Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells

Arcidiacono, Paola; Stabile, Anna Maria; Ragonese, Francesco; Pistilli, Alessandra; Calvieri, Stefano; Bottoni, Ugo; Crisanti, Andrea; Spaccapelo, Roberta; Rende, Mario

doi:10.1016/j.fct.2018.01.051

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…However, it was recently reported that the various biological effects of SFN can be attenuated from the presence of other biological factors, in vivo (e.g., the nerve growth factor, etc. ), suggesting that a better understanding in the interaction of these compounds with other elements in the body is crucial in order to determine their in vivo efficacy [319].…”

Section: Itcs As Anti-melanoma Agentsmentioning

confidence: 99%

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

et al. 2019

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Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.

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Section: Itcs As Anti-melanoma Agentsmentioning

confidence: 99%

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

et al. 2019

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“…They also reported that SFN upregulated the expression of pro-apoptotic genes, including p53, Bax, PUMA, Fas, MDM2, EGR1, GADD45b, ATF3, and CDKN1A. Subsequently, the same research team observed that SFN treatment shifted the growth factor receptor ratio from prosurvival to proapoptotic one, with a measurable increase in apoptosis in A375 human malignant melanoma cells [ 213 ].…”

Section: Sulforaphane In Cancer Prevention and Interventionmentioning

confidence: 99%

Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

Kaiser

Baniasadi

Giansiracusa

et al. 2021

Cancers

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There is substantial and promising evidence on the health benefits of consuming broccoli and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin, is metabolized to SFN by the thioglucosidase enzyme myrosinase. SFN is the major mediator of the health benefits that have been recognized for broccoli consumption. SFN represents a phytochemical of high interest as it may be useful in preventing the occurrence and/or mitigating the progression of cancer. Although several prior publications provide an excellent overview of the effect of SFN in cancer, these reports represent narrative reviews that focused mainly on SFN’s source, biosynthesis, and mechanisms of action in modulating specific pathways involved in cancer without a comprehensive review of SFN’s role or value for prevention of various human malignancies. This review evaluates the most recent state of knowledge concerning SFN’s efficacy in preventing or reversing a variety of neoplasms. In this work, we have analyzed published reports based on in vitro, in vivo, and clinical studies to determine SFN’s potential as a chemopreventive agent. Furthermore, we have discussed the current limitations and challenges associated with SFN research and suggested future research directions before broccoli-derived products, especially SFN, can be used for human cancer prevention and intervention.

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“…Numerous phytomedicines derived from natural plant or fruit extracts exhibit anticancer activities against cell proliferation, survival, migration, metastasis and angiogenesis in vitro and in vivo. It has been previously reported that acacetin, isoangustone A, sulforaphane and tryptanthrin inhibited melanoma cell proliferation and tumor growth, and induced cell cycle arrest and apoptosis by directly or indirectly targeting PI3K/AKT/mTOR signaling pathways [ 26 , 27 , 28 , 29 ]. Here we describe the mechanisms of the latest natural inhibitors targeting AKT kinase and related signaling pathways in skin cancer preclinical studies in vitro and in vivo (Tables 1 and 2, Figure 3 ).…”

Section: Akt and Related Signaling Pathway Inhibitors For Skin Canmentioning

confidence: 99%

Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways

Hwang

Chae

Kwak

et al. 2020

IJMS

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Global environmental pollution has led to human exposure to ultraviolet (UV) radiation due to the damaged ozone layer, thereby increasing the incidence and death rate of skin cancer including both melanoma and non-melanoma. Overexpression and activation of V-akt murine thymoma viral oncogene homolog (AKT, also known as protein kinase B) and related signaling pathways are major factors contributing to many cancers including lung cancer, esophageal squamous cell carcinoma and skin cancer. Although BRAF inhibitors are used to treat melanoma, further options are needed due to treatment resistance and poor efficacy. Depletion of AKT expression and activation, and related signaling cascades by its inhibitors, decreases the growth of skin cancer and metastasis. Here we have focused the effects of AKT and related signaling (PI3K/AKT/mTOR) pathways by regulators derived from plants and suggest the need for efficient treatment in skin cancer therapy.

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Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells

Cited by 10 publications

References 42 publications

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways

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