Anticancer properties of medicinal plants and their bioactive compounds against breast cancer: a review on recent investigations

Khan, Muhammad Idrees; Bouyahya, Abdelhakim; Menyiy, Naoual El; Akram, Muhammad; Sultana, Sabira; Zengin, Gökhan; Пономарева, Л. Ф.; Shariati, Mohammad Ali; Ojo, Oluwafemi Adeleke; Dall’Acqua, Stefano; Elebiyo, Tobiloba Christiana

doi:10.1007/s11356-021-17795-7

Cited by 48 publications

(36 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ E ] -1 -( 4 -( 4 -( d i m e t h y l a m i n o ) p h e n y l ) -6 -m e t h y l -2 -t h i o x o -1 , 2 , 3 , 4 -t e t r a h y d r o p y r i m idin-5-yl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one (2a). Yield 92%; mp 130 °C; 1…”

Section: General Methods For the Synthesis Of Chalcones (2a B)mentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells

Salem

Gerges

Noser

2022

Sci Rep

View full text Add to dashboard Cite

In the present investigation, derivatives from (2–6) containing pyrimidine-2-thione moiety incorporated with different heterocycles such as pyrazoline, phenyl pyrazoline, and pyrimidine were synthesized using different methods. These pyrimidine-2-thione derivatives were evaluated in-silico for their capability to inhibit the H-RAS-GTP active form protein with insight to their pharmacokinetics properties. According to our findings, compound 5a was selected for in vitro studies as it has the in-silico top-ranked binding energy. Furthermore, compound 5a induced apoptosis to panels of cancer cell lines with the best IC50 on MCF-7 breast cancer cells (2.617 ± 1.6 µM). This effect was associated with the inhibition of phosphorylated RAS, JNK proteins, and PI3K/Akt genes expression. Thus, compound 5a has upregulated p21 gene and p53 protein levels. Moreover, 5a arrested the cell cycle progression at the sub-G0/G1 phase. In conclusion, the synthesized compound, 5a exhibited potent antineoplastic activity against breast cancer cell growth by targeting RAS/ PI3K/Akt/ JNK signaling cascades.

show abstract

Section: General Methods For the Synthesis Of Chalcones (2a B)mentioning

confidence: 99%

“…Currently, the backbone of therapy for breast cancer is mainly chemotherapy, however, the majority of its chemotherapeutic medications are associated with toxicity in normal cells and drug resistance. Therefore, there is an urgent need for the development of effective, and pharmacologically safe antineoplastic agents to treat breast cancer 1 .…”

mentioning

confidence: 99%

Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells

Salem

Gerges

Noser

2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Recently, NPs derived from plants have shown unique advantages in the management of cancer, particularly in the battle against drug resistance [ 54 , 55 ]. Reviewing the literature revealed that a subset of NPs causes apoptosis in tumor cells by suppressing pro-survival autophagy.…”

Section: Natural Products Overcome Autophagy-mediated Tumor Drug Resi...mentioning

confidence: 99%

Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance: An Autophagy-Based Perspective

Yao

Feng

et al. 2022

Biomolecules

View full text Add to dashboard Cite

Autophagy is a critical cellular adaptive response in tumor formation. Nutritional deficiency and hypoxia exacerbate autophagic flux in established malignancies, promoting tumor cell proliferation, migration, metastasis, and resistance to therapeutic interventions. Pro-survival autophagy inhibition may be a promising treatment option for advanced cancer. Furthermore, excessive or persistent autophagy is cytotoxic, resulting in tumor cell death. Targeted autophagy activation has also shown significant promise in the fight against tumor drug resistance. Several research groups have examined the ability of natural products (NPs) such as alkaloids, terpenoids, polyphenols, and anthraquinones to serve as autophagy inhibitors or activators. The data support the capacity of NPs that promote lethal autophagy or inhibit pro-survival autophagy from being employed against tumor drug resistance. This paper discusses the potential applications of NPs that regulate autophagy in the fight against tumor drug resistance, some limitations of the current studies, and future research needs and priorities.

show abstract

“…Furthermore, due to poverty and the high cost of biological analysis and treatment, access to this type of treatment remains limited in rural Morocco and other developing countries [ 6 ]. As a result, cancer has become one of the medical challenges that has resulted in an unacceptably high death toll in these areas [ 8 , 9 ]. Thus, there is a need to revert to homegrown solutions, such as exploring the flora of our own country, Morocco, which is part of the North African botanical block and is home to approximately 4,200 taxa, 32% (1350 taxa) of which are endemic [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

Benkhaira

Ferioun

Kandsi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Cancer is one of the major medical challenges, with an unacceptably high death toll worldwide. In Morocco, medicinal plants continue to play a pivotal therapeutic role despite the development of modern sanitation systems. In the current study, an ethnobotanical survey was carried out at the Moroccan national institute of oncology, Rabat, and we aimed at (1) establishing an exhaustive inventory of indigenous knowledge of Moroccan medicinal plants used to manage cancer and (2) confirming the reported ethnopharmacological uses through bibliometric review. An ethnobotanical survey was conducted with 291 cancer patients at the Moroccan National Institute of Oncology, Rabat, during a period of 4 months, from February to May 2019, through semistructured interviews. Ethnobotanical indices, including informant consensus factor (FIC), use report (UR), relative frequency citation (RFC), botanical family use value (FUV), fidelity level (FL), and index of agreement on remedies (IAR), were employed in data analyses. The survey revealed that 39 medicinal plants belonging to 27 botanical families and 38 genera were used to treat cancer. The most used ethnospecies were Aristolochia longa with the highest RFC value (0.096), followed by Nigella sativa, Ephedra alata, Euphorbia resinifera, and Lavandula dentata, éwith RFC values of 0.072, 0.054, 0.044, and 0.044, respectively. In regard to the plant families, Lamiaceae contributed the highest number of plants with five species (FUV = 0.034), followed by Asteraceae (4 species; FUV = 0.020), and Fabaceae (4 species; FUV = 0.020). The leaves are the most popular plant part used by the studied population against cancer; otherwise, decoction was the most commonly used method for remedy preparation and the highest FIC was noticed for uterine cancer treatment (0.86). Considering these findings, further investigations into the recorded plant species should be performed to assess phytochemical constituents and pharmaceutical benefits in order to identify their active compounds for any drug formulations.

show abstract

Anticancer properties of medicinal plants and their bioactive compounds against breast cancer: a review on recent investigations

Cited by 48 publications

References 170 publications

Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells

Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells

Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance: An Autophagy-Based Perspective

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

Contact Info

Product

Resources

About