Antichlamydial antibody in tears and sera, and serotypes of Chlamydia trachomatis isolated from schoolchildren in Southern Tunisia.

Treharne, J D; Dwyer, R S; Darougar, S; Jones, Barrie R.; Daghfous, T.

doi:10.1136/bjo.62.8.509

Cited by 33 publications

(8 citation statements)

References 18 publications

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“…Their proposal was based on the finding of a high prevalence of antichlamydial IgG antibody in ocular secretions from children with active trachoma, and the fact that higher titres of antichlamydial IgG antibody were found in serum and tears from isolation positive than isolation negative subjects [10][11][12]. On the other hand, ocular secretions from children with trachoma showed neutralizing activity in the owl monkey model [8].…”

Section: Discussionmentioning

confidence: 99%

“…Barenfanger demonstrated that neutralization was mediated in this case by immunoglobulin [9]. Others have found a positive correlation between anti-chlamydial antibody levels and the presence of chlamydia in the conjunctiva of individuals in trachoma endemic communities; indeed the presence of such antibodies has been used as a diagnostic marker of active trachoma [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

et al. 1993

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SUMMARYIn order to study the effect of antichlamydial antibodies in ocular secretions on resistance to ocular chlamydial infection and clearance of this infection, we have performed linked longitudinal studies in a Gambian village in which trachoma is endemic. We have measured IgG and IgA antibody levels to a local serotype B isolate of Chlamydia trachomatis by amplified enzyme immunoassay, and chlamydial antigen levels in conjunctival swabs using a commercially available immunoassav which detects chlamydial glycolipid. Having previously demonstrated that sharing a bedroom with a case of active trachoma is a risk factor for acquisition of the disease, we have analysed the effect of IgG and IgA antibody on the acquisition and persistance of clinical trachoma after controlling for age, sex, exposure to infection and for the presence of chlamydial antigen using a Poisson regression model. We have found that the presence of antichlamydial IgG in ocular secretions of disease-free subjects is associated with an increased incidence of trachoma. IgA antibody shows an opposite trend, but this is not statistically significant. One possible explanation of these findings is that antichlamydial IgG antibodies enhance the infectivity of C. trachomatis for the human eye; this could have major implications for the development of a chlamydial vaccine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

et al. 1993

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“…Reinfection with a different serovar tends to raise antibody responses to the previous serovar (20). There is no evidence that tear antibodies confer protection against chlamydial infection (21,22). Byrne and Krueger have shown that gamma interferon inhibits chlamydial growth and viability in cell cultures and probably serves as one host defense mechanism (23).…”

Section: Immunitymentioning

confidence: 99%

Trachoma: The Forgotten Cause of Blindness

Muñoz

West

1997

Epidemiologic Reviews

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“…Studies of tear immunglobulins using the same animal model, however, revealed a change by three weeks after infection from a predominance of IgM to either IgG or IgA [10]. Antichlamydial IgG and IgA were also the predominant immunoglobulin types (with levels of IgG greater than those of IgA) detected in the tears of patients with active trachoma [11,12]. In the present study, IgG and IgA, with small amounts of IgM, were also found in the subepithelial conjunctival tissue and occasionally IgG and IgA were seen on the epithelial surface.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival lymphocyte subsets in trachoma

et al. 1988

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Monoclonal antibodies were used to assess the lymphocyte populations in conjunctival biopsy specimens obtained from patients with trachoma (active or inactive) undergoing tarsotomy for the correction of trachoma-induced entropion and in three control patients. Peroxidase-labelled monoclonal antibodies OKT4 (identifies T-helper/inducer lymphocytes), OKT8 (identifies T-suppressor/cytotoxic lymphocytes), OKIal (identifies B-lymphocytes) and antisera specific for IgG, IgA and IgM were used to identify lymphocyte subpopulations and immunoglobulins in the conjunctival biopsy specimens. When grouped by disease activity, conjunctival tissue specimens revealed predominant T-helper/inducer lymphocytes in the substantia propria of patients with active trachoma while inactive trachoma patients had predominant T-suppressor/cytotoxic lymphocytes in the conjunctival biopsy specimens. B-lymphocytes were seen in moderate numbers in all conjunctival biopsy specimens from patients with active trachoma and all specimens from active cases stained for IgG, IgM, and IgA. Immunoglobulin staining was strongest with IgG and IgM.

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Antichlamydial antibody in tears and sera, and serotypes of Chlamydia trachomatis isolated from schoolchildren in Southern Tunisia.

Cited by 33 publications

References 18 publications

The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

Trachoma: The Forgotten Cause of Blindness

Conjunctival lymphocyte subsets in trachoma

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