Anticancer Potential of Lichens’ Secondary Metabolites

Solárová, Zuzana; Líšková, Alena; Samec, Marek; Kubatka, Peter; Büsselberg, Dietrich; Solár, Peter

doi:10.3390/biom10010087

Cited by 77 publications

(60 citation statements)

References 117 publications

(141 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the major difference between our study and Ebrahim et al can be considered as the effect of the UA specified study on SK-BR-3. 35 Through the regulation of gene expression, which are related to apoptosis such as Bcl-2 family products anti/pro-apoptotic proteins, p38, and p53, 8,11 lichens play crucial role as apoptosis activators in various cancer cell lines by depending on autonomous cell death. 8,36 Dinçsoy and Cansaran-Duman studied the antiproliferative effect of UA on nonmalignant cell lines (Vero, L929) and cancer cell lines (CaCo2, RD, Hep2C, HepG2, and Wehi).…”

Section: Discussionmentioning

confidence: 99%

“…6 In recent years, lichens and their secondary metabolites have attracted attention as novel candidate molecules for cancer treatment. 7,8 Usnic acid (UA) is the most abundant lichen secondary metabolite, which plays significant roles in different biological activities, mainly antibacterial, antifungal, antiviral, cytotoxic, and antioxidant activity in addition to antiherbivore and insecticidal activity. 7,9 Its chemical property can be described as 2,6-diacetyl-7,9-dihydroxy-8,9bdimethyldibenzofuran-1,3(2H,9bH)-dione.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The expression profiles of apoptosis-related genes induced usnic acid in SK-BR-3 breast cancer cell

Özben

Cansaran-Duman

2020

Hum Exp Toxicol

View full text Add to dashboard Cite

This study aims to determine whether usnic acid (UA) could induce the expression of apoptosis-related genes in apoptosis pathway. The current study has enabled us to better understand the target of UA in the treatment of breast cancer. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Based on the previous study and the results of this study, UA had the most antiproliferative effect on SK-BR-3 breast cancer cell line. We examined differential expression of 88 apoptosis-related genes by quantitative real-time polymerase chain reaction using the apoptosis primary library panel in SK-BR-3 breast cancer cell. We observed a difference in the significant differential expression of 74 apoptosis-related genes in breast cancer after SK-BR-3 cells applied to UA (7.21 µM) for 48 h. The expression level of 56 of these 74 differentiated apoptosis-related genes increased ( p < 0.05), but the expression level of the other 18 related genes decreased ( p < 0.05). In order to evaluate the mechanism of apoptosis of UA, Western blot analysis was performed with Bcl-2, Bax, Caspase-3, and Caspase-9 antibodies. According to the Western blot analysis, we obtained similar results with gene-expression data. These results suggest that UA showed a cytotoxic effect in SK-BR-3 cells through activation of the mitochondrial apoptotic pathway. The obtained results from gene expression revealed that the effect of UA on apoptosis pathway is critical for clinical research.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The expression profiles of apoptosis-related genes induced usnic acid in SK-BR-3 breast cancer cell

Özben

Cansaran-Duman

2020

Hum Exp Toxicol

View full text Add to dashboard Cite

show abstract

“…Flavonoids, for example, suppress cancer through modulation of extracellular matrix (ECM) proteins, inhibition of the epithelial–mesenchymal transition (EMT), and inhibition of cancer cell metabolism [ 13 , 14 ]. Plant phenolic acids and lichens upregulate apoptosis, inhibit proliferation and metastasis, and induce cell cycle arrest, while vanilloids such as capsaicin exert anticancer effects through the modulation of intracellular calcium signaling [ 15 , 16 , 17 ]. Significantly, several natural substances are effective against NB cells in vitro.…”

Section: Natural Substances In the Prevention And Treatment Of Neumentioning

confidence: 99%

Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions

et al. 2020

Self Cite

View full text Add to dashboard Cite

Curcumin, a natural polyphenolic compound derived from the South Asian turmeric plant (Curcuma longa), has well-characterized antioxidant, anti-inflammatory, anti-protein-aggregate, and anticancer properties. Neuroblastoma (NB) is a cancer of the nervous system that arises primarily in pediatric patients. In order to reduce the multiple disadvantages and side effects of conventional oncologic modalities and to potentially overcome cancer drug resistance, natural substances such as curcumin are examined as complementary and supportive therapies against NB. In NB cell lines, curcumin by itself promotes apoptosis and cell cycle arrest through the suppression of serine–threonine kinase Akt and nuclear factor kappa of activated B-cells (NF-κB) signaling, induction of mitochondrial dysfunction, and upregulation of p53 and caspase signaling. While curcumin demonstrates anti-NB efficacy in vitro, cross-validation between NB cell types is currently lacking for many of its specific mechanistic activities. Furthermore, curcumin’s low bioavailability by oral administration, poor absorption, and relative insolubility in water pose challenges to its clinical introduction. Numerous curcumin formulations, including nanoparticles, nanocarriers, and microemulsions, have been developed, with these having some success in the treatment of NB. In the future, standardization and further basic and preclinical trials will be required to ensure the safety of curcumin formulations. While the administration of curcumin is clinically safe even at high doses, clinical trials are necessary to substantiate the practical efficacy of curcumin in the prevention and treatment of NB.

show abstract

“…There are notable reviews on non-vascular epiphytes, bryophyta, regarding their phytochemical and pharmacological activities [2][3][4][5]. There are also extensive reviews on epiphytic lichens covering secondary metabolites and their pharmacological activities [6][7][8][9]. The only available review on vascular epiphytes related to medicinal uses was focused on Orchidaceae [10].…”

Section: Introductionmentioning

confidence: 99%

Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities

et al. 2020

View full text Add to dashboard Cite

This is an extensive review on epiphytic plants that have been used traditionally as medicines. It provides information on 185 epiphytes and their traditional medicinal uses, regions where Indigenous people use the plants, parts of the plants used as medicines and their preparation, and their reported phytochemical properties and pharmacological properties aligned with their traditional uses. These epiphytic medicinal plants are able to produce a range of secondary metabolites, including alkaloids, and a total of 842 phytochemicals have been identified to date. As many as 71 epiphytic medicinal plants were studied for their biological activities, showing promising pharmacological activities, including as anti-inflammatory, antimicrobial, and anticancer agents. There are several species that were not investigated for their activities and are worthy of exploration. These epipythes have the potential to furnish drug lead compounds, especially for treating cancers, and thus warrant indepth investigations.

show abstract

Anticancer Potential of Lichens’ Secondary Metabolites

Cited by 77 publications

References 117 publications

The expression profiles of apoptosis-related genes induced usnic acid in SK-BR-3 breast cancer cell

The expression profiles of apoptosis-related genes induced usnic acid in SK-BR-3 breast cancer cell

Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions

Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities

Contact Info

Product

Resources

About