Anticancer Potential of Mangrove Plants: Neglected Plant Species of the Marine Ecosystem

Kerry, Rout George; Pradhan, Pratima; Das, Gitishree; Gouda, Sushanto; Swamy, Mallappa Kumara; Patra, Jayanta Kumar

doi:10.1007/978-981-10-8548-2_13

Cited by 4 publications

(6 citation statements)

References 93 publications

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“…Selain itu, ekstrak alkohol dari A. ilicifolius juga diketahui mempunyai manfaat untuk mencegah penyakit liver (Wei et al, 2015). Ekstrak methanol daun A. ilicifolius terbukti secara signifikan mempunyai manfaat sebagai antiinflammasi melawan luka pada lambung dan hepatitis B pada bebek (Kerry et al, 2018;Wei et al, 2015). Toksikologi dan farmakologi dari benzoxazinoids pada A. ilicifolius telah diketahui dapat membunuh serangga, jamur, bakteri dan virus pada tumbuhan family Gramineae (Kanchanapoom, Salah, et al, 2001).…”

Section: Aktivitas Antioksidan Dan Tpcunclassified

Pemanfaatan ekstrak daun jeruju (<i>Acanthus ilicifolius</i>) sebagai bahan aktif krim anti acne

Nusaibah¹,

Pangestika

Herry

2021

Agrikan: J. Agro. Fish.

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Jeruju (Acanthus ilicifolius) is abundant in mangrove ecosystems in Indonesia and has high antibacterial, antioxidant and anti-inflammatory properties. In addition, the many uses of hazardous chemicals in anti-acne creams are the reason for the need of alternative natural ingredients for making anti-acne creams. So that in this study the use of jeruju leaf extract was added as an active ingredient of anti-acne cream. This research method was carried out by extracting the leaves of jeruju using ethanol solvent then made anti acne cream with extract concentrations of 1%, 5%, 10%, 15%. After that, sensory testing, TPC, antioxidant activity and antibacterial activity against acne-causing bacteria, namely Propionibacterium acne were carried out. The results of the antibacterial activity test of the four concentrations against P.acne produced inhibition zones with a range of values, namely 10.35-12.72 mm.. In testing the antioxidant activity, the best results were obtained at a concentration of 15% extract with an IC50 value of 98.80 ppm. From these results it can be concluded that jeruju is proven to inhibit P.acne bacteria, so that it has the potential to be used as an active ingredient in making anti-acne creams. Suggestions that can be given for further research are to make jeruju extract into a form that is more acceptable to consumers in terms of odor and color without reducing its content.

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Section: Aktivitas Antioksidan Dan Tpcunclassified

Pemanfaatan ekstrak daun jeruju (<i>Acanthus ilicifolius</i>) sebagai bahan aktif krim anti acne

Nusaibah¹,

Pangestika

Herry

2021

Agrikan: J. Agro. Fish.

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“…Similar to other marine organisms, marine plants have been largely unexplored for new antitumoral bioactives in comparison to their terrestrial counterparts. The primary reason for the lack of studies would be due to the inaccessibility [55]. Marine plants are adapted to live in harsh and changing environments and are the source of bioactives with unique and yet-to-know anticancer properties.…”

Section: Mangroves and Other Higher Plantsmentioning

confidence: 99%

“…One of the most highly distinguished plants in terms of producing anticancer chemicals is the mangrove. Mangroves are a highly unexplored group of marine plants found mostly in tropical zones with high salinity and temperature, anaerobic soils, and rapidly changing weather conditions [55]. To be able to adapt to this extreme environment, mangroves produce a wide range of bioactive compounds including hormones, primary and secondary metabolites, and antioxidants.…”

Section: Mangroves and Other Higher Plantsmentioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. Interestingly, a large number of these compounds exert excellent antitumoral properties and have been developed as promising anticancer drugs that have later been approved or are currently under validation in clinical trials. However, due to the high need for these compounds, new methodologies ensuring its sustainable supply are required. Also, optimization of marine bioactives is an important step for their success in the clinical setting. Such optimization involves chemical modifications to improve their half-life in circulation, potency and tumor selectivity. In this review, we outline the most promising marine bioactives that have been investigated in cancer models and/or tested in patients as anticancer agents. Moreover, we describe the current state of development of anticancer marine compounds and discuss their therapeutic limitations as well as different strategies used to overcome these limitations. The search for new marine antitumoral agents together with novel identification and chemical engineering approaches open the door for novel, more specific and efficient therapeutic agents for cancer treatment.

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“…Mangrove ecosystems inhabit the intertidal regions of tropical coastlines and statuaries, typically between 30° north and south of the equator. 1 Recently, mangroves have gain increasing attention due to their remarkable adaptability/tolerance toward hostile environmental conditions (i.e. high salinity, high temperature, muddy anaerobic soils, extreme tides, and strong winds) resulting in novel bioactive products which could be successfully used to treat human diseases, including cancer.…”

Section: Introductionmentioning

confidence: 99%

“…high salinity, high temperature, muddy anaerobic soils, extreme tides, and strong winds) resulting in novel bioactive products which could be successfully used to treat human diseases, including cancer. 1,2 However, research to exploit the potential of mangrove-derived metabolites is still limited.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B

et al. 2020

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Purpose: Naphtho[2,3-b]furan-4,9-dione (Avicequinone B), a natural naphthoquinone isolated from the mangrove tree Avicennia alba, is recognized as a valuable synthetic precursor with anti-proliferative effect. However, the molecular mechanism involved in its bioactivity has not been investigated. This study aimed to determine the selectivity of avicequinone B against cancer cells and the transcriptomic changes induced in colorectal cancer (CRC). Methods: The cytotoxic effect against adenocarcinoma-derived cells or fibroblasts was evaluated using MTT assay. In addition, CRC cells were treated with avicequinone B in different settings to evaluate colony-forming ability, cell cycle progression, apoptosis/necrosis induction, and transcriptome response by RNA-seq. Results: Avicequinone B effectively reduced the viability of breast, colorectal, and lung adenocarcinoma cells with IC50 lower than 10 μM, while fibroblasts were less affected. The induction of G2/M arrest and necrosis-like cell death were observed in avicequinone B-treated HT-29 cells. Furthermore, RNA-seq revealed 490 differentially expressed genes, highlighting the reduction of interferon stimulated genes and proliferative signaling pathways (JAK-STAT, MAPK, and PI3K-AKT), as well as the induction of ferroptosis and miR-21 expression. Conclusion: In short, these results demonstrated the therapeutic potential of avicequinone B and paved the foundation for elucidating its mechanisms in the context of CRC.

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Anticancer Potential of Mangrove Plants: Neglected Plant Species of the Marine Ecosystem

Cited by 4 publications

References 93 publications

Pemanfaatan ekstrak daun jeruju (<i>Acanthus ilicifolius</i>) sebagai bahan aktif krim anti acne

Pemanfaatan ekstrak daun jeruju (<i>Acanthus ilicifolius</i>) sebagai bahan aktif krim anti acne

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B

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