Antichagasic effect of violacein from
            <i>Chromobacterium violaceum</i>

Canuto, Jáder Almeida; Lima, Dânya Bandeira; Menezes, Ramon Róseo Paula Pessoa Bezerra de; Batista, A.H.M.; Nogueira, Patrícia Coelho do Nascimento; Silveira, Edilberto R.; Grangeiro, Thalles Barbosa; Nogueira, Nádia Accioly Pinto; Martins, Alice Maria Costa

doi:10.1111/jam.14391

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…Currently, in our lab, calcium oxalate and uric acid stones dissolving pigments from marine bacteria are being isolated. Prodigiosin from S. marcescens [254] and violacein from C. violaceum [255] promise to treat the chagas disease. Violacein pigment is employed in cotton fabrics dyeing [256], and lead detecting whole-cell lead biosensor [257].…”

Section: Biomedical and Industrial Applicationsmentioning

confidence: 99%

Ecological and Biotechnological Aspects of Pigmented Microbes: A Way Forward in Development of Food and Pharmaceutical Grade Pigments

Ramesh

Dufossé²

2021

Microorganisms

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Microbial pigments play multiple roles in the ecosystem construction, survival, and fitness of all kinds of organisms. Considerably, microbial (bacteria, fungi, yeast, and microalgae) pigments offer a wide array of food, drug, colorants, dyes, and imaging applications. In contrast to the natural pigments from microbes, synthetic colorants are widely used due to high production, high intensity, and low cost. Nevertheless, natural pigments are gaining more demand over synthetic pigments as synthetic pigments have demonstrated side effects on human health. Therefore, research on microbial pigments needs to be extended, explored, and exploited to find potential industrial applications. In this review, the evolutionary aspects, the spatial significance of important pigments, biomedical applications, research gaps, and future perspectives are detailed briefly. The pathogenic nature of some pigmented bacteria is also detailed for awareness and safe handling. In addition, pigments from macro-organisms are also discussed in some sections for comparison with microbes.

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Section: Biomedical and Industrial Applicationsmentioning

confidence: 99%

Ecological and Biotechnological Aspects of Pigmented Microbes: A Way Forward in Development of Food and Pharmaceutical Grade Pigments

Ramesh

Dufossé²

2021

Microorganisms

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“…Similar results were previously reported for violacein extracts used against P. falciparum and P. chabaudi (Lopes et al 2009). In addition, Canuto et al (2019) reported ROS induction and changes in mitochondrial transmembrane using as potential action mechanisms.…”

Section: Violacein Effects On Parasites and On Their Vectorsmentioning

confidence: 99%

Multi-target drug with potential applications: violacein in the spotlight

Nakazato

Durán

Berti

et al. 2021

World J Microbiol Biotechnol

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The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein's action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.

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“…Violacein, a natural colorant produced by some Gramnegative bacteria, showed a predominantly apoptotic effect in developmental forms of T. cruzi (Y strain) and selectivity index of 9 (Canuto et al, 2019). However, the poor aqueous solubility of violacein is a serious obstacle for development pharmaceutical formulations.…”

Section: Lipid Nanosystems Encapsulating Non-approved Drugsmentioning

confidence: 99%

Trypanosomatid-Caused Conditions: State of the Art of Therapeutics and Potential Applications of Lipid-Based Nanocarriers

Muraca¹,

Berti

Sbaraglini³

et al. 2020

Front. Chem.

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Trypanosomatid-caused conditions (African trypanosomiasis, Chagas disease, and leishmaniasis) are neglected tropical infectious diseases that mainly affect socioeconomically vulnerable populations. The available therapeutics display substantial limitations, among them limited efficacy, safety issues, drug resistance, and, in some cases, inconvenient routes of administration, which made the scenarios with insufficient health infrastructure settings inconvenient. Pharmaceutical nanocarriers may provide solutions to some of these obstacles, improving the efficacy–safety balance and tolerability to therapeutic interventions. Here, we overview the state of the art of therapeutics for trypanosomatid-caused diseases (including approved drugs and drugs undergoing clinical trials) and the literature on nanolipid pharmaceutical carriers encapsulating approved and non-approved drugs for these diseases. Numerous studies have focused on the obtention and preclinical assessment of lipid nanocarriers, particularly those addressing the two currently most challenging trypanosomatid-caused diseases, Chagas disease, and leishmaniasis. In general, in vitro and in vivo studies suggest that delivering the drugs using such type of nanocarriers could improve the efficacy–safety balance, diminishing cytotoxicity and organ toxicity, especially in leishmaniasis. This constitutes a very relevant outcome, as it opens the possibility to extended treatment regimens and improved compliance. Despite these advances, last-generation nanosystems, such as targeted nanocarriers and hybrid systems, have still not been extensively explored in the field of trypanosomatid-caused conditions and represent promising opportunities for future developments. The potential use of nanotechnology in extended, well-tolerated drug regimens is particularly interesting in the light of recent descriptions of quiescent/dormant stages of Leishmania and Trypanosoma cruzi, which have been linked to therapeutic failure.

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Antichagasic effect of violacein from Chromobacterium violaceum

Cited by 7 publications

References 37 publications

Ecological and Biotechnological Aspects of Pigmented Microbes: A Way Forward in Development of Food and Pharmaceutical Grade Pigments

Ecological and Biotechnological Aspects of Pigmented Microbes: A Way Forward in Development of Food and Pharmaceutical Grade Pigments

Multi-target drug with potential applications: violacein in the spotlight

Trypanosomatid-Caused Conditions: State of the Art of Therapeutics and Potential Applications of Lipid-Based Nanocarriers

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