Anticancer Potential of Flavonoids: Chemistry, Biological Activities, and Future Perspectives

Patil, Vaishali M.; Masand, Neeraj

doi:10.1016/b978-0-444-64179-3.00012-8

Cited by 38 publications

(29 citation statements)

References 167 publications

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“…Natural biomolecules with secondary metabolites have phytomediated content, and display biological activities over a wide range of spectrum, laying the basis for cancer prevention and treatment. Flavonoids are known to inhibit cell growth and act as an anticancer agents [ 28 , 29 ]. Chemoprevention is the use of natural or synthetic substances to inhibit carcinogenesis [ 30 ].…”

Section: Effects Of Flavonoids On Human Healthmentioning

confidence: 99%

Important Flavonoids and Their Role as a Therapeutic Agent

et al. 2020

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Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

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Section: Effects Of Flavonoids On Human Healthmentioning

confidence: 99%

Important Flavonoids and Their Role as a Therapeutic Agent

et al. 2020

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“…To date, it has documented over 8000 different flavonoids and most of them are present in the cells or surfaces of various plant tissue organs [11]. A large variety of edible plant species contains flavonoids, which are considered to be important human dietary constituents [12,13]. Flavonoids are among the most abundant and widespread secondary metabolites groups, which is extremely valuable to mankind, not merely because of their contribution to imparting plant colors, but also due to its several physiologically active members too [14].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

2021

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Background Natural plants and plant-derived formulations have been used by mankind from the ancient period of time. For the past few years, many investigations elaborated the therapeutic potential of various secondary chemicals present in the plants. Literature revealed that the various secondary metabolites, viz. phenolics and flavonoids, are responsible for a variety of therapeutic action in humans. Main body In the present review, an attempt has been made to compile the exploration of natural phenolic compounds with major emphasis on flavonoids and their therapeutic potential too. Interestingly, long-term intake of many dietary foods (rich in phenolics) proved to be protective against the development and management of diabetes, cancer, osteoporosis, cardiovascular diseases and neurodegenerative diseases, etc. Conclusion This review presents an overview of flavonoid compounds to use them as a potential therapeutic alternative in various diseases and disorders. In addition, the present understanding of phenolics and flavonoids will serve as the basis for the next scientific studies.

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“…In vitro studies conclude the potential of flavonoid-induced modulation of kinases with apoptosis, vascularization, cell differentiation, cell proliferation, etc [181]. For example, flavonoids have shown a potential effect in breast cancer as potent inhibitors of aromatase, i.e., cytochrome P450 enzyme complex.…”

Section: Cancermentioning

confidence: 98%

Valorization of Natural Antioxidants for Nutritional and Health Applications

Ferreira-Santos¹,

Genisheva²,

Botelho³

et al. 2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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The significant increase in the world population age, 47 years in 1950 to 73 years in 2020, resulted in an increase in aging related diseases as well as in degenerative diseases. In consequence, researchers have been focusing in the development of new therapies, with a particular emphasis on the use of compounds with antioxidant properties, namely phytochemicals, such as polyphenols and carotenoids. Several in vitro and in vivo studies have demonstrated the phytochemicals antioxidant capacity. Their use is broad, as they can be part of food supplements, medicine and cosmetics. The health benefit of antioxidant phytochemicals is an indisputable question. Phytochemical properties are highly influenced by the natural matrix as well as by extraction process, which have a key role. There are several extraction methods that can be applied depending on the chemical properties of the bioactive compounds. There is a wide range of solvents with different polarities, which allows a selective extraction of the desired target family of compounds. Greener technologies have the advantage to reduce extraction time and solvent quantity in comparison to the most traditional methods. This chapter will focus on the different green extraction strategies related to the recovery of antioxidant bioactive compounds from natural sources, their nutritional and health potential.

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Anticancer Potential of Flavonoids: Chemistry, Biological Activities, and Future Perspectives

Cited by 38 publications

References 167 publications

Important Flavonoids and Their Role as a Therapeutic Agent

Important Flavonoids and Their Role as a Therapeutic Agent

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

Valorization of Natural Antioxidants for Nutritional and Health Applications

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