Anticandidal activity of Santolina chamaecyparissus volatile oil

Suresh, B.; Sriram, S.; Dhanaraj, S. A.; Elango, K; Chinnaswamy, Krishnapriya

doi:10.1016/s0378-8741(96)01490-0

Cited by 61 publications

(29 citation statements)

References 2 publications

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“…The specific anticandidal activity of such compounds is also well established (Nenoff et al, 1996;Suresh et al, 1997). Previously, we reported the anticandidal effects of essential oils, including cinnamaldehyde Ahmad et al, 2010Ahmad et al, , 2011Shreaz et al, 2010).…”

Section: Introductionmentioning

confidence: 83%

Influences of cinnamic aldehydes on H+ extrusion activity and ultrastructure of Candida

Shreaz

Bhatia

Khan

et al. 2013

Journal of Medical Microbiology

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The antifungal effects of cinnamaldehyde, 4-hydroxy-3-methoxycinnamaldehyde (coniferyl aldehyde) and 3,5-dimethoxy-4-hydroxycinnamaldehyde (sinapaldehyde) were investigated against 65 strains of Candida (six standard, 39 fluconazole-sensitive and 20 fluconazoleresistant). MICs of cinnamaldehyde, coniferyl aldehyde and sinapaldehyde ranged from 100 to 500 mg ml "1 , 100 to 300 mg ml "1 and 100 to 200 mg ml "1 , respectively. All tested isolates showed a marked sensitivity towards these aldehydes in spot and time-kill assays. Sinapaldehyde was found to be the most effective, followed by coniferyl aldehyde and cinnamaldehyde. At their respective MIC 90 values, the three compounds caused mean inhibition levels of glucosestimulated H + -efflux of 36, 34 and 41 % (cinnamaldehyde), 41, 42 and 47 % (coniferyl aldehyde) and 43, 45 and 51 % (sinapaldehyde) for standard-sensitive, clinical-sensitive and clinicalresistant isolates, respectively. Inhibition levels of H + -efflux caused by plasma membrane ATPase inhibitors N,N9-dicyclohexylcarbodiimide (100 mM) and diethylstilbestrol (10 mM) were 34, 45 and 44 %, and 57, 39 and 35 %, for standard-sensitive, clinical-sensitive and clinical-resistant isolates, respectively. Intracellular pH (pHi) was found to decrease by 0.34, 0.42 and 0.50 units following incubation with three tested aldehydes from the control pHi of 6.70. Scanning electron microscopy and transmission electron microscopy analysis was performed on a representative strain, C. albicans 10261, showing alterations in morphology, cell wall, plasma membrane damage and lysis. Haemolytic activity of the three compounds varied from 10 to 15 % at their highest MIC compared to an activity level of 20 % shown by fluconazole at 30 mg ml "1 . In conclusion, this study shows significant activity of cinnamic aldehydes against Candida, including azole-resistant strains, suggesting that these molecules can be developed as antifungals.

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Section: Introductionmentioning

confidence: 83%

Influences of cinnamic aldehydes on H+ extrusion activity and ultrastructure of Candida

Shreaz

Bhatia

Khan

et al. 2013

Journal of Medical Microbiology

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“…To enhance the efficacy of EOs, the combined use of different oils has been evaluated recently for potential synergistic effects. The combination of EOs with synthetic antifungals will probably result in a more effective therapy [17][18][19][20]. Shin and Lim [2] concluded that the antifungal effects of ketoconazole against Trichophyton spp.…”

Section: Discussionmentioning

confidence: 99%

Anti-dermatophyte efficacy and environmental safety of some essential oils commercial and in vitro extracted pure and combined against four keratinophilic pathogenic fungi

Ibrahim

El-Salam

2015

Environ Health Prev Med

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Aim Establish new biocontrol practices with low persistence in the environment against dermatophyte causing mycosis. Methods Antimycotic activity of twenty-six plant-derived commercial essential oils (EOs) was evaluated against four dermatophyte keratinophilic fungi (Microsporum canis, Epidermophyton floccosum, Trichophyton rubrum and Trichophyton mentagrophytes). Commercial EOs which showed the strongest mycelial growth inhibitions were selected and re-extracted in vitro from fresh plant samples. Minimal inhibition concentration (MIC) and antifungal index (AI) of pure and combined extracted oils and were evaluated. All samples were collected and examined during the year of 2014. Results The results revealed that commercial EOs of Prunus armeniaca, Prunus dulcis var. amara, Olea europaea and Mentha piperita were the most potent antidermatophyte. The mixture of the extracted four oils was the strongest fungicides followed by the alternative two-oil combined extractions then pure extracted oils. MIC was at 50, 25 and 12.5 lg/disc for pure oils, two-oil combinations and four-oil mixture, respectively. Achieved values of AI were found variable. Conclusion Using of natural products like plant-derived EOs instead of chemotherapy on pathogens can be regarded as an environmental safety mode of diseases control.

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“…Several compounds with antifungal activity have been isolated and grouped (Alka Agarwal et al, 1994). The anticandidal activity of Santolina oil has been reported (Suresh et al, 1997). This report deals with the fungicidal and fungistatic effects of medicinal plants against Candida albicans.…”

Section: Introductionmentioning

confidence: 95%