Overactive bladder (OAB) is a highly prevalent and bothersome condition that hampers quality of life in men and women. Increased awareness of available treatment has led growing numbers of patients to seek medical attention in search of relief. Clinical algorithms for the management of OAB would enable physicians who treat these patients to deliver up-to-date, effective care in an expeditious fashion. An algorithmic approach to OAB should allow most patients to receive therapy without the need for an extended evaluation. Patients who fail initial management or have more complicated clinical scenarios should have treatment directed by specialists who can precisely determine the nature of vesicourethral dysfunction underlying their symptoms. This article presents algorithms for the management of OAB in women, men, and patients with neurologic disease.