Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review

Dalil, Davood; Iranzadeh, Saeid; Kohansal, Soroush

doi:10.3389/fphar.2022.979634

Cited by 10 publications

(7 citation statements)

References 67 publications

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“…Cryptotanshinone (CTN) is a diterpenoid monomer and a lipophilic component extracted from the dried roots and rhizomes of the traditional Chinese herb S. miltiorrhiza ( Li et al, 2021 ; Zhang et al, 2023 ). CTN has been proven to possess various biological activities, including antioxidant ( Guo et al, 2022 ), anti-tumor ( Dalil et al, 2022 ), antibacterial ( Zhong et al, 2021 ), and anti-inflammatory effects ( Wu et al, 2020 ). Li ( Popa et al, 2021 ) discovered that CTN effectively suppresses NSCLC cells invasion, proliferation and tumorigenesis.…”

Section: Natural Products Modulating Ferroptosis For Intervention In ...mentioning

confidence: 99%

Induction of ferroptosis by natural products in non-small cell lung cancer: a comprehensive systematic review

Zhang,

Xia,

Wang

et al. 2024

Front. Pharmacol.

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Lung cancer is one of the leading causes of cancer-related deaths worldwide that presents a substantial peril to human health. Non-Small Cell Lung Cancer (NSCLC) is a main subtype of lung cancer with heightened metastasis and invasion ability. The predominant treatment approaches currently comprise surgical interventions, chemotherapy regimens, and radiotherapeutic procedures. However, it poses significant clinical challenges due to its tumor heterogeneity and drug resistance, resulting in diminished patient survival rates. Therefore, the development of novel treatment strategies for NSCLC is necessary. Ferroptosis was characterized by iron-dependent lipid peroxidation and the accumulation of lipid reactive oxygen species (ROS), leading to oxidative damage of cells and eventually cell death. An increasing number of studies have found that exploiting the induction of ferroptosis may be a potential therapeutic approach in NSCLC. Recent investigations have underscored the remarkable potential of natural products in the cancer treatment, owing to their potent activity and high safety profiles. Notably, accumulating evidences have shown that targeting ferroptosis through natural compounds as a novel strategy for combating NSCLC holds considerable promise. Nevertheless, the existing literature on comprehensive reviews elucidating the role of natural products inducing the ferroptosis for NSCLC therapy remains relatively sparse. In order to furnish a valuable reference and support for the identification of natural products inducing ferroptosis in anti-NSCLC therapeutics, this article provided a comprehensive review explaining the mechanisms by which natural products selectively target ferroptosis and modulate the pathogenesis of NSCLC.

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Section: Natural Products Modulating Ferroptosis For Intervention In ...mentioning

confidence: 99%

Induction of ferroptosis by natural products in non-small cell lung cancer: a comprehensive systematic review

Zhang,

Xia,

Wang

et al. 2024

Front. Pharmacol.

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“…233 Cryptotanshinone comes from natural medicines and has the advantages of low toxicity and wide indications. [233][234][235] Yan et al found that cryptotanshinone inhibits tumour growth by promoting ferroptosis in granulocytic myeloid-derived suppressor cells and TNBC cells through proteomics, single-cell transcriptome sequencing, ferroptosis phenotype detection, DARTS, microthermophoresis and molecular docking. 236…”

Section: Cryptotanshinonementioning

confidence: 99%

“…Cryptotanshinone is a monomer with various pharmacological activities extracted from Salvia miltiorrhiza, which has various effects such as anticancer, anti‐inflammatory, anti‐oxidation, anti‐diabetes and anti‐obesity 233 . Cryptotanshinone comes from natural medicines and has the advantages of low toxicity and wide indications 233–235 . Yan et al.…”

Section: Natural Compounds Targeting Ferroptosis In Breast Cancermentioning

confidence: 99%

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Ge,

He,

Zhao

et al. 2023

J Cellular Molecular Medi

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Breast cancer is the most prevalent cancer worldwide and its incidence increases with age, posing a significant threat to women's health globally. Due to the clinical heterogeneity of breast cancer, the majority of patients develop drug resistance and metastasis following treatment. Ferroptosis, a form of programmed cell death dependent on iron, is characterized by the accumulation of lipid peroxides, elevated levels of iron ions and lipid peroxidation. The underlying mechanisms and signalling pathways associated with ferroptosis are intricate and interconnected, involving various proteins and enzymes such as the cystine/glutamate antiporter, glutathione peroxidase 4, ferroptosis inhibitor 1 and dihydroorotate dehydrogenase. Consequently, emerging research suggests that ferroptosis may offer a novel target for breast cancer treatment; however, the mechanisms of ferroptosis in breast cancer urgently require resolution. Additionally, certain natural compounds have been reported to induce ferroptosis, thereby interfering with breast cancer. Therefore, this review not only discusses the molecular mechanisms of multiple signalling pathways that mediate ferroptosis in breast cancer (including metastasis, invasion and proliferation) but also elaborates on the mechanisms by which natural compounds induce ferroptosis in breast cancer. Furthermore, this review summarizes potential compound types that may serve as ferroptosis inducers in future tumour cells, providing lead compounds for the development of ferroptosis‐inducing agents. Last, this review proposes the potential synergy of combining natural compounds with traditional breast cancer drugs in the treatment of breast cancer, thereby suggesting future directions and offering new insights.

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“…[22][23][24] Cryptotanshinone (CTS), a bioactive ingredient extracted from herbal plant Salvia miltiorrhiza Bunge, possesses anti-tumor activity on breast cancer. [25] More attractively, CTS can significantly inhibit STAT3 activation via blocking STAT3 phosphorylation at Tyr705. [26,27] Recent study has also proved the potential of CTS in inhibiting the phosphorylation of STAT3.…”

Section: Introductionmentioning

confidence: 99%

A Dual‐Targeting Liposome Enhances Triple‐Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation

Luo

Yang

Yan

et al. 2023

Small

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Immunotherapy gains increasing focus in treating triple‐negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive tumor microenvironment (ITM). Herein, a LyP‐1 and chondroitin sulfate (CS) dual‐modified liposome co‐loaded with paclitaxel (PTX) and cryptotanshinone (CTS), namely CS/LyP‐1‐PC Lip, is engineered for TNBC chemoimmunotherapy via induction of immunogenic cell death (ICD) and inhibition of signal transducer and activator of transcript‐3 (STAT3) activation. CS/LyP‐1‐PC Lip enhances cellular uptake through p32 and CD44 dual receptor‐mediated endocytosis. Within the tumor, the CS layer is continuously detached by hyaluronidase to release drugs. Subsequently, CTS sensitizes the cytotoxicity of PTX to 4T1 tumor cells. PTX induces ICD of tumor cells and facilitates infiltration of cytotoxic T lymphocyte to provoke immune response. Meanwhile, the concomitant delivery of CTS inhibits STAT3 activation to decrease infiltration of regulatory T cell, M2‐type tumor‐associated macrophage, and myeloid‐derived suppressor cell, thus reversing ITM. Markedly, the dual‐targeting liposome shows superior anti‐tumor efficacy in subcutaneous TNBC mice and significant lung metastasis suppression in tumor metastasis model. Overall, this work offers a feasible combination regimen and a promising nanoplatform for the development of TNBC chemoimmunotherapy.

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Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review

Cited by 10 publications

References 67 publications

Induction of ferroptosis by natural products in non-small cell lung cancer: a comprehensive systematic review

Induction of ferroptosis by natural products in non-small cell lung cancer: a comprehensive systematic review

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

A Dual‐Targeting Liposome Enhances Triple‐Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation

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