Anticardiolipin Antibodies in Migraine

Hering, R.; Couturier, E. G. M.; Steiner, TJ; Asherson, Ronald A.; Fc, Rose

doi:10.1046/j.1468-2982.1991.1101019.x

Cited by 28 publications

(23 citation statements)

References 32 publications

(28 reference statements)

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“…Studies performed on migraine patients and on patients with systemic lupus erythematosus [19. 20] did not suggest any specific association between migraine and aPLs [18], Moreover, we recently investi gated the prevalence of aPLs in a population of migraine patients attending our Migraine Outpatients Service. The presence of aCAs and/or LA was detected in only 3 out of 197 consecutive patients.…”

Section: Discussionmentioning

confidence: 98%

“…In particular, the wide number of descriptions of association of LA and aCAs with migraine has suggested their possible pathogenetic implication in vascular headache [13,[15][16][17], However, such a hypothesis has not been supported by recent inves tigations performed on migrainous patients [18] and on patients with systemic lupus erythematosus [19,20] that failed to show any specific association between migraine and aPLs. These conflicting results could be explained by the hypothesis that the association between aPLs and migraine concerns only a particular group of patients.…”

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confidence: 99%

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Migrainous Stroke and the Antiphospholipid Antibodies

et al. 1994

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The pathogenesis of migrainous stroke is controversial. The possibility that a number of migraine-related strokes is associated with the presence of antiphospholipid antibodies, a condition predisposing to coagulopathy, has been suggested. We investigated the prevalence of lupus anticoagulant and anticardiolipin antibodies in patients with migrainous stroke. In 6 out of 16 patients with migrainous cerebral infarction, the presence of antiphospholipids antibodies was detected. In such patients, the presence of other risk fators for stroke was significantly lower (%² = 5.6; p = 0.01) with respect to patients with negative results for antiphospholipid antibodies. These results suggest that antiphospholipid antibodies associated with migraine may be an important marker for ischemic stroke.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Migrainous Stroke and the Antiphospholipid Antibodies

et al. 1994

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“…Hering ct al. [42] studied the preva lence of ACLA in a series of 94 patients with migraine (35 with aura. 59 without aura) and found weakly positive ACLA levels in only one patient [42].…”

Section: Discussionmentioning

confidence: 99%

Anticardiolipin Antibodies in Oculocerebral Ischaemia and Migraine: Prevalence and Prognostic Value

Hinse¹,

Schulz²,

Haag

et al. 1993

Cerebrovasc Dis

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We prospectively studied the prevalence and prognostic value of anticardiolipin antibodies (ACLA) in 72 unselected patients with acute or chronic oculocerebral ischaemia (OCI) and 25 patients with migraine. ACLA were measured by ELISA. ACLA titres above 12 GPL-U/ml or 6 MPL-U/ml were considered abnormal. Thirty-two of 72 patients with OCI (44%) showed weakly elevated IgG- or IgM-ACLA (i.e. < 20 GPIVMPL-U/ml). In 9 patients (12%) ACLA titres were above 20 GPL/MPL-U/ml. High ACLA titres in patients with OCI were associated with a significantly increased risk for recurrent cerebral ischaemia. In patients with low ACLA titres, recurrence of ischaemia was no more frequent than in ACLA-negative patients. We suggest that weakly elevated ACLA have no potency for inducing a prothrombotic state and therefore are of no clinical relevance in stroke patients. Serial studies of ACLA titres performed in some patients showed marked fluctuation over time indicating that single determinations should be interpreted with caution. Fifteen of 25 patients with migraine (60%) showed weakly (n = 14, 56%) or highly positive (n = 1, 4%) ACLA titres. Whether ACLA assume a pathogenetic role in migraine remains unknown.

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“…Dem steht entgegen, daß z. B. Markus und Hopkinson [18] in einer Gruppe von 90 Patienten mit SLE keine Korrelation zwischen Migräne und aCL-AK und Hering et al [14] nur eine Inzidenz von 4% erhöhte aCL-AK fanden.…”

Section: Chronischer Spannungskopfschmerzunclassified

Antinukleäre- und Anticardiolipinantikörper bei primären Kopfschmerzsyndromen

et al. 1998

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Our finding of increased incidence of positive anticardiolipin IgG antibodies in migraine patients (also reported in other studies) raises the question if these antibodies unspecifically support the occurrence of a migraine attack by increasing the interaction of blood cells and the endothelium. Furthermore, we discuss whether the observed increased incidence of strokes in patients with migraine may in part be caused by the also increased incidence of anticardiolipin antibodies, which are an independent risk factor for stroke.

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Anticardiolipin Antibodies in Migraine

Cited by 28 publications

References 32 publications

Migrainous Stroke and the Antiphospholipid Antibodies

Migrainous Stroke and the Antiphospholipid Antibodies

Anticardiolipin Antibodies in Oculocerebral Ischaemia and Migraine: Prevalence and Prognostic Value

Antinukleäre- und Anticardiolipinantikörper bei primären Kopfschmerzsyndromen

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