Anticholinesterase activities of novel indole-based hydrazide-hydrazone derivatives: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction

Exploiting butyrylcholinesterase inhibitors through a combined 3-D pharmacophore modeling, QSAR, molecular docking, and molecular dynamics investigation

“…The compounds were prepared for docking using the LigPrep tool, and the OPLS-2005 force field was employed. 56 …”

Metal complexes of hydrazone–oxime derivative as promising in vitro antimicrobial agents against some fungal and bacterial strains

“…These chelators and their synthetic complex derivatives have enormous benefit to acquire varied applications in several fields. They have shown considerable antimalarial, 1 anti‐insecticidal, 2 anticancer, 3 anticholinesterase, 4 antitumor, 5,6 anti‐tuberculosis, 7 antifungal, 8–11 antibacterial, 8–11 antihyperglycemic, 12,13 anti‐infective, 14 antiradical, 15 antioxidant, 16–18 antimicrobial, 19,20 antitrypanosome, 21 antidiabetic, anti‐inflammatory, 22,23 antiviral, 23–25 antidepressant and nootropic, 26 and gastroprotective activities 27 . Furthermore, They act as enzyme inhibitors, 23,28–30 catalysts in various reactions, 31–33 and excellent anticorrosion to protect the metals and alloys as steel 34 .…”

Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates

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