed that (E)-β-caryophyllene, one of the major compounds, achieved the best docking scores of −6.75, −5.61, and −7.75 for acetylcholinesterase, α-amylase, and α-glucosidase, respectively. Thus, it is concluded that S. cumini oil should be considered as a food supplement for the elderly to enhance memory performance and for diabetic patients to control blood glucose.

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“…A total of 29 compounds were identified, including 3 phenolic acids, 10 flavonoids, and 16 triterpenoids (Table 1). These compounds were 3-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, catechin, isoquercetin, quercetin-3-Oglucuronide, kaempferol-3-O-galactoside, kaempferol-3-O-glucuronide, kaempferol-3-Oglucoside, quercetin-3-O-rhamnoside, myricetin, kaempferol-3-O-rhamnoside, quercetin, kaempferol, 3β,19α,23-trihydroxy-1-oxo-olean-12-en-28-oic acid, arjunolic acid, cyclocaric acid B, asiatic acid, pterocaryoside B, cyclocarioside I, cyclocarioside K, pterocaryoside A, cyclocariol C, (20S,24R)-20,24-epoxy-25-hydroxy-12β-(α-L-arabinopyranosyloxy)-3,4-secodammara-4-( 28)-en-3-oic acid, cyclocarioside B, hederagenin, cyclocarioside H, cyclocarioside X, cypaliuruside E, and ursolic acid [17,[30][31][32][33][34][35][36][37][38][39][40].…”

Section: Characterization Of Chemical Constituents In Cpe Cpf Cpp and Cptmentioning

confidence: 99%

“…A total of 29 compounds were identified, including 3 phenolic acids, 10 flavonoids, and 16 triterpenoids (Table 1). These compounds seco-dammara-4-( 28)-en-3-oic acid, cyclocarioside B, hederagenin, cyclocarioside H, cyclocarioside X, cypaliuruside E, and ursolic acid [17,[30][31][32][33][34][35][36][37][38][39][40].…”

Section: Characterization Of Chemical Constituents In Cpe Cpf Cpp and Cptmentioning

confidence: 99%

Anti-Hyperglycemic Effects of Refined Fractions from Cyclocarya paliurus Leaves on Streptozotocin-Induced Diabetic Mice

et al. 2021

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To identify the chemical components responsible for the anti-hyperglycemic effect of Cyclocarya paliurus (Batal.) Iljinsk (Juglandaceae) leaves, an ethanol extract (CPE) and a water extract (CPW) of C. paliurus leaves, as well as their total flavonoids (CPF), triterpenoids (CPT) and crude polysaccharides (CPP), were prepared and assessed on streptozotocin (STZ)-induced diabetic mice. After being orally administrated once a day for 24 days, CPF (300 mg/kg), CPP (180 mg/kg), or CPF+CPP (300 mg/kg CPF + 180 mg/kg CPP) treatment reversed STZ-induced body weight and muscle mass losses. The glucose tolerance tests and insulin tolerance tests suggested that CPF, CPP, and CPF+CPP showed anti-hyperglycemic effect in STZ-induced diabetic mice. Furthermore, CPF enhances glucose-stimulated insulin secretion in MIN6 cells and insulin-stimulated glucose uptake in C2C12 myotubes. CPF and CPP suppressed inflammatory cytokine levels in STZ-induced diabetic mice. Additionally, CPF and CPP improved STZ-induced diabetic nephropathy assessed by H&E staining, blood urea nitrogen content, and urine creatinine level. The molecular networking and Emperor analysis results indicated that CPF showed potential anti-hyperglycemic effects, and HPLC–MS/MS analysis indicated that CPF contains 3 phenolic acids and 9 flavonoids. In contrast, CPT (650 mg/kg) and CPC (300 mg/kg CPF + 180 mg/kg CPP + 650 mg/kg CPT) did not show anti-hyperglycemic effect. Taken together, polysaccharides and flavonoids are responsible for the anti-hyperglycemic effect of C. paliurus leaves, and the clinical application of C. paliurus need to be refined.

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Anticholinesterase activity and metabolite profiling of Syagrus romanzoffiana (Cham.) Glassman leaves and fruits via UPLC–QTOF–PDA–MS

Cited by 9 publications

References 9 publications

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies

Anti-Hyperglycemic Effects of Refined Fractions from Cyclocarya paliurus Leaves on Streptozotocin-Induced Diabetic Mice

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