“…It is widely acknowledged that anticholinergic medications have a detrimental impact on cognitive performance (Richardson et al, 2018;López-Álvarez et al, 2019). Due to increasing health complications in later life, the use of polypharmacy in elderly people is high, and many commonly prescribed drugs have anticholinergic effects, including neuropsychiatric drugs (eg tricyclic antidepressants, antipsychotic agents, antiepileptic drugs, antiparkinsonian medication) and a range of non-psychoactive drugs (eg antihistamines, antispasmodics, antiulcer agents, bronchodilators, diuretics, corticoids, cardiovascular medications) (López-Álvarez et al, 2019). A UK case-control study conducted in over 40 000 patients with dementia aged 65-99 years and approximately 284 000 control subjects without dementia found that dementia was associated with an increasing average anticholinergic cognitive burden (ACB) score, and a strong association between some classes of anticholinergic drugs (eg antidepressants, urological agents, and antiparkinsonian drugs) and future dementia incidence (Richardson et al, 2018).…”