Anticancer properties of astaxanthin: A molecule of great promise

Demirel, Pınar; Tuna, Bilge Güvenç

doi:10.1016/b978-0-12-823304-7.00003-9

Cited by 4 publications

(1 citation statement)

References 83 publications

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“…Among these bioactive ingredients, astaxanthin (3, 3′-dihydroxy-β, β′-carotene-4, 4′-dione, Asta) is famous for its strong antioxidant activity, with 10 times the antioxidant activity of β-carotene and lutein, and is about 100 times more effective than α-tocopherol [ 2 , 3 ]. In addition, Asta can reduce cardiovascular disease and improve anti-cancer and immune systems [ 4 , 5 ]. However, natural Asta is sensitive to environmental factors, such as light, heat, and ionic strength, etc., which will lead to Asta degradation, undesirable product generation and functional property loss [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Property and Stability of Astaxanthin Emulsion Based on Pickering Emulsion Templating with Zein and Sodium Alginate as Stabilizer

Jia

Wang

et al. 2022

IJMS

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Astaxanthin loaded Pickering emulsion with zein/sodium alginate (SA) as a stabilizer (named as APEs) was developed, and its structure and stability were characterized. The encapsulation efficiency of astaxanthin (Asta) in APEs was up to 86.7 ± 3.8%, with a mean particle size of 4.763 μm. Freeze-dried APEs showed particles stacked together under scanning electronic microscope; whereas dispersed spherical nanoparticles were observed in APEs dilution under transmission electron microscope images. Confocal laser scanning microscope images indicated that zein particles loaded with Asta were aggregated with SA coating. X-ray diffraction patterns and Fourier transform infrared spectra results showed that intermolecular hydrogen bonding, electrostatic attraction and hydrophobic effect were involved in APEs formation. APEs demonstrated non-Newtonian shear-thinning behavior and fit well to the Cross model. Compared to bare Asta extract, APEs maintained high Asta retention and antioxidant activity when heated from 50 to 10 °C. APEs showed different stability at pH (3.0–11.0) and Na+, K+, Ca2+, Cu2+ and Fe2+ conditions by visual, zeta potential and polydispersity index measurements. Additionally, the first order kinetics fit well to describe APEs degradation at pH 3.0 to 9.0, Na+, and K+ conditions. Our results suggest the potential application of Asta-loaded Pickering emulsion in food systems as a fortified additive.

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Section: Introductionmentioning

confidence: 99%

Property and Stability of Astaxanthin Emulsion Based on Pickering Emulsion Templating with Zein and Sodium Alginate as Stabilizer

Jia

Wang

et al. 2022

IJMS

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Clinical Applications of Haematococcus

Hassi,

Ouaddi,

ElKheloui

et al. 2023

Haematococcus

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Astaxanthin Binding Affinity to DNA: Studied By Fluorescence, Surface Plasmon Resonance and Molecular Docking Methods

et al. 2023

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Astaxanthin (Ax), as a novel food supplement, a pink-red pigment, belongs to the carotenoid family. The study of DNA interactions with various drugs is very important for estimating the mechanism of interaction and developing new drugs. The purpose of this study is to investigate the binding a nity of Ax to double strand (ds) DNA evaluated by using a uorescence spectroscopy, surface plasmon resonance (SPR) and docking approaches. The uorescence results shown that Ax can quench the intensity amount of DNA uorescence via a static quenching way. In the SPR method, DNA molecules were attached on a gold sensor surface. Using different amounts of ds DNA, the kinetic values K D , K A , and K a were calculated. The obtained nding con rm that the binding of Ax to DNA has an exothermic and spontaneous mechanism. Also, thermodynamic studies were carried out using uorescence analysis at four different temperatures, and the resulted negative data for ΔH and ΔS displayed that the main binding strength in the interaction of Ax to DNA was hydrogen bonding. Molecular docking results con rmed that the side chains of Ax interact speci cally with base pairs and the DNA backbone. HighlightsThe binding strength of astaxanthin (Ax) to double strands (ds) DNA was investigated.The uorescence results shown that Ax can quench the DNA.The obtained negative values for ΔH and ΔS indicated that the binding of Ax to DNA was spontaneous process.Major binding force involved in intercalation of AX to DNA was hydrogen bonding.Molecular docking results con rmed that the side chains of Ax interact with DNA.

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Anticancer properties of astaxanthin: A molecule of great promise

Cited by 4 publications

References 83 publications

Property and Stability of Astaxanthin Emulsion Based on Pickering Emulsion Templating with Zein and Sodium Alginate as Stabilizer

Property and Stability of Astaxanthin Emulsion Based on Pickering Emulsion Templating with Zein and Sodium Alginate as Stabilizer

Clinical Applications of Haematococcus

Astaxanthin Binding Affinity to DNA: Studied By Fluorescence, Surface Plasmon Resonance and Molecular Docking Methods

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