Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-mediated chloride current in snail neurons

Epilepsy in lupus

“…aCL antibodies from patients with SLE reduce γ-aminobutyric acid (GABA)-mediated chloride currents in snail neurons. 22 This finding might provide one explanation for a mechanism of seizure precipitation in SLE. Cerebral ischemic changes can be the pathological substrate for seizures either at the post-acute stage when the infarct occurs (acute symptomatic seizures) or at a later stage even months or years afterwards (remote symptomatic seizures).…”

Differential Diagnosis of Central Nervous System Manifestations of the Antiphospholipid Antibody Syndrome

“…aPL have been shown to reduce a GABA receptor-mediated chloride current in snail neurons [51]. This inhibitory effect suggests a direct and reversible mechanism through which aPL might lower seizure threshold.…”

“…There are some animal data that support the possibility of a primary immunologic basis for seizures associated with aPL [50][51][52]. aPL have been shown to reduce a GABA receptor-mediated chloride current in snail neurons [51].…”

Autoimmune Diseases Associated with Epilepsy

“…[46] Bunlar dışında aPL ATP'ye bağlanıp nöronal disfonksiyon ve GABA inhibisyonuna da neden olmaktadır. [47,48] Bu mekanizmalar hastalık seyrinde ortaya çıkan epilepsinin patogenezinde rol oynayabilir.…”