Anticardiolipin antibodies: isotype distribution and phospholipid specificity.

Gharavi, Azzudin E.; Harris, E. N.; Ra, Asherson; Hughes, G. R. V.

doi:10.1136/ard.46.1.1

Cited by 612 publications

(238 citation statements)

References 18 publications

(3 reference statements)

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“…Positive antiphospholipid antibody (aPL) status was defined by the presence of one or more aPL subsets, including lupus anticoagulant and IgG anticardiolipin antibodies (aCL), measured as described previously (19). Briefly, serum IgG aCL antibodies were identified by ELISA, using cardiolipin (Sigma) as a substrate, according to standard methods (20). IgG aCL antibodies with a titer of Ͼ15 IgG phospholipid units were regarded as positive.…”

Section: Methodsmentioning

confidence: 99%

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Mok¹,

Lau²,

Chiu³

et al. 2011

Arthritis & Rheumatism

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Objective. Endothelial dysfunction and inflammation are pathogenic mechanisms common to systemic sclerosis (SSc) and atherosclerosis. This study was undertaken to examine the relationship between coronary atherosclerosis, as assessed by the coronary artery calcium score (CACS), and conventional cardiovascular and disease-specific risk factors in SSc patients.Methods. The CACS was measured by computed tomography, and cardiovascular risk factors were examined in SSc patients and compared with controls matched for age, sex, and glycemic status. Disease activity score, antiphospholipid antibodies, highsensitivity C-reactive protein level, and erythrocyte sedimentation rate were measured in SSc patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined.Results. We recruited 53 SSc patients (50 women and 3 men) and 106 controls. The patients had a mean ؎ SD age of 53.1 ؎ 12.9 years and a median disease duration of 9 years. Compared to controls, SSc patients had significantly lower low-density lipoprotein (LDL) cholesterol levels (P ‫؍‬ 0.001), high-density lipoprotein cholesterol levels (P ‫؍‬ 0.01), diastolic blood pressure, waist circumference, and body mass index and were more likely to be receiving vasodilators (all P < 0.001). There was a significantly higher proportion of SSc patients among subjects with more severe coronary calcification (CACS >101) compared to those with lesser severity (CACS <100) (56.5% versus 29.4%; P ‫؍‬ 0.01). Multiple logistic regression analysis revealed SSc to be an independent determinant for a CACS >101 (OR 10.89 [95% CI 2.21-53.75], P ‫؍‬ 0.003) together with age and LDL cholesterol level after adjustment for other cardiovascular risk factors. Among diseasespecific factors, only disease duration (OR 1.14 [95% CI 1.02-1.27], P ‫؍‬ 0.02) was independently associated with more severe coronary calcification (CACS >101).Conclusion. Our findings indicate that SSc is an independent risk factor for coronary calcification, in addition to the conventional risk factors for coronary atherosclerosis, such as age and hypertension.

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Section: Methodsmentioning

confidence: 99%

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Mok¹,

Lau²,

Chiu³

et al. 2011

Arthritis & Rheumatism

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“…Anticardiolipin antibodies (IgG and IgM isotypes) were measured in serum stored at -20°C by enzyme-linked immunosorbent assay, as described by Gharavi et a1 (8).…”

Section: Methodsmentioning

confidence: 99%

Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus

Herranz¹,

Rivier

Khamashta

et al. 1994

Arthritis & Rheumatism

163

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Objective. To determine whether the occurrence of seizures is correlated with the presence of serum antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) patients.Methods. The study included 221 unselected patients with SLE. Of these, 21 patients with epileptic seizures not attributed to any cause other than SLE were identified. Epilepsy was diagnosed by clinical history and electroencephalography. Blood samples were tested for the presence of antibodies to cardiolipin (aCL, IgG and IgM isotypes) and lupus anticoagulant (LAC).Results. LAC was detected in 43.8% of the patients with epilepsy and in 20.8% of controls (P = 0.057). A statistically significant association was found between moderate-to-high titers of IgG aCL and the presence of seizures (P = 0.02). Brain computed tomography and/or magnetic resonance imaging scanning was performed in 14 patients. All patients with abnormal features found on these tests had positive aPL (P = 0.03). Nine patients (42.9%) had at least 1 of the classic features associated with the aPL syndrome. Conclusion. We confirmed that epilepsy as a primary neuropsychiatric event is significantly associated with moderate-to-high titers of IgG aCL in SLE

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“…More recently, it has become apparent that antibodies (all three idiotypes: IgG, IgA, and IgM) to B-2-GP-I, phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, annexin-V, or phosphatidylcholine are independent risk factors for thrombosis of all types (types I-V) [66]. Although there is an association between the LA and ACLAs and an association among LAs and the aforementioned syndromes, it has become clear that LAs, ACLAs, and antibodies to B-2-GP-I, phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, phosphatidylcholine, or annexin-V are separate entities; most individuals with ACLAs do not have an LA, and most with the LA do not have ACLAs [67]. Many with subgroups harbor ACLAs, but 10% to 20% of patients demonstrate discordance [68], and subgroups are present in the absence of positive ELISA assays for ACLAs or LA.…”

Section: Anticardiolipin Antibodies ''Subgroup'' Antibodies and Thrmentioning

confidence: 99%

Antiphospholipid thrombosis syndromes

Bick

2003

Hematology/Oncology Clinics of North America

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Anticardiolipin antibodies: isotype distribution and phospholipid specificity.

Cited by 612 publications

References 18 publications

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus

Antiphospholipid thrombosis syndromes

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