Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells

Gothai, Sivapragasam; Muniandy, Katyakyini; Esa, Norhaizan Mohd; Subbiah, Suresh Kumar; Arulselvan, Palanisamy

doi:10.4103/2221-1691.239427

Cited by 13 publications

(6 citation statements)

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“…ex DC. for the management of cancer: Jain and the team had used the methanolic extract of leaves ( Jain et al, 2016 ); Firdhouse and Lalitha had used silver nanoparticles of the aqueous extract ( Firdhouse and Lalitha, 2013 ); Qian and the team had used gold nanoparticles of the aqueous extract of leaves ( Qian et al, 2019 ); D Suganya and the team had used aqueous extract of leaves and stems ( Suganya et al, 2019 ); Pathak and the team had used n-hexane and methanolic extracts of aerial parts ( Pathak et al, 2020 ); Mohaimenul and the team had used ethanolic extract of aerial parts ( Mohaimenul et al, 2020 ); Yap and the team had used ethanolic, 70% ethanolic, 80% methanolic, ethyl acetate, and aqueous extracts of the whole plant ( Yap et al, 2019 ); Sathishkumar and the team had used silver nanoparticles of the aqueous extract of leaves ( Sathishkumar et al, 2016 ); Arulselvan and the team had used ethanolic extract of aerial parts, stem, and leaves ( Arulselvan et al, 2018 ); while Guerra and the team aqueous extract of aerial parts ( Guerra et al, 2003 ). All these studies indicated the true potential of Alternanthera sessilis (L.) R.Br.…”

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

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Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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“…The plates were incubated for 24 h at 37 °C with 95% humidity and 5% CO 2 (Thermo Fischer Scientific, Forma™, Steri-Cycle™, CO 2 incubator, North Shore, New Zealand). Following incubation, an MTT assay was conducted [ 47 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production

et al. 2022

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In the past decades, the regulation of pro-inflammatory cytokine production, including interleukin-8 (IL-8), has been the goal of many targeted therapeutic interventions for Necrotising enterocolitis (NEC), a gastrointestinal disease commonly associated with a very low birth weight in preterm infants. In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated. The TNF-α stimulated HT-29 cells were incubated with undigested or digested Tc-WS-NSPs (CE or ICE), probiotics, and their synbiotic mixtures with Klebsiella oxytoca, an NEC-positive-associated pathogen. Overall, the synbiotic mixtures of digested Tc-WS-NSP-ICE and high bacterial concentrations of L. acidophilus (5.57 × 109), B. breve (2.7 × 108 CFU/mL), and B. infantis (1.53 × 108) demonstrated higher (42.0%, 45.0%, 43.1%, respectively) ability to downregulate IL-8 compared to the sole use of Tc-WS-NSPs (24.5%), or the probiotics L. acidophilus (32.3%), B. breve (37.8%), or B. infantis (33.1%). The ability demonstrated by the Tc-WS-NSPs, the probiotics, and their synbiotics mixtures to downregulate IL-8 production in the presence of an NEC-positive-associated pathogen may be useful in the development of novel prophylactic agents against NEC.

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“…[43] Another study extracted different parts of ASG-the aerial part, leaf, and stem-using ethanol as a solvent and tested them on the human cancerous cell line of colon, HT-29. [44] Anti-cancer properties for each part of plant extract were assessed using MTT assay.…”

Section: Anti-cancer Activitiesmentioning

confidence: 99%

Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar

Ragavan,

Chan,

Goh

et al. 2023

Pharmacogn. Res.

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The weed Alternanthera sessilis, having Green (ASG) and Red (ASR) cultivars, is a member of the Amaranthaceae. Both cultivars are known to possess high medicinal and nutraceutical values as they are widely utilized in traditional medicine. Populations from various Asian regions commonly consume this medicinal weed as part of diet and as therapeutic agent. In general, both cultivars have been employed for treating a broad range of human ailments including cardiovascular diseases, diabetes, hypertension, and inflammatory disorders such as asthma, bronchitis and hepatitis apart from its administration as a painkiller. Following its ethnomedicinal uses, an attempt was made to review and consolidate the phytochemical constituents of ASG and ASR discovered from previous studies that utilized advanced technologies, respective traditional application among different ethnicities of Asia and their established pharmacological properties. All the information in this study was acquired through a literature search of research databases, namely ScienceDirect, Scopus, PubMed and Google Scholar using keywords such as Alternanthera sessilis, Alternanthera sessilis red, dwarf copperleaf and sessile joyweed. The results of each study were reviewed to identify its relevance and the cultivar that was being investigated. All relevant studies were collected and its subsequent results were reported and discussed to provide insights into the health enhancing qualities of ASG and ASR. Inspection of phytoconstituents in ASG and ASR showed the presence of polyphenol, flavonoid, carotenoid, terpenes and alkaloid with polyphenol being the major chemical group found in both cultivars. It was also revealed that whilst ASR is traditionally consumed in China, Malaysia, Singapore, and Taiwan, indigenous usage of ASG is more common in nations such as Sri Lanka, India, and Indonesia. Both ASG and ASR showed potent anti-oxidant, anti-hyperglycemic, antimicrobial, antifungal and hepatoprotective effects while the anti-inflammatory, anti-cancer and analgesic properties were disclosed in ASG only. Further processing and commercialization of this remedial weed as a product benefiting the wellbeing of humans is recommended as Alternanthera sessilis has high potential to be utilized as a curative agent while being a vital ingredient that can be included in daily consumption.

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Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells

Cited by 13 publications

References 1 publication

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production

Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar

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