Anticancer Potencies of Pt^II‐ and Pd^II‐linked M₂L₄ Coordination Capsules with Improved Selectivity

Abstract

Pt(II) - and Pd(II)-linked M2 L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL-60 and SKW-3) and pronounced toxicity against cisplatin-resistant cells (HL-60/CDDP). Notably, the cytotoxic selectivities of the Pt(II) and Pd(II) capsules toward cancerous cells are up to 5.3-fold higher than that of cisplatin, as estimated through the non-malignant/malignant-cells toxicity ratio employing normal kidney cells (HEK-293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules.

Anticancer Activity and Cisplatin Binding Ability of Bis-Quinoline and Bis-Isoquinoline Derived [Pd2L4]4+ Metallosupramolecular Cages

“…Additionally, they have measured the cytotoxicity of mixtures of the cages and cisplatin and unsurprisingly have found that those mixtures are more cytotoxic than cage alone (IC 50 = 2–13 μM). Yoshizawa, Ahmedova and co-workers have also found that [M 2 ( L ) 4 ] 4+ (M = Pd 2+ or Pt 2+ ) cages with similar, but more hydrophobic, dipyridyl anthracenyl ligands ( L anthracene ) display high anticancer activity (IC 50 values range from 0.9 to 37.4 μM against HL-60, HL-60/Dox, HT-29, T-24, SKW-3 cancer cell lines) (Ahmedova et al, 2016 ; Anife et al, 2016 ).…”

A luminescent [Pd4Ru8]24+ supramolecular cage

“…2 For instance, cages have been explored in the context of "artificial enzyme" catalysis, 3 for hazardous chemical capture, 4 reactive intermediate stabilisation, 2c for drug delivery and release, 5 as well as in molecular sensing 6 and in biology. 7 More recently, desirable photophysical properties such as emission tuning, 8 encapsulation-assisted energy and electron transfer, 9 longlived charge-separated state lifetimes 10 and photoresponsive guest uptake/release 11 have been achieved by integrating emissive moieties such as metalloporphyrins, metal complexes or fluorescent ligands, into the backbone of metallosupramolecular macrocycles and cages. 6a, 12 Ruthenium(II) polypyridyl complexes can generally access multiple oxidation states, and they enjoy a rich history in photocatalysis.…”

Subcellular Duplex DNA and G‐Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

“…[1][2][3] Despite the extraordinary growth of the chemistry of SCCs,s tudies reporting on their potential biomedical applications are so far extremely limited. [7][8][9][10] Pt-ensembles can in principle be designed to mimic complex cellular regulatory motifs.Therefore,they can act through unusual modes of action potentially capable to overcome the drawbacks (for example resistance) of clinically applied Pt II drugs. [2,[4][5][6] We and others focused our efforts on the intrinsic anticancer potential of SCCs, [5] devoting particular attention to those supramolecules where platinum drives the self-assembly.…”