Anticancer potential of ß-Sitosterol in experimental colon cancer

Nano Engineering of Artificial Granulocytes for Cancer Diagnosis and Therapeutics

“…The cancer cell killing mechanism has been well explained by Zheng Cui in several of his publications. [13][14][15] In these works, he found granulocytes e®ectively target and kill a fundamentally di®erent health invader: cancer cells. Based on this¯nding, he developed a clinically useful in vitro assay for examining the \lethalness" of the cancer killer cells: granulocytes, de¯ned as cancer killing activity (CKA).…”

“…Based on this¯nding, he developed a clinically useful in vitro assay for examining the \lethalness" of the cancer killer cells: granulocytes, de¯ned as cancer killing activity (CKA). [13][14][15] CKA can be determined directly by coincubating leukocytes with various tumor targets. CKA is normalized as the percentage of total target cells at selected e®ector to target cell ratio in comparison to no-e®ector-cell controls.…”

“…CKA is normalized as the percentage of total target cells at selected e®ector to target cell ratio in comparison to no-e®ector-cell controls. [13][14][15] Using this procedure, Cui and his colleagues were able to determine CKA levels in di®erent human control groups and found consistent variations between the healthy individuals and cancer patients. They then concluded CKA as an e®ective indicator on the immunological anti-cancer ability of any individual.…”

“…Based on these¯ndings, they proposed a novel therapeutic concept, namely, granulocyte infusion therapy (GIT) that utilizes active granulocytes from healthy donors for cancer patients with signi¯cantly weakened immune systems characterized by low CKA levels. [13][14][15]…”