Anticardiolipin antibodies—clinical associations

Asherson, Ronald A.; Harris, E. N.

doi:10.1136/pgmj.62.734.1081

Cited by 133 publications

(70 citation statements)

References 49 publications

(35 reference statements)

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“…1318 Two patients (cases 14 and 16) tested positive for anticardiolipin antibodies. An association between anticardiolipin antibodies and cerebral infarcts has been encountered with increasing frequency, 25 but only one case of cocaine-related stroke has been previously reported to have anticardiolipin antibodies. 26 We included case 17 in the series because of the clear temporal relation between the use of crack and the onset of the symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…2 -22 Strokes were initially described as isolated case reports 13 -4 ' 6 -7 or were incorporated in articles describing medical complications of cocaine. 25 As the frequency of cocaine use increased, cocaine-related strokes became part of larger series on neurologic complications of cocaine 14 or series on intracranial hemorrhages or ischemic infarcts, 13 ' 15161822 reflecting the continuous increase in their frequency.…”

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confidence: 99%

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Central nervous system infarction related to cocaine abuse.

Daras

Tuchman

Marks

1991

Stroke

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Background: Cocaine use in the United States has reached epidemic proportions, and increased availability of "crack" since 1983 has noticeably increased the incidence of neurovascular complications. In this report, we examine the relationship between cocaine use and ischemic infarct.Summary of Comment: This study reports 18 cases of ischemic cerebrovascular events, which occurred among 15 men and three women aged 21-47 years who were evaluated in a 2-year period. Clinical presentations include thirteen cases with hemispheric infarcts, two brain stem strokes, two anterior spinal artery infarcts, and one with both hemispheric and cerebellar infarcts. Nine patients smoked crack, four snorted cocaine, and three injected it intravenously. In two cases, the route of administration could not be determined. Two patients died, but the others survived with various degrees of neurological deficit.Conclusions: Traditional risk factors for strokes were identified in only six patients, suggesting that these factors are not necessary for the occurrence of a cocaine-related infarct. Multiple overlapping mechanisms may be responsible, including vasospasm, sudden onset of hypertension, myocardial infarction with cardiac arrhythmias, increased platelet aggregation, and vasculitis. (Stroke 1991;22:1320-1325)

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Central nervous system infarction related to cocaine abuse.

Daras

Tuchman

Marks

1991

Stroke

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“…There is poor correlation between patients with thrombosis harboring ACLAs and those harboring LAs, and stronger, but still not concordant, correlation between patients with thrombosis with ACLAs and those with antibodies to B-2-GP-I or antibodies to phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, annexin-V, and phosphatidylcholine. Although there are similarities, there are, at times, clinical, laboratory, and biochemical differences, particularly regarding prevalence, etiology, possible mechanisms of thrombosis, clinical presentations, diagnosis, and at times, management [4,5]. The ACLA-thrombosis antiphospholipid syndrome is much more common than the LA-thrombosis antiphospholipid syndrome, the ratio being approximately 5 to 1 [3,6,7].…”

Section: Antiphospholipid Syndromementioning

confidence: 99%

Antiphospholipid thrombosis syndromes

Bick

2003

Hematology/Oncology Clinics of North America

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“…1,2 There are different subgroups of APLA. The most characterize include lupus anticoagulant (LA), anticardiolipin (ACA), anti-glycoprotein 1 based on detection methods.…”

Section: Introductionmentioning

confidence: 99%